Multimodal hard X-ray imaging of a mammography phantom at a compact synchrotron light source

Schleede, Simone; Bech, Martin; Achterhold, Klaus; Potdevin, Guillaume; Gifford, Martin; Loewen, R.J.; Limborg, C.; Ruth, Ronald D.; Pfeiffer, Franz

doi:10.1107/s0909049512017682

Cited by 32 publications

(16 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tight focusing of both the electron bunch and the infrared laser results in high flux and a small source size of 40 × 40 μm 2 rms. The high degree of spatial coherence can be exploited in the straightforward use of refraction-based imaging techniques (46,47), and the intrinsic energy bandwidth of ΔE/E peak = 3% allows for monochromatic biomedical imaging experiments. The angular divergence of about 4 mrad is larger than at conventional synchrotron sources and provides a circular field of view of about 6 cm at a distance of 16 m from the source, which can be used to measure relatively large biological samples.…”

Section: Methodsmentioning

confidence: 99%

Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

Schleede

Meinel²,

Bech

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

174

128

View full text Add to dashboard Cite

In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.

show abstract

Section: Methodsmentioning

confidence: 99%

Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

Schleede

Meinel²,

Bech

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

174

128

View full text Add to dashboard Cite

show abstract

“…High flux and a small source size (50 × 50 μm 2 ) are achieved by tight focusing of electron bunch and laser pulse. A high degree of spatial coherence and the intrinsic energy bandwidth of ΔE=E peak = 3 % make a CLS well-suited for monochromatic refraction-based imaging (15)(16)(17)(18). The angular divergence of 4 mrad yields a circular field of view of ∼6 cm at a distance of 16 m from the source, allowing for measurement of relatively large biological samples.…”

Section: Clsmentioning

confidence: 99%

“…First studies using a grating interferometer at a CLS yielded promising results for phase-contrast and dark-field projection images (15)(16)(17)(18). Quantitative attenuation-based CT demonstrated the capability of the CLS to overcome beam hardening issues and to provide precise density values (19).…”

mentioning

confidence: 99%

X-ray phase-contrast tomography with a compact laser-driven synchrotron source

Eggl

Schleede

Bech

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

Between X-ray tubes and large-scale synchrotron sources, a large gap in performance exists with respect to the monochromaticity and brilliance of the X-ray beam. However, due to their size and cost, large-scale synchrotrons are not available for more routine applications in small and medium-sized academic or industrial laboratories. This gap could be closed by laser-driven compact synchrotron light sources (CLS), which use an infrared (IR) laser cavity in combination with a small electron storage ring. Hard X-rays are produced through the process of inverse Compton scattering upon the intersection of the electron bunch with the focused laser beam. The produced X-ray beam is intrinsically monochromatic and highly collimated. This makes a CLS well-suited for applications of more advanced--and more challenging--X-ray imaging approaches, such as X-ray multimodal tomography. Here we present, to our knowledge, the first results of a first successful demonstration experiment in which a monochromatic X-ray beam from a CLS was used for multimodal, i.e., phase-, dark-field, and attenuation-contrast, X-ray tomography. We show results from a fluid phantom with different liquids and a biomedical application example in the form of a multimodal CT scan of a small animal (mouse, ex vivo). The results highlight particularly that quantitative multimodal CT has become feasible with laser-driven CLS, and that the results outperform more conventional approaches.phase-contrast tomography | dark-field tomography | grating interferometer | inverse Compton X-rays | X-ray imaging W ith the introduction of the grating interferometer (1-3), the field of X-ray phase-contrast imaging has seen great advances in the past decade. In comparison with conventional attenuation-contrast imaging, the phase-contrast modality greatly improves soft-tissue contrast, which can, for example, be used for better tumor visualization (4). With the development of the TalbotLau interferometer, grating-based phase-contrast imaging has become feasible not only with synchrotron sources, but also with standard X-ray tube sources (3, 5). On the downside, the visibility is degraded due to the broad polychromatic spectrum of the X-ray tube sources, thus compromising the image quality. Brilliant and highly monochromatic synchrotron sources yield superior results for high-resolution and high-sensitivity measurements (2, 4, 6-13).However, limited availability, high cost, and small fields of view make synchrotron sources incompatible with clinical applications or preclinical research on, e.g., small-animal disease models in close vicinity to biomedical laboratories with small-animal infrastructure. Offering a monochromatic beam as well as higher brilliance and coherence than X-ray tube sources, compact synchrotron sources can be classified between tube sources and synchrotron sources. These features are achieved with a compact light source (CLS), which has a size that is compatible with conventional laboratories, making it an interesting candidate for preclinical and mater...

show abstract

“…The latter results in a reduced contrast-to-noise ratio (CNR) in the differential phase-contrast (DPC) images [7]. This difficulty is not present in grating based phase-contrast imaging setups with monoenergetic X-ray sources, like monochromatized synchrotron beams or like the Compton backscattering X-ray source which has been used by Bech et al [8] and Schleede et al [9,10]. However the complexity of such a setup hinders a broad range use in medical imaging.…”

Section: Introductionmentioning

confidence: 99%

Grating-based x-ray phase-contrast imaging with a multi energy-channel photon-counting pixel detector

Pelzer¹,

Weber²,

Anton³

et al. 2013

Opt. Express

View full text Add to dashboard Cite

Abstract:We have carried out grating-based x-ray differential phasecontrast measurements with a hybrid pixel detector in 16 energy channels simultaneously. A method for combining the energy resolved phase-contrast images based on energy weighting is presented. An improvement in contrast-to-noise ratio by 58.2% with respect to an emulated integrating detector could be observed in the final image. The same image quality could thus be achieved with this detector and with energy weighting at 60.0% reduced dose compared to an integrating detector. The benefit of the method depends on the object, spectrum, interferometer design and the detector efficiency.

show abstract

Multimodal hard X-ray imaging of a mammography phantom at a compact synchrotron light source

Cited by 32 publications

References 22 publications

Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

X-ray phase-contrast tomography with a compact laser-driven synchrotron source

Grating-based x-ray phase-contrast imaging with a multi energy-channel photon-counting pixel detector

Contact Info

Product

Resources

About