Multimodal exercise training during myeloablative chemotherapy: a prospective randomized pilot trial

Oechsle, Karin; Aslan, Zeynep; Suesse, Yvonne; Jensen, Wiebke; Bokemeyer, Carsten; Wit, Maike de

doi:10.1007/s00520-013-1927-z

Cited by 60 publications

(97 citation statements)

References 35 publications

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“…Of the sixteen studies involving patients in active treatment [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] , six demonstrated that, compared with the control group, the intervention group experienced significant improvements in qol 30,31,33,[38][39][40]43 . In the thirteen post-treatment intervention studies 10,12,14,[45][46][47][48][49][50][51][52][53][54] , two reported similar significant differences between groups 46,49 .…”

Section: Quality Of Lifementioning

confidence: 99%

Exercise for People with Cancer: A Clinical Practice Guideline

et al. 2017

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Background Development of this guideline was undertaken by the Exercise for People with Cancer Guideline Development Group, a group organized by Cancer Care Ontario’s Program in Evidence-Based Care (pebc). The purpose of the guideline was to provide guidance for clinicians with respect to exercise for patients living with cancer, focusing on the benefits of specific types of exercise, recommendations about screening requirements for new referrals, and safety concerns.Methods Consistent with the pebc’s standardized approach, a systematic search was conducted for existing guidelines, and systematic literature searches were performed in medline and embase for both systematic reviews and primary literature. Content and methodology experts performed an internal review, which was followed by an external review by targeted experts and intended users.Results The search identified three guidelines, eighteen systematic reviews, and twenty-nine randomized controlled trials with relevance to the topic. The present guideline provides recommendations for the duration, frequency, and intensity of exercise appropriate for people living with cancer. It also provides recommendations for pre-exercise assessment, safety concerns, and delivery models.Conclusions There is sufficient evidence to show that exercise provides benefits in quality of life and muscular and aerobic fitness for people with cancer both during and after treatment, and that it does not cause harm. The present guideline is intended to support the Canadian Society for Exercise Physiology’s Canadian physical activity guidelines. The recommendations are intended for clinicians and institutions treating cancer patients in Ontario, and for policymakers and program planners involved in the delivery of exercise programs for cancer patients.

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Section: Quality Of Lifementioning

confidence: 99%

Exercise for People with Cancer: A Clinical Practice Guideline

et al. 2017

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“…Second, the study helps to define that the first 8 weeks of chemotherapy are the period of greatest need for interventions by the multidisciplinary team, since some studies have already demonstrated the health benefits of psychological interventions and physical exercise programs in cancer patients. 6,7,13,14,24 Backman et al 25 conducted an interesting interventional study in breast cancer patients in 2014. Patients were advised to take a daily walk for 10 weeks during chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…5 Other authors have described how the low level of physical fitness and the reduced functional capacity of cancer patients to perform activities of daily living usually negatively impact the life of the survivors. 6,7 In the medium and long term, the psychosocial and physical problems faced by cancer patients can negatively affect their quality of life. 8 This is more and more concerning given that there is empirical evidence that a reduced quality of life correlates to a shorter survival after cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

What clinical, functional, and psychological factors before treatment are predictors of poor quality of life in cancer patients at the end of chemotherapy?

Mangia

Coqueiro

Azevedo³

et al. 2017

Rev. Assoc. Med. Bras.

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Objective: To correlate physical activity level (PAL), functional capacity and psychological state with quality of life (QoL) in cancer patients undergoing chemotherapy (CT). Method: Observational cohort study. Patients (n=121) with any primary cancer site with indications of chemotherapy with palliative or curative intent were evaluated at three moments: 1) patient admission (week 0), before chemotherapy; 2) week 8; 3) end of CT. Data were collected regarding QoL, PAL, clinical data, functional capacity (short walking distance test, sitting-rising test, isometric manual gripping force), and anxiety and depression tests. Results: There was significant improvement at the end of CT for: level of physical activity; walk test (> 500 meters); sitting-rising test (> 20x). There was a significant reduction in the prevalence of moderate/severe depression. The prevalence of high QoL showed a significant increase in evaluation 3 (42.4% vs. 40.0% vs. 59.2%, p=0.02). Education up to high school level, low PAL, walking < 300 meters, sitting and rising < 20 times, having depression (moderate to severe) and QoL that was not high at the start of treatment (week 0) all proved to be risk factors for low quality of life at week 16. Conversely, early staging, curative intent chemotherapy and low-grade symptoms were shown to be protective factors. Conclusion: Performing less than 20 movements in the sitting-rising test and low PAL at the start of chemotherapy represent independent risk factors for low quality of life at the end of chemotherapy.

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“…Fourteen systematic reviews [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] found an improvement in qol for people with cancer participating in an exercise intervention during the active treatment or post-treatment periods (Table v). Of the sixteen rcts involving patients in active treatment [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] , seven reported significant differences between the intervention and control groups (Table vi) 23,24,26,[31][32][33]36 . In the thirteen posttreatment intervention studies [38][39][40][41][42][43][44]…”

Section: Qol and Muscular And Aerobic Fitnessmentioning

confidence: 99%

“…One systematic review 20 found that cardiopulmonary exercise testing was a safe, noninvasive method to measure cardiopulmonary fitness in people living with cancer, both during and after treatment. Seventeen rcts [22][23][24]27,29,[30][31][32][33]37,39,42,45,47,[51][52][53] found that no adverse events or side effects were attributable to the exercise program. Seven 26,28,34,35,40,46,50 did not report on adverse events at all.…”

Section: Commentsmentioning

confidence: 99%

Exercise for people with cancer: a systematic review

et al. 2017

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Background This systematic review was completed by the Exercise for People with Cancer Guideline Development Group, a group organized by Cancer Care Ontario’s Program in Evidence-Based Care (pebc). It provides background and guidance for clinicians with respect to exercise for people living with cancer in active and post treatment. It focuses on the benefits of specific types of exercise, pre-screening requirements for new referrals, safety concerns, and delivery models.Methods Using the pebc’s standardized approach, medline and embase were systematically searched for existing guidelines, systematic reviews, and primary literature.Results The search identified two guidelines, eighteen systematic reviews, and twenty-nine randomized controlled trials with relevance to the topic. The present review provides conclusions about the duration, frequency, and intensity of exercise appropriate for people living with cancer.Conclusions The evidence shows that exercise is safe and provides benefit in quality of life and in muscular and aerobic fitness for people with cancer both during and after treatment. The evidence is sufficient to support the promotion of exercise for adults with cancer, and some evidence supports the promotion of exercise in group or supervised settings and for a long period of time to improve quality of life and muscular and aerobic fitness. Exercise at moderate intensities could also be sustainable for longer periods and could encourage exercise to be continued over an individual’s lifetime. It is important that a pre-screening assessment be conducted to evaluate the effects of disease, treatments, and comorbidities.

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Multimodal exercise training during myeloablative chemotherapy: a prospective randomized pilot trial

Cited by 60 publications

References 35 publications

Exercise for People with Cancer: A Clinical Practice Guideline

Exercise for People with Cancer: A Clinical Practice Guideline

What clinical, functional, and psychological factors before treatment are predictors of poor quality of life in cancer patients at the end of chemotherapy?

Exercise for people with cancer: a systematic review

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