Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer

Semkina, Alevtina S.; Abakumov, Maxim A.; Skorikov, Alexander; Abakumova, Tatiana O.; Melnikov, Pavel; Grinenko, N. F.; Cherepanov, S. A.; Vishnevskiy, Daniil A.; Naumenko, Victor; Ionova, K. P.; Majouga, Alexander G.; Chekhonin, V. P.

doi:10.1016/j.nano.2018.04.019

Cited by 61 publications

(25 citation statements)

References 37 publications

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“…With the improvement in science and medicine, targeted therapies that increase the efficacy and precision of the treatment and decrease the toxicity are now an ambitious solution under development [89]. Several studies have reported the use of nanoparticles as a strategy to combat breast cancer, such as a new VEGF-targeted nanocarrier, composed of magnetic nanoparticles coated with albumin that carry doxorubicin and in which it conjugates monoclonal antibodies to VEGF, which increases their specificity for the tumor [90]. Additionally, due to its magnetic core, this system can still be used for diagnosis, and its detection is possible by MRI after i.v.…”

Section: Nanotheranostics In Diagnosis and Treatment Of Cancermentioning

confidence: 99%

“…injection. The nanoparticles were synthesized by thermal decomposition of iron (III) acetylacetonate in benzyl alcohol, coated with BSA (bovine serum albumin) and PEG and conjugated with anti-VEGF monoclonal antibodies [90]. In this study, researchers optimized the nanoparticle size to less than 50 nm, as well as the compounds present in the coating, since these are two important factors for the nanoparticles to remain longer in the bloodstream.…”

Section: Nanotheranostics In Diagnosis and Treatment Of Cancermentioning

confidence: 99%

“…In this study, researchers optimized the nanoparticle size to less than 50 nm, as well as the compounds present in the coating, since these are two important factors for the nanoparticles to remain longer in the bloodstream. Regarding the coating, nanoparticles were pegylated to guarantee an efficient loading process with doxorubicin, to prevent interaction with the plasma proteins and to avoid their absorption by RES, and managed to obtain superior results compared to clinically approved formulations [90].…”

Section: Nanotheranostics In Diagnosis and Treatment Of Cancermentioning

confidence: 99%

See 2 more Smart Citations

Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

et al. 2019

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Theranostics has emerged in recent years to provide an efficient and safer alternative in cancer management. This review presents an updated description of nanotheranostic formulations under development for skin cancer (including melanoma), head and neck, thyroid, breast, gynecologic, prostate, and colon cancers, brain-related cancer, and hepatocellular carcinoma. With this focus, we appraised the clinical advantages and drawbacks of metallic, polymeric, and lipid-based nanosystems, such as low invasiveness, low toxicity to the surrounding healthy tissues, high precision, deeper tissue penetration, and dosage adjustment in a real-time setting. Particularly recognizing the increased complexity and multimodality in this area, multifunctional hybrid nanoparticles, comprising different nanomaterials and functionalized with targeting moieties and/or anticancer drugs, present the best characteristics for theranostics. Several examples, focusing on their design, composition, imaging and treatment modalities, and in vitro and in vivo characterization, are detailed herein. Briefly, all studies followed a common trend in the design of these theranostics modalities, such as the use of materials and/or drugs that share both inherent imaging (e.g., contrast agents) and therapeutic properties (e.g., heating or production reactive oxygen species). This rationale allows one to apparently overcome the heterogeneity, complexity, and harsh conditions of tumor microenvironments, leading to the development of successful targeted therapies.

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Section: Nanotheranostics In Diagnosis and Treatment Of Cancermentioning

confidence: 99%

Section: Nanotheranostics In Diagnosis and Treatment Of Cancermentioning

confidence: 99%

Section: Nanotheranostics In Diagnosis and Treatment Of Cancermentioning

confidence: 99%

See 1 more Smart Citation

Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

et al. 2019

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show abstract

“…For instance, antibody drug conjugates are being utilized in both preclinical studies as well as early and late stage clinical trials. These studies have shown increased ability to target diseased cells, and increased antitumor potency [140][141][142][143]. Peptide and aptamer based delivery systems have also shown efficacy in reducing offtarget effects and increasing drug delivery to the tumor [144][145][146].…”

Section: Improving Active Targetingmentioning

confidence: 99%

Fluorescence Guidance in Surgical Oncology: Challenges, Opportunities, and Translation

Olson

Mohs

2018

Mol Imaging Biol

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Surgical resection continues to function as the primary treatment option for most solid tumors. However, the detection of cancerous tissue remains predominantly subjective and reliant on the expertise of the surgeon. Surgery that is guided by fluorescence imaging has shown clinical relevance as a new approach to detecting the primary tumor, tumor margins, and metastatic lymph nodes. It is a technique to reduce recurrence and increase the possibility of a curative resection. While significant progress has been made in developing this emerging technology as a tool to assist the surgeon, further improvements are still necessary. Refining imaging agents and tumor targeting strategies to be a precise and reliable surgical strategy is essential in order to translate this technology into patient care settings. This review seeks to provide a comprehensive update on the most recent progress of fluorescence-guided surgery and its translation into the clinic. By highlighting the current status and recent developments of fluorescence image-guided surgery in the field of surgical oncology, we aim to offer insight into the challenges and opportunities that require further investigation.

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“…VEGF-targeted nanoparticles which are loaded with anticancer agent doxorubicin display 50% enhance in the 4T1 tumour-bearing mice survival rate. MRI diagnosed nanoparticles accumulation in the tumour 24 h after injection [15]. Studies on magnetic nanoparticles should be continued in view of the significant role of these nanoparticles in the field of drug delivery systems.…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Current aspects in treatment of breast cancer based of nanodrug delivery systems and future prospects

Allahverdiyev

Parlar

Dinparvar

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Breast cancer is one of the most common diseases worldwide. The risk of getting this disease in female is 30% and the mortality rate is 14%. The breast cancer treatment is based on surgery, chemotherapy and radiotherapy. However, an effective treatment method has not been developed. The main cause of failure in the treatment is cancer stem cells metastasis and chemo-resistance. The use of nanocarrier systems against breast cancer stem cells has great importance. Not only advantages of polymeric drug delivery systems are increasing the stability and reduce the side effects of drugs, but also they have disadvantages such as biocompatibility and long-term potential safety. However, in recent years, studies on exosomes provide several advantages. Exosomes usage as nanocarrier do not cause immunological reactions also the drug effectively transport into the cytosol of targeted cell and have more stability characteristics. Although there are studies about various nanocarrier systems in literature against breast cancer but in general, we have not found any review that brings them together and develops a systematic approach to solving the problem. This review mentions prospective new strategies based on various nanocarrier systems and emphasize the importance of exosome based on drug delivery systems in the treatment of breast cancer.

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Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer

Cited by 61 publications

References 37 publications

Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

Fluorescence Guidance in Surgical Oncology: Challenges, Opportunities, and Translation

Current aspects in treatment of breast cancer based of nanodrug delivery systems and future prospects

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