Multimodal connectivity of motor learning-related dorsal premotor cortex

Hardwick, Robert M.; Lesage, Elise; Eickhoff, Claudia R.; Clos, Mareike; Fox, Peter T.; Eickhoff, Simon B.

doi:10.1016/j.neuroimage.2015.08.024

Cited by 38 publications

(31 citation statements)

References 110 publications

(162 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Like the results reported by Hardwick et al [], in this study, most areas found to be activated according to the MACM were also activated in the rsFC study. We reported the peak coordinates of the areas identified in both the rsFC and MACM analyses in Supporting Information Table S3.…”

Section: Resultssupporting

confidence: 89%

Multimodal connectivity‐based parcellation reveals a shell‐core dichotomy of the human nucleus accumbens

Xia

Fan

Chen

et al. 2017

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

The subdifferentiation of the nucleus accumbens (NAc) has been extensively studied using neuroanatomy and histochemistry, yielding a well-accepted dichotomic shell/core architecture that reflects dissociable roles, such as in reward and aversion, respectively. However, in vivo parcellation of these structures in humans has been rare, potentially impairing future research into the structural and functional characteristics and alterations of putative NAc subregions. Here, we used three complementary parcellation schemes based on tractography, task-independent functional connectivity, and task-dependent co-activation to investigate the regional differentiation within the NAc. We found that a 2-cluster solution with shell-like and core-like subdivisions provided the best description of the data and was consistent with the earlier anatomical shell/core architecture. The consensus clusters from this optimal solution, which was based on the three schemes, were used as the final parcels for the subsequent connection analyses. The resulting connectivity patterns presented inter-hemispheric symmetry, convergence and divergence across the modalities, and, most importantly, clearly distinct patterns between the two subregions. This convergent connectivity patterns also confirmed the connections in animal models, supporting views that the two subregions could have antagonistic roles in some circumstances. Finally, the identified parcels should be helpful in further neuroimaging studies of the NAc.

show abstract

Section: Resultssupporting

confidence: 89%

Multimodal connectivity‐based parcellation reveals a shell‐core dichotomy of the human nucleus accumbens

Xia

Fan

Chen

et al. 2017

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

show abstract

“…We therefore argue that the increased PMd recruitment was beneficial, affording a more precise synchronization of the finger tapping with the regular pace provided by the visual cue. Our findings are in good agreement with previous work showing that the PMd plays a prominent role in visuomotor integration (58)(59)(60)(61)(62)(63).…”

Section: Discussionsupporting

confidence: 93%

Multimodal finger-printing of the human precentral cortex forming the motor hand knob

Dubbioso

Madsen

Thielscher

et al. 2020

Preprint

View full text Add to dashboard Cite

Transcranial magnetic stimulation (TMS) of the precentral hand knob can evoke motor evoked potentials (MEP) in contralateral hand muscles. Biophysical modelling points to the dorsal premotor cortex (PMd) in the superficial crown-lip region as primary site of TMS-induced neuronal excitation. Here, we used a sulcusaligned MRI-informed TMS mapping approach to determine the optimal site (hotspot) for evoking MEPs in the precentral hand knob. Individual precentral hotspot location varied along the rostro-caudal axis. Individuals with a more rostral location had longer MEP latencies. Spatiotemporal "hotspot rostrality" was associated with higher precentral myelin-related signals, stronger movement-related activation of PMd in the precentral crown, and higher temporal precision during paced finger tapping. Together, our multimodal mapping approach provides first-time evidence for behaviourally relevant, structural and functional phenotypic variation in the crown of human precentral motor hand knob. The results have important implications for physiological and interventional TMS studies targeting the precentral hand knob.

show abstract

“…The highest convergence will probably be found in the seed region, but significant convergence outside the seed indicates significant co-activation. Meta-Analytic Co-Activation Modeling (MACM) thus provides a complementary aspect of long-range integration relative to measures such as resting-state functional connectivity or structural covariance (Clos et al, 2014; Hardwick et al, 2015). …”

Section: Discussionmentioning

confidence: 99%

Behavior, sensitivity, and power of activation likelihood estimation characterized by massive empirical simulation

et al. 2016

Self Cite

View full text Add to dashboard Cite

Given the increasing number of neuroimaging publications, the automated knowledge extraction on brain-behavior associations by quantitative meta-analyses has become a highly important and rapidly growing field of research. Among several methods to perform coordinate-based neuroimaging meta-analyses, Activation Likelihood Estimation (ALE) has been widely adopted. In this paper, we addressed two pressing questions related to ALE meta-analysis: i) Which thresholding method is most appropriate to perform statistical inference? ii) Which sample size, i.e., number of experiments, is needed to perform robust meta-analyses? We provided quantitative answers to these questions by simulating more than 120,000 meta-analysis datasets using empirical parameters (i.e., number of subjects, number of reported foci, distribution of activation foci) derived from the BrainMap database. This allowed to characterize the behavior of ALE analyses, to derive first power estimates for neuroimaging meta-analyses, and to thus formulate recommendations for future ALE studies. We could show as a first consequence that cluster-level family-wise error (FWE) correction represents the most appropriate method for statistical inference, while voxel-level FWE correction is valid but more conservative. In contrast, uncorrected inference and false-discovery rate correction should be avoided. As a second consequence, researchers should aim to include at least 20 experiments into an ALE meta-analysis to achieve sufficient power for moderate effects. We would like to note, though, that these calculations and recommendations are specific to ALE and may not be extrapolated to other approaches for (neuroimaging) meta-analysis.

show abstract

Multimodal connectivity of motor learning-related dorsal premotor cortex

Cited by 38 publications

References 110 publications

Multimodal connectivity‐based parcellation reveals a shell‐core dichotomy of the human nucleus accumbens

Multimodal connectivity‐based parcellation reveals a shell‐core dichotomy of the human nucleus accumbens

Multimodal finger-printing of the human precentral cortex forming the motor hand knob

Behavior, sensitivity, and power of activation likelihood estimation characterized by massive empirical simulation

Contact Info

Product

Resources

About