Multimodal approach and long-term survival in a patient with recurrent metastatic acinar cell carcinoma of the pancreas: A case report

Jauch, Sarah F.; Morris, Van K.; Jensen, Corey T.; Kaseb, Ahmed O.

doi:10.1016/j.pan.2015.09.006

Cited by 13 publications

(11 citation statements)

References 25 publications

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“…The literature over the last several decades has described panniculitis presenting in the setting of pancreatic ACC [ 2 , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] ]. Most of these case reports demonstrate the poor prognosis associated with the condition, though some reveal improvement of the panniculitis when treating the underlying pathology [ 10 , 14 ]. Few case reports have demonstrated successful surgical resection of the primary and metastatic lesions to treat pancreatic ACC [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Most of these case reports demonstrate the poor prognosis associated with the condition, though some reveal improvement of the panniculitis when treating the underlying pathology [ 10 , 14 ]. Few case reports have demonstrated successful surgical resection of the primary and metastatic lesions to treat pancreatic ACC [ 14 , 15 ]. Good outcomes can be achieved with multimodal therapy when treating panniculitis in both locoregional and metastatic ACC [ 2 , 10 , 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Few case reports have demonstrated successful surgical resection of the primary and metastatic lesions to treat pancreatic ACC [ 14 , 15 ]. Good outcomes can be achieved with multimodal therapy when treating panniculitis in both locoregional and metastatic ACC [ 2 , 10 , 14 , 15 ]. A survival benefit has been demonstrated with surgery in both locally advanced and metastatic ACC [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

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The surgical management of metastatic pancreatic acinar cell carcinoma and associated pancreatic panniculitis—A case report and literature review

Clarke

Stevens

Bennett

et al. 2020

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The surgical management of metastatic pancreatic acinar cell carcinoma and associated pancreatic panniculitis—A case report and literature review

Clarke

Stevens

Bennett

et al. 2020

International Journal of Surgery Case Reports

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“…Most married patients were men and received chemotherapy. Past studies have shown that chemotherapy can benefit patients [6,25,26], and men might be more tolerant of higher intensity than women. Therefore, we believe that married patients have a better prognosis than unmarried patients, and our contradictory conclusions could have been caused by a small sample size.…”

Section: Married Patients Had a Better Prognosismentioning

confidence: 99%

The contemporary trend in worsening prognosis of pancreatic acinar cell carcinoma: A population-based study

et al. 2020

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Background Primary acinar cell carcinoma (ACC) is a rare exocrine tumor of the pancreas with unclear clinical characteristics. Our goal was to determine the incidence and update the clinical characteristics and outcomes of ACC. Methods Through the Surveillance, Epidemiology, and End Results (SEER) database, we identified 252 patients with the latest diagnosis of ACC (2004–2016). The age-adjusted incidence (AAI) was calculated using the SEER*Stat Software version 8.3.6. The Kaplan–Meier method was used to draw survival curves and differences among them were compared by the log-rank test. Cox proportional hazards models were used to evaluate factors that had independent predictive effects on the overall survival. Results The AAI of pancreatic ACC was on the rise with the mean age at diagnosis of 63.79±14.79 years. Most patients (15.9%) had poorer differentiated tumors. The patients presented with distant stage were 54.4% compared with 53.1% between 1988 and 2003. The 1-, 2-, and 5-years survival rates for pancreatic ACC patients were 53.5%, 34.6%,17.5%, respectively (compared with 78.5%, 67.0%, and 42.8%, between 1988 and 2003). The multivariate COX analysis showed that the patient's age, surgery, chemotherapy, and summary stage, but not marital status were independent prognosis factors for ACC. Conclusions Pancreatic ACC is a highly malignant tumor with an increasing incidence in recent years. The rate of distant metastasis is increasing and the survival rate is worse than in the past, suggesting that it may require more aggressive treatment and follow-up. Surgery, radiotherapy, and chemotherapy are all effective treatments, but prospective studies are still needed to verify them.

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“…Accounting for only 1% of all pancreatic tumors, pancreatic acinar cell carcinoma (ACC), which originates from acinar elements of the exocrine pancreas, is a rare neoplasm [ 1 , 2 ]. Pancreatic ACC has been better understood since the first report by Berner in 1908 [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Pancreatic acinar cell carcinoma—case report and literature review

Zhang

2018

BMC Cancer

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BackgroundPancreatic acinar cell carcinoma (ACC) is a rare tumor that constitutes 1% of all pancreatic neoplasms. Pancreatic ACC has unique characteristics in terms of biological behavior, imaging and prognosis.Case presentationThe present study reported two cases of pancreatic ACC confirmed by postoperative pathology and both cases exhibited several different imaging features and laboratory test results. Both cases had approximately 4 cm mass located in uncinate process of pancreas. Dilated intra- and extra-hepatic bile ducts was observed in one case, along with calcification. Heterogeneous enhancement of the tumor was exhibited in both patients with different intensities. Obstructive jaundice, elevated α-fetoprotein and CA 19–9 was found in one case, while the other case had normal liver function and tumor markers.ConclusionsIt was difficult to accurately diagnose pancreatic ACC before the operation despite its unique characteristics. Radical resection was the best treatment modality for resectable pancreatic ACC.

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Multimodal approach and long-term survival in a patient with recurrent metastatic acinar cell carcinoma of the pancreas: A case report

Cited by 13 publications

References 25 publications

The surgical management of metastatic pancreatic acinar cell carcinoma and associated pancreatic panniculitis—A case report and literature review

The surgical management of metastatic pancreatic acinar cell carcinoma and associated pancreatic panniculitis—A case report and literature review

The contemporary trend in worsening prognosis of pancreatic acinar cell carcinoma: A population-based study

Pancreatic acinar cell carcinoma—case report and literature review

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