Multimodal Applications of Transcranial Magnetic Stimulation for Circuit-Based Psychiatry

Camprodon, Joan A.; Pascual‐Leone, Álvaro

doi:10.1001/jamapsychiatry.2015.3127

Cited by 22 publications

(20 citation statements)

References 9 publications

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“…It is possible that a greater number of sessions in PTSD treatment would promote longer‐lasting improvement. Notably, these differences may be due to the pathophysiological differences of the two disorders, which would require unique approaches to induce therapeutic plasticity (Camprodon & Pascual‐Leone, ). Appropriately powered randomized controlled trials should be considered to empirically confirm and validate these meta‐analytical conclusions.…”

Section: Discussionmentioning

confidence: 99%

Transcranial magnetic stimulation in anxiety and trauma‐related disorders: A systematic review and meta‐analysis

et al. 2019

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Background Transcranial magnetic stimulation (TMS) has been evaluated as an effective treatment option for patients with major depressive disorder. However, there are limited studies that have evaluated the efficacy of TMS for other neuropsychiatric disorders such as anxiety and trauma‐related disorders. We reviewed the literature that has evaluated TMS as a treatment for anxiety and trauma‐related disorders. Methods We searched for articles published up to December 2017 in Embase, Medline, and ISI Web of Science databases, following the Preferred Items for Reporting of Systematic Reviews and Meta‐Analyses (PRISMA) statement. Articles ( n = 520) evaluating TMS in anxiety and trauma‐related disorders were screened and a small subset of these that met the eligibility criteria ( n = 17) were included in the systematic review, of which nine evaluated TMS in posttraumatic stress disorder (PTSD), four in generalized anxiety disorder (GAD), two in specific phobia (SP), and two in panic disorder (PD). The meta‐analysis was performed with PTSD and GAD since PD and SP had an insufficient number of studies and sample sizes. Results Among anxiety and trauma‐related disorders, TMS has been most widely studied as a treatment for PTSD. TMS demonstrated large overall treatment effect for both PTSD (ES = −0.88, 95% CI: −1.42, −0.34) and GAD (ES = −2.06, 95% CI: −2.64, −1.48), including applying high frequency over the right dorsolateral prefrontal cortex. Since few studies have evaluated TMS for SP and PD, few conclusions can be drawn. Conclusions Our meta‐analysis suggests that TMS may be an effective treatment for GAD and PTSD.

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Section: Discussionmentioning

confidence: 99%

Transcranial magnetic stimulation in anxiety and trauma‐related disorders: A systematic review and meta‐analysis

et al. 2019

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“…All APMs in our review are dopamine D2 receptor antagonists, suggesting that dopamine blockade may play a role. However, rTMS and tDCS do not directly modulate dopamine systems and instead are believed to work through glutamate and GABA modulation (92, 93). There is no clear evidence on which mechanisms are involved in CRT or CBTp but to the extent that these therapies alter cortical information processing they would also be expected to modulate glutamate and GABA systems.…”

Section: Discussionmentioning

confidence: 99%

Converging effects of diverse treatment modalities on frontal cortex in schizophrenia: A review of longitudinal functional magnetic resonance imaging studies

Kani

Shinn

Lewandowski

et al. 2017

Journal of Psychiatric Research

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Objectives A variety of treatment options exist for schizophrenia, but the effects of these treatments on brain function are not clearly understood. To facilitate the development of more effective treatment strategies, it is important to identify how brain function in schizophrenia patients is affected by the diverse therapeutic approaches that are currently available. The aim of the present article is to systematically review the evidence for functional brain changes associated with different treatment modalities for schizophrenia. Methods We searched PubMed for longitudinal functional MRI (fMRI) studies reporting on the effects of antipsychotic medications (APM), repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), cognitive remediation therapy (CRT) and cognitive behavioral therapy for psychosis (CBTp) on brain function in schizophrenia. Results Thirty six studies fulfilled the inclusion criteria. Functional alterations were observed in diverse brain regions. Across intervention modalities, changes in fMRI parameters were reported most commonly in frontal brain regions including prefrontal cortex, anterior cingulate and inferior frontal cortex. Conclusions We conclude that current treatments for schizophrenia commonly induce functional brain alterations in frontal brain regions. However, interpretability is limited by inconsistency in task and region of interest selection, and failures to replicate. Further task independent fMRI studies examining treatment effects with whole brain analysis are needed to deepen our insights.

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“…TMS with various single-pulse protocols and paired-pulse protocols is a useful tool for the assessment of physiology of the human motor system, including cortical excitability, inhibitory and excitatory mechanisms, conduction time, connectivity, and plasticity [5]. Moreover, Camprodon and Pascual-Leone [5] suppose that this tool has properties that we now need to understand across affective, behavioral, and cognitive circuits, to establish solid circuit-based models of neuropsychiatric diseases with the potential to affect clinical practice.…”

Section: Tms In Neurophysiological Research Of Schizophreniamentioning

confidence: 99%

“…Moreover, Camprodon and Pascual-Leone [5] suppose that this tool has properties that we now need to understand across affective, behavioral, and cognitive circuits, to establish solid circuit-based models of neuropsychiatric diseases with the potential to affect clinical practice.…”

Section: Tms In Neurophysiological Research Of Schizophreniamentioning

confidence: 99%

“…Another recent study found inhibitory deficits directly in the prefrontal cortex specific for schizophrenia using a combination of TMS and electroencephalography (EEG) [9]. Camprodon and Pascual-Leone [5] suppose that this multimodal combination of TMS and neuroimaging methods (EEG, magnetic resonance imaging, or positron emission tomography) can achieve TMS full potential-to measure the neurobiological effects of TMS even beyond the motor cortex.…”

Section: Tms In Neurophysiological Research Of Schizophreniamentioning

confidence: 99%

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Transcranial Magnetic Stimulation in Schizophrenia

Ustohal¹,

Svěrák²,

Albrechtová³

et al. 2016

Schizophrenia Treatment - The New Facets

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Transcranial magnetic stimulation (TMS) is a method that can be used in neurophysiological research of schizophrenia and in the treatment of some symptoms or syndromes of this mental disorder. The most important indications for TMS (or repetitive TMSrTMS) are the negative symptoms of schizophrenia and auditory hallucinations. Other less proven indications include cognitive deficit, especially working memory. This text summarizes general knowledge about (r)TMS and its use in schizophrenia. According to recent experiences, TMS is a very promising experimental and therapeutic method, but it needs further research for its optimized use.

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Multimodal Applications of Transcranial Magnetic Stimulation for Circuit-Based Psychiatry

Cited by 22 publications

References 9 publications

Transcranial magnetic stimulation in anxiety and trauma‐related disorders: A systematic review and meta‐analysis

Transcranial magnetic stimulation in anxiety and trauma‐related disorders: A systematic review and meta‐analysis

Converging effects of diverse treatment modalities on frontal cortex in schizophrenia: A review of longitudinal functional magnetic resonance imaging studies

Transcranial Magnetic Stimulation in Schizophrenia

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