Multimodal analysis of RNA sequencing data powers discovery of complex trait genetics
Daniel Munro,
Nava Ehsan,
Seyed Mehdi Esmaeili-Fard
et al.
Abstract:Transcriptome data is commonly used to understand genome function via quantitative trait loci (QTL) mapping and to identify the molecular mechanisms driving genome wide association study (GWAS) signals through colocalization analysis and transcriptome-wide association studies (TWAS). While RNA sequencing (RNA-seq) has the potential to reveal many modalities of transcriptional regulation, such as various splicing phenotypes, such studies are often limited to gene expression due to the complexity of extracting a… Show more
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