Multimethodological validation of the modified fatigue impact scale in a Danish population of people with Multiple Sclerosis

Riemenschneider, Morten; Trénel, Philipp; Nørgaard, Michael; Boesen, Finn

doi:10.1016/j.msard.2022.104012

Cited by 9 publications

(4 citation statements)

References 33 publications

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“…In this study, the LEFS score increased from 26/80 (32.5%) to 39/80 (48.8%), indicating an improvement in the patient's physical activity level, as observed in her walking, balancing, and stair climbing. Improvements in the MFIS and LEFS suggested enhanced functional abilities, especially in the LEs [30], and improved quality of life for the patient [30,31].…”

Section: Resultsmentioning

confidence: 96%

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Impact of a Six-Week Treadmill Walking Program Combined with Submaximal Inspiratory Exercise in a Prehypertensive Female Living with Multiple Sclerosis: A Case Report

Adeogun,

Bender-Burnett

2024

IJNPT

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Introduction: Multiple sclerosis (MS) can result in a range of disability, cognitive and ambulatory dysfunction, depression, fatigue, pain, and reduced quality of life. Hypertension has also been identified as a comorbidity for people living with MS. This case report investigated the impact of a six-week treadmill walking program combined with submaximal inspiratory exercise in a 39-year-old prehypertensive female living with MS. Case Description: The patient was referred for outpatient physical therapy to manage prehypertension and symptoms associated with MS. The patient completed a six-week treadmill walking program combined with submaximal inspiratory exercise. Outcomes included were systolic blood pressure (SBP), diastolic blood pressure (DBP), Numeric Pain Rating Scale (NPRS), Modified Fatigue Impact Scale (MFIS), and Lower Extremity Functional Scale (LEFS). Results: Following six weeks of intervention, the patient's resting SBP decreased from 128 mmHg to 122 mmHg and resting DBP decreased from 88 mmHg to 82 mmHg. The patient's fatigue level, measured with MFIS, improved from 57/84 to 35/84. LEFS increased from 26/80 to 39/80 with improvements in balance, walking, and stair-climbing activities. Discussion: A six-week treadmill walking program combined with submaximal inspiratory exercise effectively lowered resting blood pressure and MS-related symptoms, improving the patient's quality of life and functional capabilities.

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Section: Resultsmentioning

confidence: 96%

“…The items on the MFIS address the impact of fatigue on the patient's physical, cognitive, and psychosocial well-being. The MFIS possesses good structural, cross-cultural, and nomological validity and is suitable for multidimensional Rasch analysis [31].…”

Section: Tests and Measuresmentioning

confidence: 99%

Impact of a Six-Week Treadmill Walking Program Combined with Submaximal Inspiratory Exercise in a Prehypertensive Female Living with Multiple Sclerosis: A Case Report

Adeogun,

Bender-Burnett

2024

IJNPT

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“…However, this finding is of uncertain clinical significance because, according to recent studies, the psychosocial subscale of the MFIS has a low factor loading in exploratory factor analysis of MFIS, as well as low reliability, and should not be interpreted independently of the other subscales. 45 …”

Section: Discussionmentioning

confidence: 99%

Transcranial direct current stimulation for post-COVID fatigue: a randomized, double-blind, controlled pilot study

Oliver-Mas

Delgado‐Alonso

Delgado‐Álvarez

et al. 2023

Brain Communications

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Fatigue is one of the most frequent and disabling symptoms of post-COVID syndrome. In this study, we aimed to assess the effects of transcranial direct current stimulation on fatigue severity in a group of patients with post-COVID syndrome and chronic fatigue. We conducted a double-blind, parallel-group, sham-controlled study to evaluate the short-term effects of anodal transcranial direct current stimulation (2 mA, 20 min/day) on the left dorsolateral prefrontal cortex. The Modified Fatigue Impact Scale score was used as the primary endpoint. Secondary endpoints included cognition (Stroop test), depressive symptoms (Beck Depression Inventory), and quality of life (EuroQol-5D). Patients received eight sessions of transcranial direct current stimulation and were evaluated at baseline, immediately after the last session, and one month later. Forty-seven patients were enrolled (23 in the active treatment group and 24 in the sham treatment group); mean age was 45.66 ± 9.49 years, and 37 (78.72%) were women. The mean progression time since acute infection was 20.68 ± 6.34 months. Active transcranial direct current stimulation was associated with a statistically significant improvement in physical fatigue at the end of treatment and at one month as compared with sham stimulation. No significant effect was detected for cognitive fatigue. In terms of secondary outcomes, active transcranial direct current stimulation was associated with an improvement in depressive symptoms at the end of treatment. The treatment had no effects on quality of life. All the adverse events reported were mild and transient, with no differences between the active stimulation and sham stimulation groups. In conclusion, our results suggest that transcranial direct current stimulation on the dorsolateral prefrontal cortex may improve physical fatigue. Further studies are needed to confirm these findings and optimize stimulation protocols.

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“…A score of ≥38 points indicates clinical fatigue [ 110 ], and a change of 4 points is considered clinically relevant [ 111 ]. The Danish version of MFIS has been validated and shows good reliability [ 112 ].…”

Section: Methodsmentioning

confidence: 99%

Effects of power training in older patients with multiple sclerosis on neurodegeneration, neuromuscular function, and physical function. A study protocol for the “power training in older multiple sclerosis patients (PoTOMS) randomized control trial

Gaemelke,

Laustsen,

Feys

et al. 2024

Contemporary Clinical Trials Communications

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Multimethodological validation of the modified fatigue impact scale in a Danish population of people with Multiple Sclerosis

Cited by 9 publications

References 33 publications

Impact of a Six-Week Treadmill Walking Program Combined with Submaximal Inspiratory Exercise in a Prehypertensive Female Living with Multiple Sclerosis: A Case Report

Impact of a Six-Week Treadmill Walking Program Combined with Submaximal Inspiratory Exercise in a Prehypertensive Female Living with Multiple Sclerosis: A Case Report

Transcranial direct current stimulation for post-COVID fatigue: a randomized, double-blind, controlled pilot study

Effects of power training in older patients with multiple sclerosis on neurodegeneration, neuromuscular function, and physical function. A study protocol for the “power training in older multiple sclerosis patients (PoTOMS) randomized control trial

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