Multimarker Assessment of Diastolic Dysfunction in Metabolic Syndrome Patients

Mocan, Mihaela; Anton, Florin Petru; Suciu, Sanda; Rahaian, Rodica; Blaga, S; Fărcăş, Anca Daniela

doi:10.1089/met.2017.0060

Cited by 16 publications

(13 citation statements)

References 28 publications

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“…The influence of inflammatory factors on LVDD is a relatively new topic in the literature. The results of the first studies to appear on this subject in the last few months have focused on both animal and human populations [20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

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Inflammatory markers and left ventricular diastolic dysfunction in a family-based population study

Kloch¹,

Stolarz‐Skrzypek²,

Olszanecka³

et al. 2019

Kardiol Pol

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Background: Heart failure affects patients with normal left ventricular systolic function (heart failure with preserved ejection fraction [HFPEF]) and those with reduced ejection fraction (HFREF). The treatment of HFPEF remains an unresolved issue. Aim: We sought to determinate the relationship between inflammatory markers and left ventricular diastolic dysfunction (LVDD) in a family-based population study. Methods: A total of 303 participants from the general population (55% women, median age 49 years and 45% men, median age 40 years) underwent echocardiography and measurement of serum inflammatory markers: C-reactive protein (CRP), myeloperoxidase (MPO), and interleukin 6 (IL-6). Results: Serum IL-6 concentration correlated with peak transmitral late diastolic velocity (A) and pulmonary vein systolic-to-diastolic velocity (S/D) ratio (p < 0.01). Moreover, a significant correlation between IL-6 concentration and E/A ratio and early diastolic peak velocities of the mitral annulus displacement (E') was observed. The association of IL-6 concentration and peak transmitral early diastolic velocities (E) and the E/E' ratio (p < 0.05) was noted in men. In addition, the CRP concentration was shown to have an effect on E/A ratio in women (p < 0.05). A significant correlation between the CRP concentration and S/D ratio was observed both in women (p < 0.01) and men (p < 0.05). No significant correlation was found between the level of MPO and LVDD parameters. Additionally, only one predictive model was identified; E' was found to be dependent on IL-6, age, and heart rate in men (p < 0.001, R 2 = 0.611). Conclusions: The above results suggest that inflammation may lead to the onset of LVDD, probably via vascular endothelial dysfunction.

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Section: Discussionmentioning

confidence: 99%

“…Patients with carbohydrate disorders and predictive factors for the development of LVDD were also studied by Mocan et al [23]. High-sensitivity CRP, fibrinogen, IL-6, IL-8, Tables 2 and 3 Values represent Spearman's correlation coefficients.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory markers and left ventricular diastolic dysfunction in a family-based population study

Kloch¹,

Stolarz‐Skrzypek²,

Olszanecka³

et al. 2019

Kardiol Pol

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“…Although β2-adrenoceptors mediate vasorelaxation at the level of vascular smooth muscle, the stimulation of β2-adrenoceptors is known to increase endothelial release of NO and cause largely endotheliummediated vascular relaxation [26]. Therefore, the effect of the β2-adrenoceptor agonist salbutamol on the PWA-derived measure of wave reflection and arterial stiffness, the Aix, has been applied as a method to evaluate the influence of endothelial stimulation in the whole arterial tree [20,27,28]. In a recent study, inhaled salbutamol has induced an 8-12% decrease in the Aix in healthy subjects, but in many studies the effects on other haemodynamic variables have not been determined [26].…”

Section: Discussionmentioning

confidence: 99%

Salbutamol-mediated effects on arterial parameters: a tool for subclinical atherosclerosis detection in patients with metabolic syndrome submitted to a cardiac rehabilitation program

Cozma¹,

Pharmacy²,

Sitar-Tăut³

et al. 2018

Balneo

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Introduction. Early detection of atherosclerosis is important in patients with metabolic syndrome (MetS) because cardiovascular diseases are the main cause of mortality in these patients. Cardiac rehabilitation (CR) is one of the best known and studied interventions, which has been shown to be associated with decreased morbidity and mortality of cardiovascular disease. Salbutamolmediated effects on pulse wave represent a practical, valid and reliable non-invasive surrogate marker of subclinical atherosclerosis. Aim of the study We assessed subclinical atherosclerosis in patients with MetS vs. a control group, by measuring aortic pulse wave velocity (PWVAo), the augmentation index and central blood pressure, before and after salbutamol administration, which allows evaluation of the hemodynamic effects of inhaled salbutamol on the arterial parameters. Material and methods We conducted a clinical study on a representative sample of 30 subjects, 67% had metabolic syndrome and 33% did not have metabolic syndrome (control group). We measured all parameters of arterial stiffness: brachial augmentation index (Aixb), aortic augmentation index (Aixao), pulse wave velocity (PWVao), aortic pulse pressure (PPao), central blood pressure (SBPao), before and after administration of two inhalations of Ventolin® (salbutamol). Results The analysis of arterial stiffness parameters (Table 2) showed that PWVao before salbutamol administration was 10.60 m/s in the group with MetS, and 9.11 m/s in the control group, with no significant difference. After salbutamol administration, PWVao was 10.78 m/s in the group with MetS, and significantly lower 8.2 m/s (p=0.008), in the group without MetS. There was a significant difference between the groups regarding PPao (mmHg) before salbutamol (54.040 ± 8.5530, 66.215 ± 15.6326, p=0.03), SBPao (mmHg) before salbutamol (147.14±20.12 vs. 125.34±9.71; p<0.0001) and after salbutamol administration. (138.76±21.97 vs.121.38±8.08; p=0.005). There were no significant differences in brachial Aix (0.03±27.5 vs.-3.04±29.64, p=NS) and aortic Aix (37.72±14.04 vs.36.11±15; p=NS) between the two groups. Conclusions. Early identification of endothelial dysfunction in subjects with metabolic syndrome is important in order to prescribe an optimal cardiac rehabilitation program.

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“…Our study focused on single-marker evaluation, rather than on a multimarket strategy, for the diagnosis of LVDD. In our previous work, we assessed the potential of N-terminal pro-B-type natriuretic peptide as a diagnosis biomarker for LVDD in hypertensive patients with metabolic syndrome [32]. As in patients with metabolic syndrome, in our study group, 34% of the patients were diagnosed with diabetes mellitus (DM) and fasting glucose, along with higher sST2 levels, is associated with higher risk of CV events.…”

Section: Sst2 In Comparison Tomentioning

confidence: 99%

Short-Term Prognosis Value of sST2 for an Unfavorable Outcome in Hypertensive Patients

et al. 2020

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Background. sST2 represents a useful biomarker for the diagnosis and prognosis of patients with heart failure, but limited data is available on its role in patients with hypertension. The aim of this study is to evaluate the short-term prognosis value of sST2 for an unfavorable outcome in hypertensive patients. Methods. This was a prospective observational study which enrolled 80 patients with hypertension, who were followed for one year. All patients underwent clinical, laboratory (including sST2), and echocardiographic assessment at baseline. The patients were grouped according to the cardiovascular (CV) events reported during the follow-up: group A (with CV events) and group B (without CV events). Results. Overall, 59 CV events were reported during the follow-up period. Compared to group B, the patients in group A had significantly higher sST2 levels, a higher number of CV risk factors, and a higher left ventricle mass. Except for the diastolic dysfunction parameters, the echocardiographic findings were similar in the two groups. Patients in group A had a lower E/A ratio, larger deceleration time, and increased telediastolic pressure as quantified by the E/E′ ratio than those in group B. Multivariate logistic regression analysis showed that sST2 and fasting plasma glucose at baseline were independent predictors for the CV events reported during the follow-up period. sST2 levels > 28:5 ng/mL were associated with poor clinical outcomes (p = 0:006, Kaplan-Meier analysis). Conclusions. sST2 levels were correlated with the risk of adverse CV outcomes in hypertensive patients and may represent a useful prognostic marker in these patients.

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Multimarker Assessment of Diastolic Dysfunction in Metabolic Syndrome Patients

Cited by 16 publications

References 28 publications

Inflammatory markers and left ventricular diastolic dysfunction in a family-based population study

Inflammatory markers and left ventricular diastolic dysfunction in a family-based population study

Salbutamol-mediated effects on arterial parameters: a tool for subclinical atherosclerosis detection in patients with metabolic syndrome submitted to a cardiac rehabilitation program

Short-Term Prognosis Value of sST2 for an Unfavorable Outcome in Hypertensive Patients

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