Multilocular Cystic Nephroma and Multicystic Clear Cell Carcinoma: Two Faces of the Roman God Janus?

Stamatiou, Konstantinos; Sofras, Frank

doi:10.1177/1066896908316786

Cited by 7 publications

(4 citation statements)

References 6 publications

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“…The main differential diagnosis of mcCCRCNLMP is CCRCC with extensive cystic changes. Solid nodules of clear cells, which alter the natural septal configuration, allow differentiating CCRCC with extensive cystic changes from mcCCRCNLMP . This distinction is highly relevant, since extensively necrotic cystic CCRCCs have been shown to be capable of aggressive clinical behavior .…”

Section: Discussionmentioning

confidence: 99%

Multiple and bilateral kidney tumors with clear cells of three different histotypes: A case report with clinicopathologic and molecular study

Raspollini

Castiglione

Martignoni

et al. 2016

APMIS

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We describe a rare multicentric neoplastic disease arising bilteraly in the kidney. The patient was a 70-year-old man, who, during a period of 3 years, was treated for five independent tumors of three histotypes (three multilocular cystic clear cell renal cell neoplasms of low malignant potential, one clear cell renal cell carcinoma, and one clear cell papillary renal cell carcinoma, respectively). Pathologic diagnosis of the reported tumors was confirmed by immunohistochemical analyses, including CD10, CA IX, CK7, AMACR/RACEMASE, and 34 beta E12. Molecular detection of KRAS, BRAF, NRAS, PIK3CA, ALK, ERBB2, DDR2, MAP2K1, RET, and EGFR gene mutational analysis was also performed in all tumors.

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Section: Discussionmentioning

confidence: 99%

Multiple and bilateral kidney tumors with clear cells of three different histotypes: A case report with clinicopathologic and molecular study

Raspollini

Castiglione

Martignoni

et al. 2016

APMIS

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“…[106][107][108] The latter is typically composed of multiple cysts filled with hemorrhagic and necrotic debris and separated by irregularly thick shaggy walls composed of variable mixtures of fibrous tissue and neoplastic cells. Expansile solid nodules of clear cells, which alter the natural septal configuration, serve to differentiate extensively cystic RCC from multilocular cystic RCC, although it is clear that these 2 entities exist in a spectrum.…”

Section: New Concepts and Refinements To Existing Who (2004) Renal Cementioning

confidence: 99%

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

Srigley¹,

Delahunt²,

Eble³

et al. 2013

American Journal of Surgical Pathology

931

727

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The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of Renal Tumors (2004). Members of the group performed an exhaustive literature review, assessed the results of the preconference survey and participated in the consensus conference discussion and polling activities. On the basis of the above inputs, there was consensus that 5 entities should be recognized as new distinct epithelial tumors within the classification system: tubulocystic renal cell carcinoma (RCC), acquired cystic disease-associated RCC, clear cell (tubulo) papillary RCC, the MiT family translocation RCCs (in particular t(6;11) RCC), and hereditary leiomyomatosis RCC syndrome-associated RCC. In addition, there are 3 rare carcinomas that were considered as emerging or provisional new entities: thyroid-like follicular RCC; succinate dehydrogenase B deficiency-associated RCC; and ALK translocation RCC. Further reports of these entities are required to better understand the nature and behavior of these highly unusual tumors. There were a number of new concepts and suggested modifications to the existing World Health Organization 2004 categories. Within the clear cell RCC group, it was agreed upon that multicystic clear cell RCC is best considered as a neoplasm of low malignant potential. There was agreement that subtyping of papillary RCC is of value and that the oncocytic variant of papillary RCC should not be considered as a distinct entity. The hybrid oncocytic chromophobe tumor, which is an indolent tumor that occurs in 3 settings, namely Birt-Hogg-Dubé Syndrome, renal oncocytosis, and as a sporadic neoplasm, was placed, for the time being, within the chromophobe RCC category. Recent advances related to collecting duct carcinoma, renal medullary carcinoma, and mucinous spindle cell and tubular RCC were elucidated. Outside of the epithelial category, advances in our understanding of angiomyolipoma, including the epithelioid and epithelial cystic variants, were considered. In addition, the apparent relationship between cystic nephroma and mixed epithelial and stromal tumor was discussed, with the consensus that these tumors form a spectrum of neoplasia. Finally, it was thought that the synovial sarcoma should be removed from the mixed epithelial and mesenchymal category and placed within the sarcoma group. The new classification is to be referred to as the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia.

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“…A centrally located CCDC with invasion into the renal pelvis may be indistinguishable from an invasive transitional cell carcinoma of the renal pelvis. This distinction, however, has important implications for treatment because nephroureterectomy is indicated for urothelial carcinomas, whereas nephrectomy is performed for renal parenchymal malignancies [ 18 ]. Chromophobe renal cell carcinomas may have a spoke-like pattern in some cases.…”

Section: Discussionmentioning

confidence: 99%

CT and MRI findings of cystic renal cell carcinoma: comparison with cystic collecting duct carcinoma

Zhu

Ling

et al. 2021

Cancer Imaging

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Background Cystic renal cell carcinoma (CRCC) and cystic collecting duct carcinoma (CCDC) share similar oncogeni and some imaging findings. The aim of this study was to characterize the clinical and CT imagings features of CRCC and CCDC. Methods Thirty-three patients with CRCC and thirteen patients with CCDC with pathologically proven were retrospectively studied. Tumor characteristics were assessed. Results On CT imaging, 33 patients(100 %) with CRCC and 13 patients(100 %) with CCDC, tumors calcifications (8 vs. 9, P < 0.0001), had a clear boundary (capsule sign, 30 vs. 2, P < 0.0001), infiltrative appearance (1 vs. 13, P < 0.0001), exogenous appearance (29 vs. 3, P < 0.0001), invaded the renal pelvis or ureter (1 vs. 10, P < 0.0001), hemorrhage (1 vs. 10, P < 0.0001), had retroperitoneal lymph node or distant metastasis (2 vs. 10, P < 0.0001), thickened enhancing internal septations (31 vs. 2, P < 0.0001), and mural soft-tissue nodules (21 vs. 1, P < 0.0001). On MR imaging,13 patients(39 %) with CRCC and 4 patients(31 %) with CCDC, all CRCCs appeared hypointense on T1-weighted images and hyperintense on T2-weighted images, however, all CCDCs appeared hypointense on T1-weighted images and hypointense on T2-weighted images(P < 0.0001). 33 patients with CRCC, they were all alive from3 years to 10 years follow-up, however, 13 patients with CCDC, of which 11 patients were able to be followed up, and 9 patients expired within 5 years of the initial diagnosis and the others are currently still alive. Conclusions Distinguishing features of CRCC and CCDC included calcifications, capsule signs, infiltrative appearance, metastasis, internal septations, mural nodules and signal on CT or MR images. These imaging features may help in differentiating the two renal tumor types.

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Multilocular Cystic Nephroma and Multicystic Clear Cell Carcinoma: Two Faces of the Roman God Janus?

Cited by 7 publications

References 6 publications

Multiple and bilateral kidney tumors with clear cells of three different histotypes: A case report with clinicopathologic and molecular study

Multiple and bilateral kidney tumors with clear cells of three different histotypes: A case report with clinicopathologic and molecular study

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

CT and MRI findings of cystic renal cell carcinoma: comparison with cystic collecting duct carcinoma

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