Multilocated mature teratoma: a case report and review of the literature

Abstract

Mature teratomas are rare inclusion tumors, which have benign behaviors. Different locations of the tumor were reported in the literature. However, multiple tumor locations are extremely rare. An eight year old patient presented with an intraventricularly mature teratoma. During the six year follow up-period, two separately located masses were observed in the chest area and in the right iliac region, and both tumors were histologically diagnosed as mature teratomas. In this study, this unique case of mature teratoma presented with multiple locations in three separate body compartments. Furthermore, intraventricular dissemination with sellar and parasellar extension was observed in the third ventricle.

Mature intracranial teratoma with meningocele in a lamb

“…Respiratory, esophageal and urinary epithelium represented the endoderm, bone and muscular tissue represented the mesoderm and the keratinized stratified squamous epithelium, associated with hair follicles and sweat and sebaceous glands, represented the ectoderm. These histological characteristics are consistent with those described in the literature (REINDEL et al, 1996;COLPAN et al, 2004). To the best of our knowledge, this is the first report of intracranial teratoma with meningocele in animals.…”

“…Histologically, teratomas can be classified as mature or immature tumors. A mature teratoma consists of the complete differentiation of the ectodermal, mesodermal and endodermal elements (COLPAN et al, 2004). Immature teratoma have more undifferentiated tissue consisting of embryonic mesodermal elements and neuroectodermal tissue and have a high mitotic index (HIGGINS et al, 2017).…”

Mediastinal metastases from a primary immature teratoma of the CNS

“…Prognosis of teratomas is varied based on type, with mature teratomas being associated with a better prognosis [4] . Immature teratomas, being composed of more primitive tissue, have a greater potential for malignant transformation and not surprisingly have lower survival rates within the 50%-70% range [ 4 , 11 ]. Common primary locations of teratomas include the sacrococcygeal region as well as the abdomen; only 3.5% of teratomas are found in the CNS [11] .…”

Cerebral Falx Mature Teratoma with Rare Imaging in an Adult

“…A patient was found to have a new teratoma in corpus callosum genu during his postoperative MRI fellow-up after the initial one in pineal region was removed 7. In an eight-year-old patient with a removal history of intracranial mature teratoma, another two mature teratomas occurred separately in the chest area and in the right iliac region at six years after his intra-ventricular one was removed 20. Thus, these cases suggest that the pathogenesis of teratomas might be associated with genetic alterations.…”