Multilobulated “flower” cells in a subcutaneous mass aspirate from a cat

Fritz, David; Freeman, Kathleen; Hopfner, C; Fontaine, O. Dela; Seroka, M.; Simon, Frank A.; Musch, David C.; Rabeyrin, M

doi:10.1111/j.1939-165x.2005.tb00076.x

Cited by 4 publications

(3 citation statements)

References 8 publications

(12 reference statements)

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“…Interestingly, cytology allowed us to identify multilobate cells with clover-leaf shaped nuclei, rarely described before, that led us to consider a plasmablastic differentiation of cells. Based on two recent case reports [19,23], a suspect B-cell lymphoma with plasmablastic differentiation vs. a CP was emitted. Unfortunately, the evidence of these cells seems to be not suggestive of one or the other disease.…”

Section: Discussionmentioning

confidence: 99%

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Non Epitheliotropic B-Cell Lymphoma with Plasmablastic Differentiation vs. Cutaneous Plasmacytosis in a 12-Years-Old Beagle: Case Presentation and Clinical Review

Antognoni

Misia

Brachelente

et al. 2021

Veterinary Sciences

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Cutaneous lymphoid neoplasms and cutaneous plasmacytosis are rare in the dog; in human and in veterinary medicine, these have many clinical, cytological, histological, and phenotypic similarities, and a diagnosis of certainty is not easy. The aim of this study is to describe a case of cutaneous non epitheliotropic B-cell lymphoma (CNEBL) with plasmablastic differentiation vs. multiple cutaneous plasmacytosis (CP) in a dog, since the scarce bibliographic data on these topics. A 12-year-old male Beagle dog was presented for multiple, nodular, cutaneous, and subcutaneous, indolent masses disseminated on the whole body. Cytological, histological, flow cytometric, and immunohistochemical examinations, as well as complete radiographic evaluation, echocardiography, and abdominal ultrasound were performed. Cytology, histopathology, flow cytometric, and immunohistochemical examination, performed on the skin lesions, revealed a B-cell phenotype with plasmablastic differentiation. Nevertheless, a final diagnosis could not be achieved and it was categorized as a case of borderline CNEBL with plasmablastic differentiation versus CP. The dog was treated with a COP chemotherapeutic protocol. Total remission was obtained and relapse occurred 120 days later. To our knowledge, specific markers are actually unavailable to certainly differentiate CNEBL and CP in the dog and future studies are needed to improve knowledge on these pathologies in veterinary medicine, since prognosis and therapy are different.

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Section: Discussionmentioning

confidence: 99%

“…Unfortunately, the evidence of these cells seems to be not suggestive of one or the other disease. Lee et al [19] describe similar cells as "flower cells" in a dog diagnosed with CP, whereas Fritz et al [23] found them in a cat with a final diagnosis of cutaneous B-cell lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Non Epitheliotropic B-Cell Lymphoma with Plasmablastic Differentiation vs. Cutaneous Plasmacytosis in a 12-Years-Old Beagle: Case Presentation and Clinical Review

Antognoni

Misia

Brachelente

et al. 2021

Veterinary Sciences

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“…Variable and pleomorphic nuclear shapes including band‐shaped, lobulated, and variably segmented nuclei were suggestive of myelomonocytic differentiation. Multilobulated “flower” cells are reported in cats and dogs with cells of myelomonocytic and B‐lymphoid cell origin . Circulating neoplastic lymphocytes with indented, cerebriform nuclei can be seen rarely in dogs with epitheliotropic T‐cell lymphoma and Sézary syndrome.…”

Section: Discussionmentioning

confidence: 99%

Extreme lymphocytosis with myelomonocytic morphology in a horse with diffuse large B‐cell lymphoma

Meichner

Kraszeski

Durrant

et al. 2016

Veterinary Clinical Pathol

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An 11-year-old, 443-kg Haflinger mare was presented to the North Carolina State University Veterinary Teaching Hospital with a 2-week history of lethargy and a 3-day duration of anorexia, pyrexia, tachycardia, and ventral edema. Severe pitting edema, peripheral lymphadenopathy, and a caudal abdominal mass were noted on physical examination. An extreme leukocytosis (154.3 × 10 /μL) and microscopic hematologic findings suggestive of myelomonocytic leukemia were observed. Serum protein electrophoresis revealed a monoclonal gammopathy and urine protein electrophoresis revealed a monoclonal light chain proteinuria. Necropsy and histopathology confirmed widespread neoplastic infiltration in many organs with a heterogenous population of cells; there was no apparent evidence of bone marrow involvement. Immunohistochemistry confirmed presence of a majority of B cells with a limited antigen expression, admixed with a lower number of T cells. Molecular clonality analysis of IgH2, IgH3, and kappa-deleting element (KDE, B cell) on whole blood and KDE on infiltrated tissues revealed clonal rearrangements, and the KDE intron clones that amplified in blood and in infiltrated tissue were identical. In contrast, the clonality analysis of T-cell receptor γ revealed no clonality on blood cells and infiltrated tissues. In conjunction with the histopathologic changes, the lesion was interpreted to be composed of neoplastic B cells with a reactive T-cell population. Polymerase chain reaction testing for equine herpes virus 5 was negative. The final diagnosis was diffuse large B-cell lymphoma with a marked hematogenous component.

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Multiple cutaneous plasmacytosis with multilobated (clover‐leaf shaped) nuclei cells in a dog

Lee

Kim

et al. 2020

Veterinary Medicine & Sci

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A 12‐year‐old female Shih‐tzu dog was presented with a 2‐month history of cutaneous non‐pruritic multiple ulcerated or crusted nodules of less than 1.5 cm in diameter on eyelids, lips, abdomen, groin, thighs and perianal region. Several diagnostic tests were performed, including fine needle aspiration and skin biopsy of the cutaneous nodules. Cytologic interpretation was round cell neoplasm with multilobated (clover‐leaf shaped) nuclei. Histopathology revealed round neoplastic cells with prominent anisocytosis and anisokaryosis, and numerous mitotic figures; however, the origin of the cells was not identified. Immunohistochemical evaluation indicated that these cells were positive for CD79a and MUM‐1, but negative for CD3, CD20 and Pax 5. The patient was treated with chemotherapy, and the skin condition improved. Despite good response to chemotherapy, the patient was euthanized due to poor general health.

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Multilobulated “flower” cells in a subcutaneous mass aspirate from a cat

Cited by 4 publications

References 8 publications

Non Epitheliotropic B-Cell Lymphoma with Plasmablastic Differentiation vs. Cutaneous Plasmacytosis in a 12-Years-Old Beagle: Case Presentation and Clinical Review

Non Epitheliotropic B-Cell Lymphoma with Plasmablastic Differentiation vs. Cutaneous Plasmacytosis in a 12-Years-Old Beagle: Case Presentation and Clinical Review

Extreme lymphocytosis with myelomonocytic morphology in a horse with diffuse large B‐cell lymphoma

Multiple cutaneous plasmacytosis with multilobated (clover‐leaf shaped) nuclei cells in a dog

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