Multilevel Spinal Growth Modulation With an Anterolateral Flexible Tether in an Immature Bovine Model

Newton, Peter O.; Faro, Fran D; Farnsworth, Christine L.; Shapiro, Gary S.; Mohamad, Fazir; Parent, Stefan; Fricka, Kevin B.

doi:10.1097/01.brs.0000188267.66847.bf

Cited by 66 publications

(27 citation statements)

References 24 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9 Mechanical alteration of spinal growth with an "internal brace" placed on the convexity of the curve has been proposed as an attractive alternative to arthrodesis. 10 Various investigators have experimented with spinal growth modulation to either correct spinal deformities 11,12 or to create deformities in animal models [13][14][15][16] ; however, few studies have evaluated the resulting condition of the intervertebral disc and growth plate. Biochemical and histologic analyses of these tissues need to be performed to predict their function once the "internal brace" has been removed.…”

mentioning

confidence: 99%

Spinal Growth Modulation With an Anterolateral Flexible Tether in an Immature Bovine Model

Newton¹,

Farnsworth²,

Faro³

et al. 2008

Spine

Self Cite

108

View full text Add to dashboard Cite

Tethering resulted in vertebral wedging while maintaining spinal flexibility. Although changes in proteoglycan synthesis, collagen type distribution, and disc thickness were observed, the tethered discs had similar water content to control discs and did not demonstrate gross morphologic signs of degeneration. Growth modulation is an attractive treatment option for growing patients with scoliosis, avoiding multilevel fusions or brace wear. Strategies for fusionless scoliosis correction should preserve disc health, as adolescent patients will rely on these discs for decades after treatment.

show abstract

mentioning

confidence: 99%

Spinal Growth Modulation With an Anterolateral Flexible Tether in an Immature Bovine Model

Newton¹,

Farnsworth²,

Faro³

et al. 2008

Spine

Self Cite

108

View full text Add to dashboard Cite

show abstract

“…The extent of scoliosis creation was however modest at 10°± 6°but satisfactory in comparison to the extent of deformity induction by other growth modulation devices. Newton et al had achieved a 11°± 2°scoliosis and 16°± 2°kyphosis using a flexible untensioned anterolateral tether in a porcine model [17] and a 12°± 58 scoliosis and 5°± 68 kyphosis in an immature bovine model [18]. Driscoll et al used a novel anterolateral device to compress the vertebral body growth plate without bridging the disc in an immature porcine model.…”

Section: Discussionmentioning

confidence: 98%

Modulation of spinal shape with growth following implantation of a novel surgical implant

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Conventional large animal scoliosis models are based on asymmetric spinal tethering with ribs ligation and/or resection [11][12][13][14][15][16][17]. Methods with minimal violation of the spinal elements have recently been developed, however, they still violate the thoracic cavity and require a long observation period to obtain the deformity [16][17][18][19]. The length and size of the spine obtained after deformity creation is also taller than in human early onset scoliosis.…”

Section: Th Odent (And)mentioning

confidence: 99%

Porcine model of early onset scoliosis based on animal growth created with posterior mini-invasive spinal offset tethering A preliminary report

et al. 2011

View full text Add to dashboard Cite

Several models of scoliosis were developed in the past 10 years. In most of them, deformations are induced in old animals and required long time observation period and a chest wall ligation ± resection. The purpose of the study was to create a scoliosis model with a size similar to an early onset scoliosis and an important growth potential without chest wall injuring. An original offset implant was fixed posteriorly and connected with a cable in seven (6 ? 1 control) one-month-old Landrace pigs. The mean initial spinal length (T1-S1) was 25 cm and the mean weight was 9 kg. After 2 months observation, spinal deformities were assessed with a three dimension stereographic analysis. In four animals, the cable was sectioned and the deformities followed-up for next 2 months. No post-operative complication was observed. Mean weight growth was 10 kg/month and mean spine lengthening (T1-S1) was 7 cm/month. In 2 months, we obtained structural scoliotic curves with vertebral and disk wedging which were maximal at the apex of the curve. Mean frontal and sagittal Cobb angles was 45°. Chest wall associated deformities were similar to those observed in scoliotic deformities and were correlated to spinal deformities (p = 0.03). The cable section resulted in a partial curve regression influenced by disk elasticity and could probably be influenced by gravity loads (Decrease of the Cobb angle of 30% in the sagittal plane and 45% in the frontal plane). According to the results, the model creates a structural scoliosis and chest wall deformity that is similar to an early onset scoliosis. The spinal deformities were obtained quickly, and were consistent between animals in term of amount and characteristic.

show abstract

Multilevel Spinal Growth Modulation With an Anterolateral Flexible Tether in an Immature Bovine Model

Abstract: Given adequate bony fixation, a flexible lateral spinal tether can affect growth modulation. This technique of growth modulation may serve as a future fusionless method of correction in a growing patient with scoliosis.

Cited by 66 publications

References 24 publications

Spinal Growth Modulation With an Anterolateral Flexible Tether in an Immature Bovine Model

Spinal Growth Modulation With an Anterolateral Flexible Tether in an Immature Bovine Model

Modulation of spinal shape with growth following implantation of a novel surgical implant

Porcine model of early onset scoliosis based on animal growth created with posterior mini-invasive spinal offset tethering A preliminary report

Contact Info

Product

Resources

About