The purpose of the study was to substantiate strategic directions to overcome the asymmetry of regional development. The methodological basis involved a systemic approach that allowed, in turn, a holistic approach to clarify the linkages and patterns of regional development asymmetry and justify strategic measures to overcome it. In the results, it was found that the region's development strategy is a set of interrelated measures aimed at ensuring the principles of sustainable development, improving the quality of life, creating conditions for economic growth, ensuring the efficient use of resources, improving regional self-sufficiency, economic security and competitiveness of the region. It is argued that the region's development strategies should be based on: a) associative approach to the formation of goals and tools to achieve them; b) efficiency in the use of resources; c) participation of a wide range of stakeholders in the substantiation of strategic development directions; d) overall coordination of planning and control processes for the achievement of the set objectives. It is concluded that it is proven that the strategic directions of overcoming the asymmetry of regional development must be led by strategic thinking.