Multilayer enhanced SERS active materials: fabrication, characterization, and application to trace chemical detection

Li, Honggang; Baum, Caitlin E.; Sun, Jian; Cullum, Brian M.

doi:10.1117/12.668935

Cited by 11 publications

(7 citation statements)

References 34 publications

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“…The more sensitive substrate platforms generally have a 15% relative standard deviation (RSD; the measure of the reproducibility of an analysis) from substrate-to-substrate and SERS signal enhancements of 7 to 8 orders of magnitude. (67,68) Consequently, many researchers in academia, industry, and government have focused concerted efforts toward increasing the signal enhancement ability, reproducibility, and mass production manufacturing of substrates to increase the utility of this technique. (75,76) For the Army and first responders, such a substrate platform with increased sensitivity and reliability would be very advantageous for the detection and identification of unknowns.…”

Section: Introductionmentioning

confidence: 99%

“…(55) Because of the many sensing advantages of SERS-based techniques, significant research efforts (defense, industrial and academic) have been directed toward fabricating "better" SERS substrates for SERS-based sensor platforms. (55)(56)(57)(58)(59)(60)(61)(62)(63)(64) Some of these SERS platforms are fabricated from colloids (65) , film over nanospheres (66)(67)(68)(69) , fiber optic bundles (70) , nanoparticles, (62,(71)(72)(73)(74) and lithographically (75) produced structures. The more sensitive substrate platforms generally have a 15% relative standard deviation (RSD; the measure of the reproducibility of an analysis) from substrate-to-substrate and SERS signal enhancements of 7 to 8 orders of magnitude.…”

Section: Introductionmentioning

confidence: 99%

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Army relevant Biological Hazards Detection with Commercial SERS substrates

Farrell

Pellegrino

2012

SPIE Proceedings

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There is an increasing need and challenge for early rapid and accurate detection, identification, and quantification of chemical, biological, and energetic hazards in many fields of interest (e.g., medical, environmental, industrial, and defense applications). Increasingly to meet these challenges, researchers are turning to interdisciplinary approaches combining spectroscopy with nanoscale platforms to create technologies that offer viable and novel solutions for today's sensing needs. One technology that has gained increasing popularity to meet these needs is surface enhanced Raman scattering (SERS). SERS is particularly advantageous as it does not suffer from interferences from water, requires little to no sample preparation, is robust and can be used in numerous environments, is relatively insensitive to the wavelength of excitation employed and produces a narrow-band spectral signature unique to the molecular vibrations of the analyte. SERS enhancements (chemical and electromagnetic) are typically observed on metalized nanoscale roughened surfaces. For ideal SERS sensing, a commercially available uniform and reproducible nanoscale surface demonstrating high sensitivity are desirable. Additionally, if these surfaces can be modified for the selective sensing of hazard materials, an ideal sensor platform for dynamic in field measurements can be imagined. In this proceedings paper, preliminary efforts towards the characterization and application of commercially available next generation Klarite substrates will be demonstrated. Additionally, efforts toward chemical modification of these substrates, through peptide recognition elements, can be used for the targeted sensing of hazardous materials.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Army relevant Biological Hazards Detection with Commercial SERS substrates

Farrell

Pellegrino

2012

SPIE Proceedings

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show abstract

“…[18][19][20][21] Alternatively, metal-dielectric-metal multilayered structures have also shown enhanced SERS signals from individual particles/probes. [22][23][24][25][26] In particular, probes based on this multilayered geometry have shown enhancements in SERS signals of more than an order of magnitude, 25 compared to similar single layered metallic probes, providing the potential to further improve already advanced SERS structures such as nanostars and nanocrescents. 26 Although large enhancement factors are important to obtain detectable signals in trace and ultra-trace analyses, where background Raman and fluorescence signals associated with major constituents in the local probing volume can cause significant interference or masking of the SERS signal from the analyte of interest, controlling the reproducibility and the location of the SERS signal enhancement is also crucial.…”

Section: Introductionmentioning

confidence: 99%

Improving Sensitivity and Reproducibility of SERS Sensing in Microenvironments Using Individual, Optically Trapped Surface-Enhanced Raman Spectroscopy(SERS) Probes

2016

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Surface-enhanced Raman spectroscopy (SERS) sensors offer many advantages for chemical analyses, including the ability to provide chemical specific information and multiplexed detection capability at specific locations. However, to have operative SERS sensors for probing microenvironments, probes with high signal enhancement and reproducibility are necessary. To this end, dynamic enhancement of SERS (i.e., in-situ amplification of signal-to-noise and signal-to-background ratios) from individual probes has been explored. In this paper, we characterize the use of optical tweezers to amplify SERS signals as well as suppress background signals via trapping of individual SERS active probes. This amplification is achieved through a steady presence of a single "hot" particle in the focus of the excitation laser. In addition to increases in signal and concomitant decreases in non-SERS backgrounds, optical trapping results in an eightfold increase in the stability of the signal as well. This enhancement strategy was demonstrated using both single and multilayered SERS sub-micron probes, producing combined signal enhancements of 24-fold (beyond the native 10 SERS enhancement) for a three-layered geometry. The ability to dynamically control the enhancement offers the possibility to develop SERS-based sensors and probes with tailored sensitivities. In addition, since this trapping enhancement can be used to observe individual probes with low laser fluences, it could offer particular interest in probing the composition of microenvironments not amenable to tip-enhanced Raman spectroscopy or other scanning probe methods (e.g., intracellular analyses, etc.).

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“…The more sensitive substrate platforms generally have a 15% relative standard deviation (RSD; the measure of the reproducibility of an analysis) from substrate-to-substrate and SERS signal enhancements of 7 to 8 orders of magnitude. (60,61) Consequently, many researchers in academia, industry, and government have focused concerted efforts toward increasing the signal enhancement ability, reproducibility, and mass production manufacturing of substrates to increase the utility of this technique. (5,67) For the Army and first responders, such a substrate platform with increased sensitivity and reliability would be very advantageous for the detection and identification of unknowns.…”

mentioning

confidence: 99%

“…(48) Because of the many sensing advantages of SERS-based techniques, significant research efforts (defense, industrial and academic) have been directed toward fabricating "better" SERS substrates for SERS-based sensor platforms. (48)(49)(50)(51)(52)(53)(54)(55)(56)(57) Some of these SERS platforms are fabricated from colloids (58) , film over nanospheres (59)(60)(61)(62) , fiber optic bundles (3) , nanoparticles, (55,(63)(64)(65)(66) and lithographically (5) produced structures. The more sensitive substrate platforms generally have a 15% relative standard deviation (RSD; the measure of the reproducibility of an analysis) from substrate-to-substrate and SERS signal enhancements of 7 to 8 orders of magnitude.…”

mentioning

confidence: 99%

Targeting biological sensing with commercial SERS substrates

2012

View full text Add to dashboard Cite

There is an increasing need for rapid and accurate detection, identification, and quantification of chemical, biological, and energetic hazards in many fields of interest. To meet these challenges, researchers are combining spectroscopy with nanoscale platforms to create technologies that offer viable and novel solutions for today's sensing needs. One technology that has gained increasing popularity to meet these needs is surface enhanced Raman scattering (SERS). For ideal SERS sensing, commercially available uniform and reproducible nanoscale surface demonstrating high sensitivity are desirable. If these surfaces can be modified for the selective sensing of hazard materials, an ideal sensor platform for dynamic in field measurements can be imagined. In this proceedings paper, preliminary efforts towards the characterization and application of commercially available next generation Klarite substrates will be demonstrated and efforts towards selective sensing will be discussed. ABSTRACTThere is an increasing need and challenge for early rapid and accurate detection, identification, and quantification of chemical, biological, and energetic hazards in many fields of interest (e.g., medical, environmental, industrial, and defense applications). Increasingly to meet these challenges, researchers are turning interdisciplinary approaches combining spectroscopy with nanoscale platforms to create technologies that offer viable and novel solutions for today's sensing needs. One technology that has gained increasing popularity to meet these needs is surface enhanced Raman scattering (SERS). SERS is particularly advantageous as it does not suffer from interferences from water, requires little to no sample preparation is robust and can be used in numerous environments, is relatively insensitive to the wavelength of excitation employed and produces a narrow-band spectral signature unique to the molecular vibrations of the analyte. SERS enhancements (chemical and electromagnetic) are typically observed on metalized nanoscale roughened surfaces. For ideal SERS sensing, commercially available uniform and reproducible nanoscale surface demonstrating high sensitivity are desirable. Additionally, if these surfaces can be modified for the selective sensing of hazard materials, an ideal sensor platform for dynamic in field measurements can be imagined. In this proceedings paper, preliminary efforts towards the characterization and application of commercially available next generation Klarite substrates will be demonstrated. Additionally, efforts toward chemical modification of these substrates, through peptide recognition elements can be used for the targeting sensing of hazardous materials will be explored.

show abstract

Multilayer enhanced SERS active materials: fabrication, characterization, and application to trace chemical detection

Cited by 11 publications

References 34 publications

Army relevant Biological Hazards Detection with Commercial SERS substrates

Army relevant Biological Hazards Detection with Commercial SERS substrates

Improving Sensitivity and Reproducibility of SERS Sensing in Microenvironments Using Individual, Optically Trapped Surface-Enhanced Raman Spectroscopy(SERS) Probes

Targeting biological sensing with commercial SERS substrates

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