Multilayer drug-coated cores: A system for controlling drug release

Wan, Lucy S.C.; Lai, W.F.

doi:10.1016/0378-5173(92)90045-4

Cited by 10 publications

(3 citation statements)

References 20 publications

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“…Many ravines and pits were seen on the original particle surface (Figure A1,A2), which would cause uneven or incomplete coating and thus require additional coating materials. These ravines and pits could also deteriorate the controlled-release performance of the coated fertilizers . After the wax modification, the surface of the particles became much smoother (Figure B1–D2), which would facilitate the formation of uniform coating films for controlled-release fertilizers.…”

Section: Resultsmentioning

confidence: 99%

“…These ravines and pits could also deteriorate the controlled-release performance of the coated fertilizers. 29 After the wax modification, the surface of the particles became much smoother (Figure 1B1−D2), which would facilitate the formation of uniform coating films for controlled-release fertilizers. The morphology results suggested that wax modification of the DAP could be beneficial for the preparation and performance of CDAP.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Polyolefin Wax Modification Improved Characteristics of Nutrient Release from Biopolymer-Coated Phosphorus Fertilizers

Lu¹,

Tian²,

Liu³

et al. 2019

ACS Omega

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Coating fertilizer is an effective approach to increase the fertilizer use efficiency and reduce fertilizer application rate. However, only a few studies have focused on coating phosphorus (P) fertilizer, especially diammonium phosphate (DAP) due to its irregular shape and high specific surface area. A novel and low-cost strategy centered on wax-based surface modification and bio-based polymer coating was applied to improve the nutrient characteristics of coated DAP (CDAP). Regular DAP was modified with polyolefin wax and then coated with polyurethanes prepared from castor oil. Experimental results indicated that wax modification significantly decreased the specific surface area, angle of repose of DAP particles, increased the particle hardness, and then facilitated the formation of biopolymer-based coating. The CDAP from wax-modified DAP had better controlled-release performance compared with that from normal DAP. Findings from this study indicate that wax modification can be used as an effective technology to prepare highly efficient controlled-release P fertilizers.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Polyolefin Wax Modification Improved Characteristics of Nutrient Release from Biopolymer-Coated Phosphorus Fertilizers

Lu¹,

Tian²,

Liu³

et al. 2019

ACS Omega

View full text Add to dashboard Cite

show abstract

“…In different instances, controlled drug sedimentation was exploited via centrifugation of drug particles in a molten polymer (Hildgen and McMullen, 1995). Coated systems having non-uniform drug concentration have been prepared by spraying onto inert cores dispersions of the polymer and the drug with different concentration ratios, thus creating sequential layers with non-homogeneous drug distribution (Bogentoft and Appelgren, 1984;Dekyndt et al, 2015;Li and Tu, 1991;van Bommel et al, 1989;Van Bommel et al, 1990;Wan and Lai, 1992). Monolithic systems were 3D printed including complex structures having increasing concentrations of the release modulating materials from the periphery to the center (Deng et al, 2007;Monkhouse et al, 2001).…”

Section: Introductionmentioning

confidence: 99%