Multigenerational analysis of the functional status of male reproductive system in mice after exposure to realistic doses of manganese

Souza, Tugstênio Lima de; Batschauer, Amândia R.; Brito, Patricia Manuitt; Ribeiro, Ciro Alberto de Oliveira; Martino‐Andrade, Anderson Joel; Ortolani-Machado, Claudia Feijó

doi:10.1016/j.fct.2019.110763

Cited by 9 publications

(2 citation statements)

References 64 publications

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“…In the course of experimental work, we also found that oral exposure to Mn in the pre-and gestational periods had negative consequences on the indicators of the generative function of animals, reducing the fertility and pregnancy index. The obtained results are consistent with the works of a number of authors, in which it was demonstrated that long-term exposure to Mn can lead to a decrease in the fertility of animals (Sengupt et al, 2015;Souza et al, 2019).…”

Section: Discussionsupporting

confidence: 92%

Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development

Kazakova,

Marshinskaya,

Notova

2024

BioComm

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The study evaluated the effects of prenatal exposure to manganese (Mn) on the functional state of offspring at later stages of postnatal development (PND). Female rats were treated with MnSO4·5H2O in the diet at a dose of 1433 mg/kg starting 28 days prior to breeding and through gestation. The pregnancy proceeded normally, no physical abnormalities were observed. There was a lag in physical development of the offspring, which was characterized by a later opening of the eyes, the formation of a coat and the eruption of incisors, the weight gain was attenuated from PND 0-84. Offspring had hyperactive behavior and deterioration in spatial learning and memory. The level of Mn in the blood serum and cerebral cortex was higher than the control values by 11 % and 53 % respectively. The acetylcholinesterase level in the serum was higher by 47 %. These findings highlight the risk of prenatal exposure to subchronic doses of Mn.

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Section: Discussionsupporting

confidence: 92%

Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development

Kazakova,

Marshinskaya,

Notova

2024

BioComm

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“…dopamine oxidation) have been identified, but the available evidence is not robust enough to derive a tolerable upper intake level (UL). Male fertility is another potential target of manganese toxicity; a recent paper showed significantly reduced sperm quality in mice orally exposed to ≥ 0.13 mg MnCl 2 /kg body weight (bw)/day, with a non-observed adverse effect level (NOAEL) of 0.013 mg/kg bw/day (Souza et al, 2019). Due to the lack of a UL, it is therefore advisable that oral exposure to manganese should not increase over the background dietary intake.…”

Section: Toxicology Of Manganese and Consumer Exposurementioning

confidence: 99%

Safety and efficacy of Manganese chelates of lysine and glutamic acid as feed additive for all animal species

Bampidis¹,

Azimonti²,

Bastos³

et al. 2020

EFS2

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Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of manganese chelates of lysine and glutamic acid (Manganese‐LG) as nutritional feed additive for all animal species. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Panel was assigned to this mandate. The Panel concluded that, owing to safety considerations, the simultaneous use of both feed and water supplemented with Manganese‐LG should be avoided. Manganese‐LG showed to be safe for chickens for fattening up to the maximum authorised levels in the EU for manganese in feed (150 mg/kg); however, since a margin of safety could not be derived, the conclusions could not be extrapolated/extended to other categories/species. The data showed that Manganese‐LG does not increase nor change the patterns of manganese tissue deposition when administered up to the maximum level allowed in the EU; therefore, the Panel concluded that the additive is safe for consumers of tissues and products from animals fed the additive up to the total manganese content in feed authorised in the EU. Owing to the manganese and nickel content of Manganese‐LG, the Panel concluded that the handling of the additive poses a risk to users by inhalation and shall be considered as a skin and respiratory sensitiser; the data showed that the additive is irritant to eye and non‐irritant to skin. Manganese‐LG, intended to substitute other authorised manganese additives, will not further increase the environmental burden of manganese; the Panel considered that the use of the additive in animal nutrition would not pose an additional risk for the environment. The Panel concluded that the additive is efficacious in chickens for fattening; this conclusion can be extrapolated/extended to other categories/species. The FEEDAP Panel posed a recommendation concerning the description of the additive.

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Zinc transporters ZIPT-2.4 and ZIPT-15 are required for normal C. elegans fecundity

Sue

Wignall

Woodruff

et al. 2022

J Assist Reprod Genet

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Multigenerational analysis of the functional status of male reproductive system in mice after exposure to realistic doses of manganese

Cited by 9 publications

References 64 publications

Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development

Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development

Safety and efficacy of Manganese chelates of lysine and glutamic acid as feed additive for all animal species

Zinc transporters ZIPT-2.4 and ZIPT-15 are required for normal C. elegans fecundity

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