Multigeneration Studies on the Effect of Dietary DDT on the Vitamin A Status of the Weanling Rat

Phillips, W. E. J.; Hatina, G. V.; Villeneuve, D. C.; Grant, Donald L.

doi:10.1139/y71-044

Cited by 7 publications

(1 citation statement)

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“…It is well known that organochlorine compounds including PCB cause the reduction of hepatic vitamin A content (7,9,10,34) and also that these compounds induce the operation of the hepatic microsomal mixed function oxidase system as a common action. Therefore, we presumed that microsomal mixed function oxidases might be associated with the reduction of hepatic vitamin A caused by PCB administration, that is, vitamin A would be metabolized to inactive metabolites by the oxidases, resulting in the decrease of hepatic vitamin A content (7).…”

Section: Resultsmentioning

confidence: 99%

Influence of dietary antioxidants on polychlorinated biphenyls (PCB)-induced hepatic lipid peroxide formation and vitamin A reduction in rats.

Saito

Ikegami

Ito

et al. 1982

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThis paper describes experiments designed to characterize the effect of dietary antioxidants on lipid peroxide formation and vitamin A reduction in the liver of rats fed on diets containing polychlorinated biphenyls (PCB). Rats were given 0.025% PCB diets supplemented with dietary antioxidants, for 2 weeks. The antioxidants used were as follows: 10mg% (basal and usual level), 50mg% and 100mg% of vitamin E, and 50mg% of DPPD and tinoridine respectively. A marked liver enlargement and a significant increase of total liver lipid content were observed in the PCB-fed groups irrespective of the levels of vitamin E and kinds of antioxidants, suggesting that antioxidants were ineffective in preventing the development of fatty liver. Endogeneous lipid peroxide contents in the liver of rats receiving the diets containing 10mg% vitamin E, DPPD, and tinoridine with PCB increased significantly, whereas no increase was found with the 50 and 100mg% vitamin E diets with PCB. Hepatic glutathione peroxidase activity was unaffected by PCB and dietary antioxidants. No increase in hepatic vitamin E content occurred in the PCB groups with the addition of 10mg% vitamin E, DPPD, and tinoridine. However, dietary supplementation of vitamin E at higher levels caused an elevation of hepatic vitamin E content and a further increase was observed on the addition of PCB. These results suggest that a sufficiently high level of vitamin E suppresses the increment of the endogeneous lipid peroxide content in the liver of rats fed PCB. On the other hand, the administration of PCB to rats resulted in a significant decrease in hepatic vitamin A content regardless of the levels of 1 Polychlorinated biphenyls toxicity and nutrition . XIV. Polychlorinated biphenyls toxicity and vitamin A (7).

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Section: Resultsmentioning

confidence: 99%