Multifunctional two-component in-situ hydrogel for esophageal submucosal dissection for mucosa uplift, postoperative wound closure and rapid healing

Lei, Xiongxin; Hu, Juanjuan; Zou, Chen-Yu; Jiang, Yanlin; Zhao, Long-Mei; Zhang, Xiuzhen; Li, Ya-Xing; Peng, An-Ni; Song, Yuting; Huang, Liping; Li‐Ling, Jesse; Xie, Huiqi

doi:10.1016/j.bioactmat.2023.04.015

Cited by 5 publications

(1 citation statement)

References 49 publications

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“…Naturally abundant sodium alginate (SA) is a linear polysaccharide extracted from brown seaweeds . The molecular units of β-D-mannuronic acid (M unit) and α-L-guluronic acid (G unit) ensure SA free of neurotoxicity, good biocompatibility, and biodegradability. − These features endow alginate fibers excellent characteristics including skin-friendliness, moisture absorption, antibacterial, as well as renewability. , Alginate fibers become ideal candidates for rapid wound healing, cosmetics, environmental protection, tumor therapy, and other fields. − Compared with other biobased fibers, the relatively lower mechanical property limits their applications.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembly Reinforced Alginate Fibers for Enhanced Strength, Toughness, and Bone Regeneration

Cui,

Liu,

Xie

et al. 2024

Biomacromolecules

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Material reinforcement commonly exists in a contradiction between strength and toughness enhancement. Herein, a reinforced strategy through self-assembly is proposed for alginate fibers. Sodium alginate (SA) microstructures with regulated secondary structures are assembled in acidic and ethanol as reinforcing units for alginate fibers. Acidity increases the flexibility of the helix and contributes to enhanced extendibility. Ethanol is responsible for formation of a stiff β-sheet, which enhances the modulus and strength. The structurally engineered SA assembly exhibits robust mechanical compatibility, and thus reinforced alginate fibers possess an improved tensile strength of 2.1 times, a prolonged elongation of 1.5 times, and an enhanced toughness of 3.0 times compared with SA fibers without reinforcement. The reinforcement through self-assembly provides an understanding of strengthening and toughening mechanism based on secondary structures. Due to a similar modulus with bones, reinforced alginate fibers exhibit good efficacy in accelerating bone regeneration in vivo.

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