Multifunctional titanium phosphate nanoparticles for site-specific drug delivery and real-time therapeutic efficacy evaluation

Cheng, Fang; Sun, Panpan; Xiong, Wei‐Wei; Zhang, Yi; Zhang, Qiao; Yao, Weifeng; Cao, Yudan; Zhang, Li

doi:10.1039/c8an02450b

Cited by 7 publications

(3 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, the therapeutic efficacy can be monitored in real-time as is revealed by the targeted delivery of chemotherapeutic drugs by the multifunctional titanium phosphate nanoparticle. These were designed for cellular uptake and cytotoxicity as the nanoparticles exhibited high drug loading capacity and enhanced cell uptake mediated by folate-receptor [58]. In another typical case, zinc oxide (ZnO) as such was found to have inherent cytotoxicity towards cancer cells by inducing apoptosis.…”

Section: Site-specific Cytotoxicitymentioning

confidence: 99%

Nanoparticles in Clinical Translation for Cancer Therapy

Mundekkad

Cho

2022

IJMS

121

View full text Add to dashboard Cite

The advent of cancer therapeutics brought a paradigm shift from conventional therapy to precision medicine. The new therapeutic modalities accomplished through the properties of nanomaterials have extended their scope in cancer therapy beyond conventional drug delivery. Nanoparticles can be channeled in cancer therapy to encapsulate active pharmaceutical ingredients and deliver them to the tumor site in a more efficient manner. This review enumerates various types of nanoparticles that have entered clinical trials for cancer treatment. The obstacles in the journey of nanodrug from clinic to market are also reviewed. Furthermore, the latest developments in using nanoparticles in cancer therapy are also highlighted.

show abstract

Section: Site-specific Cytotoxicitymentioning

confidence: 99%

Nanoparticles in Clinical Translation for Cancer Therapy

Mundekkad

Cho

2022

IJMS

121

View full text Add to dashboard Cite

show abstract

“…Multifunctional NPs have gained interest as a promising approach for the treatment of liver disease, and various types of NPs are under investigation for this purpose. Multifunctional NPs targeting liver disease, with functions such as drug delivery [149], imaging [150] research. The in vivo behavior and effects of multifunctional NPs in targeting liver disease are affected by several factors, including their size, shape, surface modifications, charging properties, and constituent materials [152].…”

Section: Multifunctional Nanoparticlesmentioning

confidence: 99%

Nanomaterials for Targeting Liver Disease: Research Progress and Future Perspectives

Wu¹,

Zhang²,

He³

et al. 2023

Nano Biomedicine and Engineering

View full text Add to dashboard Cite

Liver disease is a significant global health issue that affects the liver and contributes to approximately 2 million deaths worldwide each year. Although treatment options including surgery and medication are available, effective treatment remains a challenge because of limitations of the traditional drug-delivery methods, such as uneven and nonspecific drug distribution, which lead to negative effects on healthy tissues and a reduction in drug bioavailability. Nanotechnology provides a promising solution for targeted drug delivery to the liver, which has unique anatomical and physiological structures that render it an ideal target for nanomedicine. Several categories of nanomaterials, including inorganic nanomaterials, polymer nanomaterials, and multifunctional nanoparticles (NPs), have been studied as potential agents for targeting this organ in the context of liver diseases. Using surface modification and functionalization, nanomaterials can be selectively targeted to liver tissue or hepatocytes, thus delivering drugs, and enhancing their efficacy while minimizing their side effects. Nanomaterials exhibit numerous benefits; however, their stability and toxicity pose potential risks to living organisms result in adverse effects, such as protein adsorption, and inflammation. Despite the challenges inherent to the development of nanomaterials, ongoing research and development have a great potential for the liver-targeted treatment of liver diseases through the use of nanotechnology. In this review, we first describe the nanomaterials used to target liver diseases, i.e., metallic NPs, ceramic nanomaterials, micelles, polysaccharides, liposomes, dendrimers, carbon nanotubes, and multifunctional NPs. Moreover, the mechanisms for nanomaterials target liver disease are discussed. Finally, this review discusses the current challenges and prospects for future research directions in this field.

show abstract

“…Targeted therapeutic delivery system is a key approach to accumulating therapeutics into the site of action in order to boost the therapeutic efficacy. The post-fabrication of nanocarriers by using biomolecules and ligands (i.e., folic acid, hyaluronic acid, and antibody) is a promising strategy, which can precisely accumulate nanomaterials at a specific tissue [ 8 , 167 , 168 ]. For example, the conjugation of CD133 monoclonal antibodies on black TiO 2 nanoparticles to target the transmembrane glycoprotein highly expressed at pancreatic cancer stem cells has been developed to guide the nanoparticles for a site-specific cancer therapy [ 12 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Kafshgari

Goldmann

2020

Nano-Micro Lett.

View full text Add to dashboard Cite

HIGHLIGHTS • Multifunctional TiO 2 nanostructures hold promise for advancing a wide range of biomedical applications due to a feasible integration of distinct theranostic features. • Fabrication and post-fabrication strategies implemented to generate multifunctional TiO 2 nanostructures for a broad range of biomedical applications are briefly outlined. The opportunities and challenges of TiO 2 nanomaterials are highlighted in order to open the possibility of clinical translation. ABSTRACT Titanium dioxide (TiO 2 ) nanostructures exhibit a broad range of theranostic properties that make them attractive for biomedical applications. TiO 2 nanostructures promise to improve current theranostic strategies by leveraging the enhanced quantum confinement, thermal conversion, specific surface area, and surface activity. This review highlights certain important aspects of fabrication strategies, which are employed to generate multifunctional TiO 2 nanostructures, while outlining post-fabrication techniques with anemphasis on their suitability for nanomedicine. The biodistribution, toxicity, biocompatibility, cellular adhesion, and endocytosis of these nanostructures, when exposed to biological microenvironments, are examined in regard to their geometry, size, and surface chemistry. The final section focuses on recent biomedical applications of TiO 2 nanostructures, specifically evaluating therapeutic delivery, photodynamic and sonodynamic therapy, bioimaging, biosensing, tissue regeneration, as well as chronic wound healing.

show abstract

Multifunctional titanium phosphate nanoparticles for site-specific drug delivery and real-time therapeutic efficacy evaluation

Abstract: Folic acid (FA)-functionalized DHE-modified TiP (TiP-PAH-DHE-FA) nanoparticles were synthesized for site-specific drug delivery and real-time therapeutic efficacy evaluation.

Cited by 7 publications

References 48 publications

Nanoparticles in Clinical Translation for Cancer Therapy

Nanoparticles in Clinical Translation for Cancer Therapy

Nanomaterials for Targeting Liver Disease: Research Progress and Future Perspectives

Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Contact Info

Product

Resources

About