Multifunctional Thermosensitive Liposomes Based on Natural Phase-Change Material: Near-Infrared Light-Triggered Drug Release and Multimodal Imaging-Guided Cancer Combination Therapy

Abstract

Multifunctional theranostic nanoplatforms (NPs) in response to environment stimulations for ondemand drug release are highly desirable. Herein, the nearinfrared (NIR)-absorbing dye, indocyanine green (ICG), and the antitumor drug, doxorubicin (DOX), were efficiently coencapsulated into the thermosensitive liposomes based on natural phase-change material. Folate and conjugated gadolinium (Gd) chelate-modified liposome shells enhance active targeting and magnetic resonance performance of the NPs while maintaining the size of the NPs. The ICG/DOXloaded and gadolinium chelate conjugated temperaturesensitive liposome nanoplatforms (ID@TSL-Gd NPs) exhibited NIR-triggered drug release and prominent chemo-, photothermal, and photodynamic therapy properties. With the coencapsulated ICG, DOX, and the conjugated gadolinium chelates, the ID@TSL-Gd NPs can be used for triple-modal imaging (fluorescence/photoacoustic/magnetic resonance imaging)-guided combination tumor therapy (chemotherapy, photothermotherapy, and photodynamic therapy). After tail vein injection, the ID@TSL-Gd NPs accumulated effectively in subcutaneous HeLa tumor of mice. The tumor was effectively suppressed by accurate imaging-guided NIR-triggered phototherapy and chemotherapy, and no tumor regression and side effects were observed. In summary, the prepared ID@TSL-Gd NPs achieved multimodal imaging-guided cancer combination therapy, providing a promising platform for improving diagnosis and treatment of cancer.

AS1411 aptamer-modified theranostic liposomes co-encapsulating manganese oxide nano-contrast agent and paclitaxel for MRI and therapy of cancer

“…[4][5][6][7] Except for the use as a drug delivery carrier, theranostic liposomes have been concerned more and more in recent years due to the demand of the simultaneous diagnosis and therapy. Such theranostic liposomes are commonly obtained by the co-encapsulation of drugs and imaging molecules, such as uorescent quantum dots, 8,9 magnetic resonance imaging contrast agents (MRI CAs), [10][11][12][13] CT imaging contrast agents, 14 photoacoustic imaging CAs, 15 and ultrasound imaging CAs. 16 Among them, MRI-based theranostic liposomes own special advantages, because MRI is a widely used non-invasive medical imaging technique in clinical diagnosis.…”

Recent Advances in Organic/Composite Phase Change Materials for Energy Storage

“…Some aspects have been discussed in published studies: classification of PCMs, encapsulation shell materials, microencapsulation techniques, PCM microcapsules' characterizations, and thermal applications. [95][96][97][98][99][100][101][102][103][104][105][106][107][108][109][110] This review aims to help the researchers from various fields better understand the PCM microcapsules and provides critical guidance for utilizing this technology for future thermal energy storage.…”

An NIR‐II‐Emissive Photosensitizer for Hypoxia‐Tolerant Photodynamic Theranostics

“…As both COi6‐4Cl NPs and ICG can be irradiated by 808 nm laser, the ROS quantum yield (Φ ∆ ) of COi6‐4Cl NPs can be calculated by the comparison with ICG (Φ ∆ of 0.2% according to the previous report). [ 17 ] The result revealed that COi6‐4Cl NPs showed a Φ ∆ of 2.7%, which was 13‐fold higher than that of ICG (Figure S10, Supporting Information). Moreover, 20 and 60 wt% loading COi6‐4Cl NPs showed very similar Φ ∆ values (2.7% vs 2.3%) when the molar concentrations of COi6‐4Cl were kept constant, which indicated that the photosensitizing properties of COi6‐4Cl were barely affected by the aggregation state.…”