Multifunctional supramolecular vesicles for combined photothermal/photodynamic/hypoxia-activated chemotherapy

Wang, Qi; Tian, Lu; Xu, Jingzeng; Xia, Bing; Li, Jie; Lu, Feng; Lü, Xiaomei; Wang, Wenjun; Huang, Wei; Fan, Quli

doi:10.1039/c8cc05560b

Cited by 84 publications

(47 citation statements)

References 32 publications

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“…In particular, mitochondria are susceptible to ROS, which include peroxides ($O 2 ), superoxide ($O 3 ), the hydroxyl radical ($OH), and singlet oxygen ( 1 O 2 ). 71,72 Photosensitizers are one kind of the most popular molecules for producing ROS. Fan's group prepared a supramolecular vesicle based on pillar [5]arene and an NIR-absorbing diketopyrrolopyrrole (DPP)-based guest G, and finally the hypoxiaactivated prodrug tirapazamine (TPZ) was encapsulated into the vesicle.…”

Section: Mof Nanocarriers For Stimuli-responsive Drug Deliverymentioning

confidence: 99%

“…Fan's group prepared a supramolecular vesicle based on pillar [5]arene and an NIR-absorbing diketopyrrolopyrrole (DPP)-based guest G, and finally the hypoxiaactivated prodrug tirapazamine (TPZ) was encapsulated into the vesicle. 71 Once the system was irradiated by 660-nm laser, 1 O 2 molecules were produced to treat cancer. Rui et al designed a photodynamic therapy supramolecular vesicle.…”

Section: Mof Nanocarriers For Stimuli-responsive Drug Deliverymentioning

confidence: 99%

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Stimuli-Responsive Drug-Delivery Systems Based on Supramolecular Nanovalves

Song

Yang

2019

Matter

187

128

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From motor proteins to molecular machines, supramolecular chemistry has been revealed as a remarkable link to bridge the gap between biology, chemistry, and materials. Taking inspiration from the dynamic, reversible, and directional manner of non-covalent interactions that can respond to diversiform external stimuli, supramolecular nanovalves installed on the surface of inorganic or hybrid nanocarriers have received extensive attention in stimuli-responsive delivery of small drug molecules, implying their outspread bioapplications in cancer/gene therapy, biomedical application, and antimicrobial regulations. The state of supramolecular nanovalves could be well regulated by switching the conformation or the assembled/disassembled state of the assemblies. This tutorial review lays the foundation for a better understanding of the significant and typical intelligent drug-delivery systems immobilized with supramolecular polymers or supramolecular pseudorotaxanes as the gating entities of nanovalvebased molecular machines, by showing their chemical structures, operation modes, and release modalities triggered by various actuations at molecular scale. In particular, relevant perspectives of supramolecular therapeutics will also be elaborated upon.

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Section: Mof Nanocarriers For Stimuli-responsive Drug Deliverymentioning

confidence: 99%

Section: Mof Nanocarriers For Stimuli-responsive Drug Deliverymentioning

confidence: 99%

Stimuli-Responsive Drug-Delivery Systems Based on Supramolecular Nanovalves

Song

Yang

2019

Matter

187

128

View full text Add to dashboard Cite

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“…PAI can overcome the traditional optical penetration limitations (e.g., fluorescence imaging) since it detects phonons rather than photons under light excitation, providing superior spatial resolution, high contrast, and deep tissue penetration [7,[9][10][11]. To date, various optical agents have been developed for PAI/PTT theranostics, including small molecule dyes, metallic nanoparticles, and carbon nanomaterials [12][13][14][15][16]. Nevertheless, small molecule dyes usually suffer from photobleaching, while metallic nanoparticles encounter severe biotoxicity and carbon nanomaterials have broad PAI spectra without a specific wavelength and a low extinction coefficient for PAI and PTT [17,18].…”

Section: Introductionmentioning

confidence: 99%

RBC Membrane Camouflaged Semiconducting Polymer Nanoparticles for Near-Infrared Photoacoustic Imaging and Photothermal Therapy

Zheng

Wei

et al. 2020

Nano-Micro Lett.

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HIGHLIGHTS • A narrow bandgap electron donor-acceptor (D-A) semiconducting polymer nanoparticle (SPN) coated with red blood cell membrane (RBCM) for photoacoustic imaging and photothermal therapy. • The D-A structure endows SPN with excellent near-infrared absorbance, high photothermal conversion ability, and good photothermal stability. • The RBCM endows SPN with good biocompatibility, prolonged blood circulation, and improved tumor accumulation, while the small size structure endows SPN with deep tumor penetration and rapid clearance from body.

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“…Local hyperthermia can disassemble amyloid deposits by interfering with their growth . Many breakthroughs in the research and applications of photothermal agents have been reported . Nevertheless, materials currently under investigation for photothermal disintegration of matured fibrils are limited to gold and carbon‐based nanostructures.…”

Section: Introductionmentioning

confidence: 99%

Engineering Versatile Nanoparticles for Near‐Infrared Light‐Tunable Drug Release and Photothermal Degradation of Amyloid β

Lai

Zhu

et al. 2020

Adv Funct Materials

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Nanomedicines that inhibit/disassemble amyloid β (Aβ) aggregates in Alzheimer's disease (AD) are highly desirable yet remain challenging. Therapeutic efficacy and systemic delivery of reported molecules and nanoparticles (NPs) are hampered by various challenges, including low biocompatibility, off‐target toxicity, and lack of specificity. Herein, a versatile NP is designed by integrating high Aβ‐binding affinity, stimuli‐responsive drug release, and photothermal degradation properties for efficient disassembly of Aβ. Near‐infrared (NIR)‐absorbing conjugated polymer PDPP3T‐O14 serves as a photothermal core while thermal‐responsive polymer 1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphocholine at the outer layer as the NIR‐stimuli gatekeeper. Curcumin, an inhibitor of Aβ aggregation, is loaded into the NP with high encapsulation efficiency. The 5‐mer β‐sheet breaker peptides LPFFD (Leu‐Pro‐Phe‐Phe‐Asp) having high binding affinity toward Aβ are further anchored onto the surface of polyethylene glycol‐lipid shell for active Aβ‐targeting. The resultant NPs exhibit good Aβ‐targeting ability and obvious photothermal dissociation effect together with Aβ aggregation‐dependent fluorescence detection capability. Upon NIR laser irradiation, entrapped curcumin can be effectively released from the unconsolidated NPs to enhance the anti‐amyloid activity. In vitro studies demonstrate that the NPs dramatically lower Aβ‐induced cytotoxicity of PC12 cells, and therefore show great potential for the application in AD treatment.

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Multifunctional supramolecular vesicles for combined photothermal/photodynamic/hypoxia-activated chemotherapy

Cited by 84 publications

References 32 publications

Stimuli-Responsive Drug-Delivery Systems Based on Supramolecular Nanovalves

Stimuli-Responsive Drug-Delivery Systems Based on Supramolecular Nanovalves

RBC Membrane Camouflaged Semiconducting Polymer Nanoparticles for Near-Infrared Photoacoustic Imaging and Photothermal Therapy

Engineering Versatile Nanoparticles for Near‐Infrared Light‐Tunable Drug Release and Photothermal Degradation of Amyloid β

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