Multifunctional superparamagnetic nanocarriers with folate-mediated and pH-responsive targeting properties for anticancer drug delivery

Guo, Miao; Que, Chailu; Wang, Chenhong; Liu, Xiaozhou; Yan, Husheng; Liu, Keliang

doi:10.1016/j.biomaterials.2010.09.077

Cited by 133 publications

(60 citation statements)

References 28 publications

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“…4). Folate conjugation significantly increased nanoparticle cytotoxicity against human cervical carcinoma HeLa cells (Guo et al, 2011). (Guo et al, 2011).…”

Section: Passive Targetingmentioning

confidence: 98%

“…Recently, our group reported multilayer MFMNPs with a folate-modified surface and doxorubicin (an anticancer chemotherapeutic agent) loaded in the inner shell ( Fig. 3) (Guo et al, 2011). The folateconjugated MFMNPs displayed a much greater cellular uptake than nonfolate-conjugated MFMNPs by a folate receptor-mediated endocytosis process (Fig.…”

Section: Passive Targetingmentioning

confidence: 99%

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Multifunctional Magnetic Hybrid Nanoparticles as a Nanomedical Platform for Cancer-Targeted Imaging and Therapy

Yan¹,

Guo²,

Liu³

2012

Biomedical Science, Engineering and Technology

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“…4). Folate conjugation significantly increased nanoparticle cytotoxicity against human cervical carcinoma HeLa cells (Guo et al, 2011). (Guo et al, 2011).…”

Section: Passive Targetingmentioning

confidence: 98%

Section: Passive Targetingmentioning

confidence: 99%

Multifunctional Magnetic Hybrid Nanoparticles as a Nanomedical Platform for Cancer-Targeted Imaging and Therapy

Yan¹,

Guo²,

Liu³

2012

Biomedical Science, Engineering and Technology

Self Cite

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“…26,48,49 However, this microvasculature lacks the structural organization of normal blood vessels, exhibiting irregular diameters and branching patterns that compromise the integrity of the vessels. 16,48,50 The endothelial cells found in the blood vessels of normal tissue may have gaps between them that are approximately 7-10 nm in size and are thus referred to as tight junctions. In tumor microvasculature, however, these gaps can range up to a few hundred nanometers, allowing the preferential extravasation of nanosystems in tumor tissue.…”

Section: Passive Targetingmentioning

confidence: 99%

“…[31][32][33]46,50 These functionalized nanosystems are thereby able to capitalize on the presence of receptors that are overexpressed, or expressed specifically, on the surface of the specific cancer subtype that is being targeted, by the formation of a ligandreceptor complex. Ideally, the target for antineoplastic drugs should be essential to the survival of tumor cells, as well as specific to tumor cells.…”

mentioning

confidence: 99%

Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors

Frank¹,

Tyagi²,

Tomar³

et al. 2014

IJN

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Nanotechnology, although still in its infantile stages, has the potential to revolutionize the diagnosis, treatment, and monitoring of disease progression and success of therapy for numerous diseases and conditions, not least of which is cancer. As it is a leading cause of mortality worldwide, early cancer detection, as well as safe and efficacious therapeutic intervention, will be indispensable in improving the prognosis related to cancers and overall survival rate, as well as health-related quality of life of patients diagnosed with cancer. The development of a relatively new field of nanomedicine, which combines various domains and technologies including nanotechnology, medicine, biology, pharmacology, mathematics, physics, and chemistry, has yielded different approaches to addressing these challenges. Of particular relevance in cancer, nanosystems have shown appreciable success in the realm of diagnosis and treatment. Characteristics attributable to these systems on account of the nanoscale size range allow for individualization of therapy, passive targeting, the attachment of targeting moieties for more specific targeting, minimally invasive procedures, and real-time imaging and monitoring of in vivo processes. Furthermore, incorporation into nanosystems may have the potential to reintroduce into clinical practice drugs that are no longer used because of various shortfalls, as well as aid in the registration of new, potent drugs with suboptimal pharmacokinetic profiles. Research into the development of nanosystems for cancer diagnosis and therapy is thus a rapidly emerging and viable field of study.

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“…Therefore, SPIONs surface treatment with (3-aminopropyl) triethoxysilane (APTES) increases the presentation time of SPIONs in blood circulation. In addition, long-circulating nanocarriers such as polyethylene glycol (PEG) modifi ed SPIONs can preferentially accumulate in the tumor sites through the leaky tumor vasculature by the enhanced permeability and retention (EPR) effect, known as passive targeting [3][4][5]. The PEG coating could enhance the compatibility between nanoparticles and aqueous medium, prevent particle surface from oxidation, reduce toxicity, and facilitate storage or transport [6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of radiolabeled, folic acid-PEG conjugated, amino silane coated magnetic nanoparticles in tumor bearing Balb/C mice

et al. 2015

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Abstract. To design a potent agent for positron emission tomography/magnetic resonance imaging (PET/MRI) imaging and targeted magnetic hyperthermia-radioisotope cancer therapy radiolabeled surface modifi ed superparamagnetic iron oxide nanoparticles (SPIONs) were used as nanocarriers. Folic acid was conjugated for increasing selective cellular binding and internalization through receptor-mediated endocytosis. SPIONs were synthesized by the thermal decomposition of tris (acetylacetonato) iron (III) to achieve narrow and uniform nanoparticles. To increase the biocompatibility of SPIONs, they were coated with (3-aminopropyl) triethoxysilane (APTES), and then conjugated with synthesized folic acid-polyethylene glycol (FA-PEG) through amine group of (3-aminopropyl) triethoxysilane. Finally, the particles were labeled with 64 Cu (t 1/2 = 12.7 h) using 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono (N-hydroxy succinimide ester) DOTA-NHS chelator. After the characterization of SPIONs, their cellular internalization was evaluated in folate receptor (FR) overexpressing KB (established from a HeLa cell contamination) and mouse fi broblast cell (MFB) lines. Eventually, active and passive targeting effects of complex were assessed in KB tumor-bearing Balb/C mice through biodistribution studies. Synthesized bare SPIONs had low toxicity effect on healthy cells, but surface modifi cation increased their biocompatibility. Moreover, KB cells viability was reduced when using folate conjugated SPIONs due to FR-mediated endocytosis, while having little effect on healthy cells (MFB). Moreover, this radiotracer had tolerable in vivo characteristics and tumor uptake. In the receptor blocked case, tumor uptake was decreased, indicating FR-specifi c uptake in tumor tissue while enhanced permeability and retention effect was major mechanism for tumor uptake.

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Multifunctional superparamagnetic nanocarriers with folate-mediated and pH-responsive targeting properties for anticancer drug delivery

Cited by 133 publications

References 28 publications

Multifunctional Magnetic Hybrid Nanoparticles as a Nanomedical Platform for Cancer-Targeted Imaging and Therapy

Multifunctional Magnetic Hybrid Nanoparticles as a Nanomedical Platform for Cancer-Targeted Imaging and Therapy

Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors

Synthesis and evaluation of radiolabeled, folic acid-PEG conjugated, amino silane coated magnetic nanoparticles in tumor bearing Balb/C mice

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