Multifunctional sulfonated polyetheretherketone coating with beta-defensin-14 for yielding durable and broad-spectrum antibacterial activity and osseointegration

Yuan, Xiangwei; Ouyang, Liping; Luo, Yao; Sun, Zhenjie; Yang, Chao; Wang, Jiaxing; Liu, Xuanyong; Zhang, Xianlong

doi:10.1016/j.actbio.2019.01.016

Cited by 95 publications

(56 citation statements)

References 51 publications

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“…The effect of Ga (III) incorporation in the CS coatings on the viable counts of Gram-negative Escherichia coli was investigated using the colony forming unit test, considering pure CS coatings as a control. The experiment was performed with little modification from a previously reported method by Yuan et al [42]. Prior to the experiment, all samples were sterilized using UV treatment for 1 h. Isolated colonies of the test strains were cultured in a nutrient broth (lysogeny broth (LB) medium, Carl Roth GmbH, Karlsruhe, Germany) overnight at 100 rpm and 37 • C in order to obtain a fresh bacteria suspension suitable for inoculation.…”

Section: Antibacterial Assaymentioning

confidence: 99%

Electrophoretic Deposition and Characterization of Functional Coatings Based on an Antibacterial Gallium (III)-Chitosan Complex

et al. 2020

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Despite their broad biomedical applications in orthopedics and dentistry, metallic implants are still associated with failures due to their lack of surface biofunctionality, leading to prosthesis-related microbial infections. In order to address this issue, the current study focuses on the fabrication and characterization of a novel type of antibacterial coating based on gallium (III)-chitosan (Ga (III)-CS) complex layers deposited on metallic substrates via electrophoretic deposition (EPD). Aiming for the production of homogeneous and monophasic coatings, a two step-procedure was applied: the first step involved the synthesis of the Ga (III)-CS complex, followed by EPD from suitable solutions in an acetic acid–aqueous solvent. The influence of Ga (III) concentration on the stability of the suspensions was evaluated in terms of zeta potential. Fourier transform infrared (FTIR) and energy dispersive X-ray (EDX) spectroscopic analyses indicated the chelation of CS with Ga (III) within the coatings, while scanning electron microscopy (SEM) confirmed that no additional metallic gallium deposited during EPD. Furthermore, the results demonstrated that the wettability, mechanical properties, swelling ability, and enzymatic degradation of the coatings were affected by the quantity of Ga (III) ions. Colony forming unit (CFU) tests showed a strong synergistic effect between CS and Ga (III) in inhibiting Escherichia coli strain growth compared to control CS samples. An in vitro study with MG-63 cells showed that Ga (III)-containing coatings were not toxic after 24 h of incubation.

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Section: Antibacterial Assaymentioning

confidence: 99%

Electrophoretic Deposition and Characterization of Functional Coatings Based on an Antibacterial Gallium (III)-Chitosan Complex

et al. 2020

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“…Apart from intensive costs, this leads to high burdens for the patient as well as risks like amputation of the affected limb or even death in case of treatment failure [5,17]. So far, different prevention methods were studied avoiding bacterial adhesion in combination with enhancing osseointegration [18,19] like surface modifications or antimicrobial coatings of implants [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Biodistribution, biocompatibility and targeted accumulation of magnetic nanoporous silica nanoparticles as drug carrier in orthopedics

et al. 2020

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Background: In orthopedics, the treatment of implant-associated infections represents a high challenge. Especially, potent antibacterial effects at implant surfaces can only be achieved by the use of high doses of antibiotics, and still often fail. Drug-loaded magnetic nanoparticles are very promising for local selective therapy, enabling lower systemic antibiotic doses and reducing adverse side effects. The idea of the following study was the local accumulation of such nanoparticles by an externally applied magnetic field combined with a magnetizable implant. The examination of the biodistribution of the nanoparticles, their effective accumulation at the implant and possible adverse side effects were the focus. In a BALB/c mouse model (n = 50) ferritic steel 1.4521 and Ti90Al6V4 (control) implants were inserted subcutaneously at the hindlimbs. Afterwards, magnetic nanoporous silica nanoparticles (MNPSNPs), modified with rhodamine B isothiocyanate and polyethylene glycol-silane (PEG), were administered intravenously. Directly/1/7/21/42 day(s) after subsequent application of a magnetic field gradient produced by an electromagnet, the nanoparticle biodistribution was evaluated by smear samples, histology and multiphoton microscopy of organs. Additionally, a pathohistological examination was performed. Accumulation on and around implants was evaluated by droplet samples and histology.

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“…To the best of our knowledge, there are two ways to fabricate an anti-biofilm surface: depositing antibacterial coatings that release antimicrobial constituents or depositing antiadhesive coatings that restrict the adhesion of bacteria. Various antibiotics (e.g., lawsone, dexamethasone, minocycline, hinokitiol, tobramycin, gentamicin sulfate, and antimicrobial peptides) have been adopted to treat infections caused by implants (Ur Rehman et al, 2018;Zhang et al, 2018b;Deng et al, 2019;Xu et al, 2019;Yuan et al, 2019; Xue Tang et al, 2019Tang et al, et al, 2020Yin et al, 2020). Since the abuse of antibiotics has contributed to the emergence of bacterial resistance, several ions and their nanoparticles have emerged as promising alternatives to antibiotics (Figures 5A,B).…”

Section: Modifications Inspired By Bone Immune Functionmentioning

confidence: 99%

“…In addition, it has been reported that bacteria tend to adhere on implants with hydrophilic surfaces (Das et al, 2010). To prepare porous surfaces, sulfonation followed by hydrothermal treatment which can remove residues are applied (Ouyang et al, 2016;Yuan et al, 2019). Moreover, a porous surface can limit the adhesion of bacteria with different shapes and sizes.…”

Section: Modifications Inspired By Bone Immune Functionmentioning

confidence: 99%

Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering

Sun

et al. 2021

Front. Bioeng. Biotechnol.

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In recent years, polyetheretherketone (PEEK) has been increasingly employed as an implant material in clinical applications. Although PEEK is biocompatible, chemically stable, and radiolucent and has an elastic modulus similar to that of natural bone, it suffers from poor integration with surrounding bone tissue after implantation. To improve the bioactivity of PEEK, numerous strategies for functionalizing the PEEK surface and changing the PEEK structure have been proposed. Inspired by the components, structure, and function of bone tissue, this review discusses strategies to enhance the biocompatibility of PEEK implants and provides direction for fabricating multifunctional implants in the future.

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Multifunctional sulfonated polyetheretherketone coating with beta-defensin-14 for yielding durable and broad-spectrum antibacterial activity and osseointegration

Cited by 95 publications

References 51 publications

Electrophoretic Deposition and Characterization of Functional Coatings Based on an Antibacterial Gallium (III)-Chitosan Complex

Electrophoretic Deposition and Characterization of Functional Coatings Based on an Antibacterial Gallium (III)-Chitosan Complex

Biodistribution, biocompatibility and targeted accumulation of magnetic nanoporous silica nanoparticles as drug carrier in orthopedics

Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering

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