Multifunctional Spirogyra-hyalina-Mediated Barium Oxide Nanoparticles (BaONPs): Synthesis and Applications

Abstract

This research aims to biosynthesize Barium oxide nanoparticles (BaONPs) for biomedical applications, using Spirogyra hyalina as a stabilizing and reducing agent. UV–visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), energy-dispersive X-ray, X-ray diffraction (XRD), and scanning electron microscopy (SEM) were used to physiochemically characterize the barium oxide nanoparticles, while antibacterial, minimum inhibitory concentration, antifungal, free radicle scavenging, and anti-inflammatory assay were performed to assess the therapeutic potential of the synthesized BaONPs. Fourier transform infrared spectroscopy revealed bands at 615 and 692 cm−1 that corresponded to the formation of BaONPs. Scanning electron microscopy revealed the spherical and flower-shaped morphology of BaONPs having an average diameter of 64.01 ± 2.0 nm. Both Gram-positive and Gram-negative bacterial growth was halted by the barium nanoparticles, demonstrating their efficacy up to 19.12 ± 0.31 mm against E. coli, 18.83 ± 0.44 mm against Klebsiella pneumoniae, 17.31 ± 0.59 mm against P. aeruginosa, 16.56 ± 0.37 mm against S. aureus, and 15.75 ± 0.38 mm against S. epidermidis, respectively. The minimum inhibitory concentration was 9.0, 6.3, 5.5, 4.5, and 2.0 µg/mL for S. aureus, Klebsiella pneumoniae, S. epidermidis, P. aeruginosa, and E. coli, respectively. BaONPs were not that effective against fungal strains such as Rhizoctonia solani, Fusarium solani, and Fusarium proliferatum. The BaONPs exhibited potent anti-inflammatory and antioxidant activity through inhibiting cyclooxygenases type 1 (43.12 ± 1.21%) and 2 (41.23 ± 1.56%), and DPPH free radicles up to 43.52 ± 0.29% at 400 µg/mL. In conclusion, the biomolecules derived from Spirogyra hyalina have demonstrated remarkable ability to generate stable nanoparticles, offering promising prospects for their utilization as therapeutic agents and coating materials in various biomedical applications.

Size control of ropivacaine nano/micro-particles by soft-coating with peptide nanosheets for long-acting analgesia

“…Furthermore, strong negative surface charge brought by the terminal carboxyl group of the peptide also helped to enhance the dispersity of drug particles (Figure 3 and Figure 4 ). On the other hand, the self-assembling and encapsulation processes were completely carried out in water without involving in any toxic organic solvents, resembling the important advantage of environment-friendly green synthesis processes 45 , 46 . As a peptide material composed of natural amino acids, its biocompatibility has also been well-confirmed in both cell and animal experiments ( Figure S8 and S9).…”

Nanotechnology-Based Drug Delivery Systems for Honokiol: Enhancing Therapeutic Potential and Overcoming Limitations

“…Currently, numerous green synthesis methods have been reported, offering the potential to prepare safer and more effective nano-preparations. This avenue represents a promising direction for the [139][140][141][142][143] While there exists a variety of delivery systems for HNK, detailed characterizations of many nano-formulations, such as particle size, zeta potential, drug loading rates, and stability, often remain unexplored. Furthermore, some studies lack in-depth investigations into the in vivo effects of NDDSs, which are essential for verifying whether the outcomes align with those observed in vitro experiments.…”

Exploring Potential Applications of α and β Polymorphs of Bi2O3 Nanoparticles

“…Operating at room temperature is important to maintain the stability of plant metabolites. [39] But, in combustion synthesis treating the bismuth samples at higher temperature leads to the rapid depletion of bismuth ions and formation of homogeneous bismuth nuclei, resulting in the generation of small bismuth NPs. Mainly phenolic content of the jackfruit extract is involved in the reduction and stabilization of bismuth NPs synthesis.…”

“…Hence temperature plays a very important role during the synthesis of NPs. Operating at room temperature is important to maintain the stability of plant metabolites [39] . But, in combustion synthesis treating the bismuth samples at higher temperature leads to the rapid depletion of bismuth ions and formation of homogeneous bismuth nuclei, resulting in the generation of small bismuth NPs.…”