Multifunctional porous organic polymers (POPs): Inverse adsorption of hydrogen over nitrogen, stabilization of Pd(0) nanoparticles, and catalytic cross-coupling reactions and reductions

Yadav, Chetna; Maka, Vijay Kumar; Payra, Soumen; Moorthy, Jarugu Narasimha

doi:10.1016/j.jcat.2020.02.002

Cited by 33 publications

(17 citation statements)

References 64 publications

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“…Compounds 1d [57], 3 [45], 5b [58], 6 [59], 8a [60], 8d [46], 9a [60], 9b and 9c [61], 9d [59], 9g [62], 10 [59], 12a [63], 13a [64], and 17 [65] were synthesized, and the structure of these compounds has been confirmed by comparison with NMR spectral data from the literature.…”

Section: Compounds (Synthetic Coumarins)mentioning

confidence: 81%

Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial–Mesenchymal Transition and Migration in A549 Cells

et al. 2022

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A series of coumarin derivatives and isosteres were synthesized from the reaction of triflic intermediates with phenylboronic acids, terminal alkynes, and organozinc compounds through palladium-catalyzed cross-coupling reactions. The in vitro cytotoxic effect of the compounds was evaluated against two non-small cell lung carcinoma (NSCLC) cell lines (A-549 and H2170) and a normal cell line (NIH-3T3) using cisplatin as a reference drug. Additionally, the effects of the most promising coumarin derivative (9f) in reversing the epithelial-to-mesenchymal transition (EMT) in IL-1β-stimulated A549 cells and in inhibiting the EMT-associated migratory ability in A549 cells were also evaluated. 9f had the greatest cytotoxic effect (CC50 = 7.1 ± 0.8 and 3.3 ± 0.5 μM, respectively against A549 and H2170 cells) and CC50 value of 25.8 µM for NIH-3T3 cells. 9f inhibited the IL-1β-induced EMT in epithelial cells by inhibiting the F-actin reorganization, attenuating changes in the actin cytoskeleton reorganization, and downregulating vimentin in A549 cells stimulated by IL-1β. Treatment of A549 cells with 9f at 7 µM for 24 h significantly reduced the migration of IL-1β-stimulated cells, which is a phenomenon confirmed by qualitative assessment of the wound closure. Taken together, our findings suggest that coumarin derivatives, especially compound 9f, may become a promising candidate for lung cancer therapy, especially in lung cancer promoted by NSCLC cell lines.

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Section: Compounds (Synthetic Coumarins)mentioning

confidence: 81%

Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial–Mesenchymal Transition and Migration in A549 Cells

et al. 2022

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“…We herein demonstrated that HPS gives highly active catalysts at Pd concentrations of about 0.14–0.28 mol.%. At present, such a low Pd loading in the cross-coupling processes is of high importance and can be implemented using polymer-based catalysts [ 44 , 45 ]. The activity of the synthesized Pd/HPS catalysts is inferior to Pd supported on PAFs (porous aromatic frameworks) [ 4 ], but PAFs itself have a rather complex synthesis procedure.…”

Section: Discussionmentioning

confidence: 99%

Mono- and Bimetallic Nanoparticles Stabilized by an Aromatic Polymeric Network for a Suzuki Cross-Coupling Reaction

et al. 2021

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This work addresses the Suzuki cross-coupling between 4-bromoanisole (BrAn) and phenylboronic acid (PBA) in an environmentally benign ethanol–water solvent catalysed by mono- (Pd) and bimetallic (PdAu, PdCu, PdZn) nanoparticles (NPs) stabilised within hyper-cross-linked polystyrene (HPS) bearing tertiary amino groups. Small Pd NPs of about 2 nm in diameters were formed and stabilized by HPS independently in the presence of other metals. High catalytic activity and complete conversion of BrAn was attained at low Pd loading. Introduction of Zn to the catalyst composition resulted in the formation of Pd/Zn/ZnO NPs, which demonstrated nearly double activity as compared to Pd/HPS. Bimetallic core-shell PdAu/HPS samples were 3-fold more active as compared to Pd/HPS. Both Pd/HPS and PdAu/HPS samples revealed promising stability confirmed by catalyst recycling in repeated reaction runs.

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“…Large surface area, high stability, pore structure, and easy functionalization of POPs with catalytic sites turn them into superior candidates for catalytic applications. ,− Gold nanoparticles (AuNPs) own a greatly high surface area exhibiting considerable and unique size-dependent catalytic performance. Smaller AuNPs have higher surface energies and can aggregate to larger sizes, which leads to reduced catalytic activities. − To tackle this problem, AuNPs should be immobilized in porous materials.…”

Section: Different Applications Of Pops Prepared Via Friedel–crafts R...mentioning

confidence: 99%

Recent Applications of Porous Organic Polymers Prepared via Friedel–Crafts Reaction under the Catalysis of AlCl₃: A Review

Taheri

Dinari

Asgari

2022

ACS Appl. Polym. Mater.

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Since the development of porous materials, porous organic polymers (POPs) have received much attention due to advantages such as attractive architecture, large pore volume, high surface area, and immense porosity. Furthermore, their porous structure can be functionalized with multiple chemical reagents, which will improve their performances in various applications. In the past, significant efforts have been made to synthesize POPs via Friedel–Crafts reaction. It is easy to handle and operates under mild synthesis conditions, requires low reaction temperature, uses considerably less expensive chemicals, and produces high-yield POPs with desirable surface areas. POPs prepared via this method act competitively in various fields. This review focuses on the recent applications of the POPs introduced in gas adsorption and separation, catalyst, water treatment, biomedical, and electrochemical applications, aiming to pave the way for researchers to develop new POPs for modern applications.

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Multifunctional porous organic polymers (POPs): Inverse adsorption of hydrogen over nitrogen, stabilization of Pd(0) nanoparticles, and catalytic cross-coupling reactions and reductions

Cited by 33 publications

References 64 publications

Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial–Mesenchymal Transition and Migration in A549 Cells

Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial–Mesenchymal Transition and Migration in A549 Cells

Mono- and Bimetallic Nanoparticles Stabilized by an Aromatic Polymeric Network for a Suzuki Cross-Coupling Reaction

Recent Applications of Porous Organic Polymers Prepared via Friedel–Crafts Reaction under the Catalysis of AlCl₃: A Review

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Multifunctional porous organic polymers (POPs): Inverse adsorption of hydrogen over nitrogen, stabilization of Pd(0) nanoparticles, and catalytic cross-coupling reactions and reductions

Cited by 33 publications

References 64 publications

Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial–Mesenchymal Transition and Migration in A549 Cells

Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial–Mesenchymal Transition and Migration in A549 Cells

Mono- and Bimetallic Nanoparticles Stabilized by an Aromatic Polymeric Network for a Suzuki Cross-Coupling Reaction

Recent Applications of Porous Organic Polymers Prepared via Friedel–Crafts Reaction under the Catalysis of AlCl3: A Review

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Recent Applications of Porous Organic Polymers Prepared via Friedel–Crafts Reaction under the Catalysis of AlCl₃: A Review