Multifunctional Polyampholyte Hydrogels with Fouling Resistance and Protein Conjugation Capacity

Schroeder, Megan E.; Zurick, Kevin M.; McGrath, Daniel E; Bernards, Matthew T.

doi:10.1021/bm4007369

Cited by 63 publications

(76 citation statements)

References 44 publications

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“…Polyampholyte hydrogels, synthesized through the copolymerization of oppositely charged monomers at high concentration, have captured wide attention due to their tunable properties and a variety of functions, such as self‐healing, self‐adjustable adhesion, and shape memory. [3a,15] They have been used in the fields of controlled drug delivery and tissue regeneration scaffold . Nevertheless, when the polyampholyte hydrogels are used for the shape memory, the common shortcoming is still that the original shape cannot change to the temporary shape without external force.…”

Section: Introductionmentioning

confidence: 99%

Polyampholyte Hydrogels with pH Modulated Shape Memory and Spontaneous Actuation

Zhang

Liao

Wang

et al. 2018

Adv Funct Materials

152

128

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Polyampholyte hydrogels are synthesized by one-step copolymerization of cationic monomer 3-(methacryloylamino)propyltrimethylammonium chloride, anionic monomers sodium p-styrenesulfonate (NaSS), and methacrylic acid (MAA) without chemical crosslinker and adding salts. The hydrogels exhibit pH responsive shape memory behavior; the temporary shape of the hydrogel is formed manually after immersing in NaOH solution and fixed in HCl solution, while the shape recovery occurs by immersing in NaOH again. Most interestingly, the hydrogel shows a spontaneous shape change after the first shape memory cycle. When the recovered hydrogel with a little residual deformation is immersed in HCl again, it twists spontaneously and rapidly to the previous temporary shape. The spontaneous twisting and recovering can be repeated for ten times. Furthermore, the hydrogel swells quickly and is strengthened in HCl, while shrinks and weakens in NaOH during the shape change procedure. This unique synergistic effect of fast swelling, residual helical deformation, and increased strength plays a significant role in the spontaneous shape alternation. This new finding will initiate a new prosperous design for new soft actuators requiring successive actions.

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Section: Introductionmentioning

confidence: 99%

Polyampholyte Hydrogels with pH Modulated Shape Memory and Spontaneous Actuation

Zhang

Liao

Wang

et al. 2018

Adv Funct Materials

152

128

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“…13 or by co-polymerizing anionic and cationic monomers. 15 We have approached this issue in a slightly different way; since these materials are ampholytic, the net charge will depend on the pH, and to investigate pH effects we have prepared layered polymer gradients, where a homogeneous layer of a charged polymer is covered by a gradient thickness layer of an oppositely charged polymer. The two polymer layers will interpenetrate, and at some thickness of the upper layer, they will form a charge-neutral region.…”

Section: Introductionmentioning

confidence: 99%

pH-control of the protein resistance of thin hydrogel gradient films

et al. 2014

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We report on the preparation and characterization of thin polyampholytic hydrogel gradient films permitting pH-controlled protein resistance via the regulation of surface charges. The hydrogel gradients are composed of cationic poly(2-aminoethyl methacrylate hydrochloride) (PAEMA), and anionic poly(2-carboxyethyl acrylate) (PCEA) layers, which are fabricated by Self-Initiated Photografting and Photopolymerization (SIPGP). Using a two-step UV exposure procedure, a polymer thickness gradient of one component is formed on top of a uniform layer of the oppositely charged polymer. The swelling of the gradient films in water and buffers at different pH were characterized by imaging spectroscopic ellipsometry. The surface charge distribution and steric interactions with the hydrogel gradients were recorded by direct force measurement with colloidal-probe atomic force microscopy. We demonstrate that formation of a charged polymer thickness gradient on top of a uniform layer of opposite charge can result in a region of charge-neutrality. This charge-neutral region is highly resistant to non-specific adsorption of proteins, and its location along the gradient can be controlled via the pH of the surrounding buffer. The pH-controlled protein adsorption and desorption was monitored in real-time by imaging surface plasmon resonance, while the corresponding redistribution of surface charge was confirmed by direct force measurements.

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“…Pseudo-zwitterionic materials (or mixed charged polymers), as newer classes of biomedical surface modifiers, are enhanced semi-ZW structures with positively dual charged structures that are not affected by other chemical functional groups due to higher stability. Accordingly, they have been introduced as better candidates for improving hemodialysis membranes by surface immobilization or forming hydrogels [68][69][70]. Table 1 offers some of the most recent efforts focused on zwitterionization of membrane surfaces.…”

Section: Hemocompatibility Enhancementsmentioning

confidence: 99%

Challenges and Advances in Hemodialysis Membranes

Mollahosseini¹,

Abdelrasoul²,

Shoker³

2020

Advances in Membrane Technologies

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Hemodialysis (HD) is a filtration vital process through which the bloods' toxins and contaminations are removed. However, several immune system activations occur during dialysis, which can result in morbidity and mortality. The efficiency of the currently available blood purification process is hindered, on one hand, by the deficient toxins and middle molecule removal, and on the other hand, with the loss of valuable blood components (such as plasma and its constituents). This chapter offers an overview of the challenges and advances in HD membranes. It includes an introduction of the end stage renal disease, concepts of dialysis, its historical background, and the path through which the configurations and materials evolved. The interactions between membrane polymeric materials with human blood is also discussed. The aspect of material modification is one of the critical areas in HD technology as it targets to solve the most immediate and prevalent HD issue of membrane bioincompatibility. High flux dialysis (HFD) and hemofiltration (HF) are introduced and discussed. This class of membranes was introduced to solve middle molecule (such as β2-microglobulin) related challenges. This chapter highlights the question of why the issue of incompatible materials still exists along with current membrane modifications.

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Multifunctional Polyampholyte Hydrogels with Fouling Resistance and Protein Conjugation Capacity

Cited by 63 publications

References 44 publications

Polyampholyte Hydrogels with pH Modulated Shape Memory and Spontaneous Actuation

Polyampholyte Hydrogels with pH Modulated Shape Memory and Spontaneous Actuation

pH-control of the protein resistance of thin hydrogel gradient films

Challenges and Advances in Hemodialysis Membranes

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