Multifunctional pH-Disintegrable micellar nanoparticles of asymmetrically functionalized β-cyclodextrin-Based star copolymer covalently conjugated with doxorubicin and DOTA-Gd moieties

Liu, Tao; Li, Xiaojie; Qian, Yinfeng; Hu, Xianglong; Liu, Shiyong

doi:10.1016/j.biomaterials.2011.12.013

Cited by 159 publications

(98 citation statements)

References 54 publications

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“…The r 1 value of Gd@SiO 2 -DOX/ICG-PDC was much greater than that of Gd-DTPA (r 1 =3.50 mM −1 s −1 ), 42 one of the commonly used commercial MRI T 1 -contrast agent. [43][44][45][46] The reason is that Gd (III) can be bound to citrate to produce Gd(III) core (as shown in Table 1 and Figure 2), which restricts the local motions of Gd. Additionally, the r 2 /r 1 ratio is so low that is beneficial for high signal-to-noise ratio imaging.…”

Section: Ratio Of Gadolinium Species In the Samplesmentioning

confidence: 97%

Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging

Cao

Wang

Kou

et al. 2015

ACS Appl. Mater. Interfaces

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The combination of therapy and diagnosis has been emerging as a promising strategy for cancer treatment. To realize chemotherapy, photothermal therapy, and magnetic resonance imaging (MRI) in one system, we have synthesized a new magnetic nanoparticle (Gd@SiO2-DOX/ICG-PDC) integrating doxorubicin (DOX), indocyanine green (ICG), and gadolinium(III)-chelated silica nanospheres (Gd@SiO2) with a poly(diallyldimethylammonium chloride) (PDC) coating. PDC coating serves as a polymer layer to protect from quick release of drugs from the nanocarriers and increase cellular uptake. The DOX release from Gd@SiO2-DOX/ICG-PDC depends on pH and temperature. The process will be accelerated in the acidic condition than in a neutral pH 7.4. Meanwhile, upon laser irradiation, the photothermal effects promote DOX release and improve the therapeutic efficacy compared to either DOX-loaded Gd@SiO2 or ICG-loaded Gd@SiO2. Moreover, MRI results show that the Gd@SiO2-PDC nanoparticles are safe T1-type MRI contrast agents for imaging. The Gd@SiO2-PDC nanoparticles loaded with DOX and ICG can thus act as a promising theranostic platform for multimodal cancer treatment.

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Section: Ratio Of Gadolinium Species In the Samplesmentioning

confidence: 97%

Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging

Cao

Wang

Kou

et al. 2015

ACS Appl. Mater. Interfaces

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show abstract

“…When structural stability of the micelles is affected, the drug burst release is inevitable during blood circulation, leading to undesirable toxicity and a low therapeutic index. [23][24][25] To solve the above-mentioned stability issue of polymeric micelles, shell or core cross-linked micelles have been proposed. After micelles cross-linking, they are found to be stable against disassociation under high dilution, and their aggregation is independent of external influences such as changes in pH values and other interference.…”

Section: Introductionmentioning

confidence: 99%

Platinum covalent shell cross-linked micelles designed to deliver doxorubicin for synergistic combination cancer therapy

Zhu¹,

Xiao²,

Tang³

et al. 2017

IJN

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The preparation of polymer therapeutics capable of controlled release of multiple chemotherapeutic drugs has remained a tough problem in synergistic combination cancer therapy. Herein, a novel dual-drug co-delivery system carrying doxorubicin (DOX) and platinum(IV) (Pt[IV]) was developed. An amphiphilic diblock copolymer, PCL-b-P(OEGMA-co-AzPMA), was synthesized and used as a nanoscale drug carrier in which DOX and Pt(IV) could be packaged together. The copolymers were shell cross-linked by Pt(IV) prodrug via a click reaction. Studies on the in vitro drug release and cellular uptake of the dual-drug co-delivery system showed that the micelles were effectively taken up by the cells and simultaneously released drugs in the cells. Futhermore, the co-delivery polymer nanoparticles caused much higher cell death in HeLa and A357 tumor cells than either the free drugs or single-drug-loaded micelles at the same dosage, exhibiting a synergistic combination of DOX and Pt(IV). The results obtained with the shell cross-linked micelles based on an anticancer drug used as a cross-linking linkage suggested a promising application of the micelles for multidrug delivery in combination cancer therapy.

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“…In this context, star polymerbased macromolecular MRI contrast agents have been prepared by conjugating small-molecule contrast agents to star polymer structures derived from hyperbranched H40 polyester, b-CD, and tetraphenylethylene cores. [44][45][46][47] These star-shaped macromolecular contrast agents have substantial benefits in terms of stability, enhanced circulation time, increased relaxivity, and potential for functional modification.…”

Section: Star Polymers For Imaging and Theranostic Applicationsmentioning

confidence: 99%

Synthesis of Star Polymers by RAFT Polymerization as Versatile Nanoparticles for Biomedical Applications

Qiao

Whittaker

et al. 2017

Aust. J. Chem.

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The precise control of polymer chain architecture has been made possible by developments in polymer synthesis and conjugation chemistry. In particular, the synthesis of polymers in which at least three linear polymeric chains (or arms) are tethered to a central core has yielded a useful category of branched architecture, so-called star polymers. Fabrication of star polymers has traditionally been achieved using either a core-first technique or an arm-first approach. Recently, the ability to couple polymeric chain precursors onto a functionalized core via highly efficient coupling chemistry has provided a powerful new methodology for star synthesis. Star syntheses can be implemented using any of the living polymerization techniques using ionic or living radical intermediates. Consequently, there are innumerable routes to fabricate star polymers with varying chemical composition and arm numbers. In comparison with their linear counterparts, star polymers have unique characteristics such as low viscosity in solution, prolonged blood circulation, and high accumulation in tumour regions. These advantages mean that, far beyond their traditional application as rheology control agents, star polymers may also be useful in the medical and pharmaceutical sciences. In this account, we discuss recent advances made in our laboratory focused on star polymer research ranging from improvements in synthesis through to novel applications of the product materials. Specifically, we examine the core-first and arm-first preparation of stars using reversible addition-fragmentation chain transfer (RAFT) polymerization. Further, we also discuss several biomedical applications of the resulting star polymers, particularly those made by the arm-first protocol. Emphasis is given to applications in the emerging area of nanomedicine, in particular to the use of star polymers for controlled delivery of chemotherapeutic agents, protein inhibitors, signalling molecules, and siRNA. Finally, we examine possible future developments for the technology and suggest the further work required to enable clinical applications of these interesting materials.

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Multifunctional pH-Disintegrable micellar nanoparticles of asymmetrically functionalized β-cyclodextrin-Based star copolymer covalently conjugated with doxorubicin and DOTA-Gd moieties

Cited by 159 publications

References 54 publications

Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging

Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging

Platinum covalent shell cross-linked micelles designed to deliver doxorubicin for synergistic combination cancer therapy

Synthesis of Star Polymers by RAFT Polymerization as Versatile Nanoparticles for Biomedical Applications

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