Multifunctional Oxidized Succinoglycan/Poly(N-isopropylacrylamide-co-acrylamide) Hydrogels for Drug Delivery

Hu, Yan‐Yan; Shin, Younghyun; Park, Sohyun; Jeong, Jaepil; Kim, Young S.; Jung, Seunho

doi:10.3390/polym15010122

Cited by 8 publications

(4 citation statements)

References 61 publications

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“…It was also confirmed that the final remaining weight percentages of the samples were calculated to be about 21% (SG), 6% (PVA/SG 50/50 hydrogel), and 2% (PVA). These results corresponded with previous reports that the thermal stability of hydrogels was enhanced after incorporating SG [ 51 ].…”

Section: Resultssupporting

confidence: 93%

New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug Delivery

Jeong

Kim

et al. 2023

Polymers

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We fabricated new hydrogels using polyvinyl alcohol (PVA) and succinoglycan (SG) directly isolated and obtained from Sinorhizobium meliloti Rm 1021 via the freeze–thaw method. Both the composition of the hydrogels and the freeze–thaw cycles were optimized to maximize the swelling ratio for the preparation of the PVA/SG hydrogels. During the optimization process, the morphology and conformational change in the hydrogel were analyzed by scanning electron microscopy, rheological measurements, and compressive tests. An optimized hydrogel with a maximum swelling ratio of 17.28 g/g was obtained when the composition of PVA to SG was 50:50 (PVA/SG 50/50) and the total number of freeze–thaw cycles was five. The PVA/SG 50/50 hydrogel had the largest pore with 51.24% porosity and the highest cross-over point (28.17%) between the storage modulus (G′) and the loss modulus (G″). The PVA/SG 50/50 hydrogel showed improved thermal stability owing to its interaction with thermally stable SG chains. The improvement in the thermal stability was confirmed by thermogravimetric analysis and differential scanning calorimetry. In addition, the PVA/SG 50/50 hydrogel showed differential drug release according to the corresponding pH under acidic conditions of pH 1.2 and slightly basic conditions of pH 7.4. Furthermore, the cell viability test on the HEK-293 cell line for that hydrogel demonstrated that the PVA/SG 50/50 hydrogel was non-toxic and biocompatible. Therefore, this hydrogel could be a potential scaffold capable of pH-responsive drug delivery for chronic wound dressing applications.

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Section: Resultssupporting

confidence: 93%

New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug Delivery

Jeong

Kim

et al. 2023

Polymers

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“…In the XRD pattern of IPN gel, it can be seen that the gel has a secondary peak at 2θ = 8.2° and a broad peak near 2θ = 21°, which indicates that there are both KGM gel components and the composition of NIPAM gel. Moreover, it was found that IPN gel had some sharp peaks at 2θ = 31.9° and 2θ = 45.7°, indicating that NIPAM crystals were produced [ 34 ]. This indicated that KGM interacted with NIPAM in the preparation of IPN hydrogel.…”

Section: Resultsmentioning

confidence: 99%

Preparation and Application of Double Network Interpenetrating Colon Targeting Hydrogel Based on Konjac Glucomannan and N-Isopropylacrylamide

Yao

Deng³

et al. 2023

Gels

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Konjac glucomannan (KGM) can be degraded by colon-specific enzymes in the colonic environment, making it one of the materials for treating colonic diseases, which has attracted more and more attention. However, during drug administration, especially in the gastric environment and due to its easy swelling, the structure of KGM is usually destroyed and the drug is released, thereby reducing the bioavailability of the drug. To solve this problem, the easy swelling and drug release properties of KGM hydrogels are avoided by creating interpenetrating polymer network hydrogels. In this study, N-isopropylacrylamide (NIPAM) is first formed into a hydrogel framework under the action of a cross-linking agent to stabilize the gel shape before the gel is heated under alkaline conditions to make KGM molecules wrap around the NIPAM framework. The structure of the IPN(KGM/NIPAM) gel was confirmed using Fourier transform infrared spectroscopy (FT-IR) and x-ray diffractometer (XRD). In the stomach and small intestine, it was found that the release rate and swelling rate of the gel were 30% and 100%, which were lower than 60% and 180% of KGM gel. The experimental results showed that this double network hydrogel has a good colon-directed release profile and fine drug carrier ability. This provides a new idea for the development of konjac glucomannan colon-targeting hydrogel.

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“…Its characteristic peaks appeared at 2θ = 11.4°, 19.6°, 22.8°, and 40.9°, indicating the inherent patterns of the PVA crystalline structure [47,48]. The peak around 19.5° of SG, which had a broad pattern compared with PVA, revealed the structural amorphous nature of SG [49]. From the crystal pattern of the fabricated PVA film, it could be observed that the characteristic crystalline peak became weak.…”

Section: Xrd Analysismentioning

confidence: 97%

Structural and Physiochemical Properties of Polyvinyl Alcohol–Succinoglycan Biodegradable Films

Jeong,

Yoon,

Kim

et al. 2024

Polymers

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Polyvinyl alcohol (PVA)–bacterial succinoglycan (SG) biodegradable films were developed through a solvent-casting method. Effects of the PVA/SG ratio on the thickness, transmittance, water holding capacity, and structural and mechanical properties were investigated by various analytical methods. All the prepared films were transparent and uniform, and XRD and FTIR analyses confirmed that PVA was successfully incorporated into SG. The films also showed excellent UV-blocking ability: up to close to 80% with increasing SG concentration. The formation of effective intermolecular interactions between these polymers was evidenced by their high tensile strength and moisture transport capacity. By measuring the biodegradation rate, it was confirmed that films with high SG content showed the fastest biodegradation rate over 5 days. These results confirm that PVA/SG films are eco-friendly, with both excellent biodegradability and effective UV-blocking ability, suggesting the possibility of industrial applications as a packaging material in various fields in the future.

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Multifunctional Oxidized Succinoglycan/Poly(N-isopropylacrylamide-co-acrylamide) Hydrogels for Drug Delivery

Cited by 8 publications

References 61 publications

New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug Delivery

New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug Delivery

Preparation and Application of Double Network Interpenetrating Colon Targeting Hydrogel Based on Konjac Glucomannan and N-Isopropylacrylamide

Structural and Physiochemical Properties of Polyvinyl Alcohol–Succinoglycan Biodegradable Films

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