Multifunctional neuron-specific enolase: its role in lung diseases

Xu, Caiming; Luo, Yalan; Li, Shuai; Li, Zhaoxia; Liu, Jiang; Zhang, Guixin; Owusu, Lawrence; Chen, Hailong

doi:10.1042/bsr20192732

Cited by 64 publications

(56 citation statements)

References 121 publications

(131 reference statements)

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“…Since the performance of lung cancer biomarkers is still debatable in clinical practice, their use for lung cancer diagnosis, therapeutic monitoring, and prognosis prediction is ambiguous, of which is partly because of lacking a rigorous standardized reference interval. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] A reliable reference interval is therefore critical for the performance evaluation of a biomarker. Apart from following the requirements of CLSI EP28-A3C guidelines, this study also considered geography to explore whether physical location influenced outcomes when establishing a reference interval for biomarkers.…”

Section: Discussionmentioning

confidence: 99%

“…There is thus an urgent need to improve lung cancer risk assessments because current in vitro diagnosis-based screening criteria miss a large number of cases. 15 Although there are plenty of reports regarding lung cancer biomarkers and their diagnostic performance available thus far, [16][17][18][19][20][21][22][23] a well-established reference interval for each lung cancer biomarker is still desired to enhance the performance of the aforementioned biomarkers. To establish a well-designed and dependable reference interval, certain criteria of the study subjects-such as age, gender, geographic location, and life style-should be considered, because they may have an impact on the levels of biomarkers of individuals to be investigated.…”

Section: Introductionmentioning

confidence: 99%

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Age‐stratified and gender‐specific reference intervals of six tumor markers panel of lung cancer: A geographic‐based multicenter study in China

Zhang

et al. 2021

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Age‐stratified and gender‐specific reference intervals of six tumor markers panel of lung cancer: A geographic‐based multicenter study in China

Zhang

et al. 2021

Clinical Laboratory Analysis

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“…Neuron-specific enolase (NSE) is a glycolytic enzyme that is localized in the cytoplasm of neurons and neuroendocrine cells. It is found primarily in the amine precursor uptake and decarboxylation (APUD) lineage, such as in the pituitary, thyroid, pancreas, intestine, and lung [ 2 ]. NSE is used as a tumor marker in the diagnosis, prognosis, and follow-up of small cell lung cancer (SCLC), and its serum levels differ significantly according to tumor size, disease stage, and metastasis [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Neuron-specific enolase serum levels in COVID-19 are related to the severity of lung injury

et al. 2021

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The multifunctional role of neuron-specific enolase (NSE) in lung diseases is well established. As the lungs are greatly affected in COVID-19, we evaluated serum NSE levels in COVID-19 patients with and without dyspnea. In this study, we evaluated both SARS-CoV-2-infected and uninfected patients aged >18 years who were referred to hospitals in Catanzaro, Italy from March 30 to July 30, 2020. Epidemiological, clinical, and radiological characteristics, treatment, and outcome data were recorded and reviewed by a trained team of physicians. In total, 323 patients (178 men, 55.1% and 145 women, 44.9%) were enrolled; of these, 128 were COVID-19 patients (39.6%) and 195 were control patients (60.4%). Westergren’s method was used to determine erythroid sedimentation rate. A chemiluminescence assay was used for measurement of interleukin-6, procalcitonin, C-reactive protein, and NSE. We detected significantly higher NSE values (P<0.05) in COVID-19 patients than in controls. Interestingly, within the COVID-19 group, we also observed a further significant increase in dyspnea (Dyspnea Scale and Exercise score: 8.2 ± 0.8; scores ranging from 0 to 10, with higher numbers indicating very severe shortness of breath). These data provide the background for further investigations into the potential role of NSE as a clinical marker of COVID-19 progression.

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“…However, glial cells and astrocytes are also shown to express both homo and heterodimeric forms of the enzyme [60]. γ-enolase is also known to be in cells of the amine precursor uptake and decarboxylation lineage [63,64,66].…”

Section: Neuron Specifi C Enolase and Pdmentioning

confidence: 99%

Role of neuron specific enolase as a biomarker in Parkinson’s disease

Dutta¹

2021

J Neurosci Neurol Disord

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Parkinson’s disease (PD) is thought to be the most common neurodegenerative disease with movement disorder. The key motor symptoms are rigidity, tremor, akinesis/hypokinesia/bradykinesia, and postural instability. However, in our day-to-day clinical practice we tend to see several other symptoms which may be motor or non-motor. Non-motor symptoms (NMS) are quite common and debilitating. The pathological hallmarks of PD are loss of dopaminergic neurons in the substantia nigra pars compacta (SNPc) and accumulation of unfolded or misfolded alpha-synuclein. Diagnosis of PD is difficult in the pre-motor stage. Late diagnosis renders a substantial loss of dopaminergic neurons in SNPc and spread of disease in other parts of the brain. This may manifest as either full blown symptoms requiring multiple medications or may even lead to life threatening condition due to lack of early diagnostic tools and techniques. Biomarkers are required to diagnose PD at a very early stage when prevention is possible. Hence, we see a lot of interest among researchers involved in finding a biomarker specific to the disease. Biomarkers may be clinical, image based, genetic, and biochemical. Cerebrospinal fluid (CSF) and serum markers which may correlate with disease pathophysiology are of great significance. One such molecule which recently gained a lot of attention is neuron-specific enolase (NSE). The main aim of this paper is to highlight the role of NSE in predicting neurodegeneration and neuroinflammation ultimately reflecting damage of brain cells in PD.

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Multifunctional neuron-specific enolase: its role in lung diseases

Cited by 64 publications

References 121 publications

Age‐stratified and gender‐specific reference intervals of six tumor markers panel of lung cancer: A geographic‐based multicenter study in China

Age‐stratified and gender‐specific reference intervals of six tumor markers panel of lung cancer: A geographic‐based multicenter study in China

Neuron-specific enolase serum levels in COVID-19 are related to the severity of lung injury

Role of neuron specific enolase as a biomarker in Parkinson’s disease

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