Multifunctional NaYF₄:Nd/NaDyF₄ nanocrystals as a multimodal platform for NIR-II fluorescence and magnetic resonance imaging

Abstract

Recently, multimodal imaging nanoprobes based on the complementary advantages of various imaging methods have attracted considerable attention due to their potential application in the biomedical field.

Core–multi-shell design: unlocking multimodal capabilities in lanthanide-based nanoparticles as upconverting, T2-weighted MRI and CT probes

“…Noteworthy, all the r 2 values of Cit-Dy-CSS NPs are higher than those of commercial iron oxide-based T 2 contrast agents (Combidex: 60.0 mM −1 s −1 , Feridex: 93.0 mM −1 s −1 ) and other comparable sized Dy-based NPs (Table S2†). 5,10,26,27,35,47–54 These observations are promising with respect to the potential use of Dy-CSS NPs T 2 CAs. Particularly, high relaxivity CAs are generally considered beneficial as they can allow for the administration of lower doses, ultimately contributing to lower toxicity risks.…”

“…[20][21][22][23] On the other hand, clinically used MRI T 2 CAs are based on iron oxides, which, however, suffer from magnetization saturation at high magnetic fields (greater than 3 T). 24 Dy 3+ is a suitable candidate for high-field T 2 CAs due to its relatively large magnetic moment (10.6µ B ) and short relaxation time, without saturation of the magnetization even at high magnetic fields up to 11.7 T. [25][26][27][28] High-field MRI is gaining increasing attention due to its higher spatial resolution and signal-to-noise ratio, holding potential for more effective diagnostic imaging. 28,29 Therewith comes the raising demand for suitable high-field T 2 CAs.…”

Nanotherapy to Reshape the Tumor Microenvironment: A New Strategy for Prostate Cancer Treatment

“…These properties make them suitable for applications in biological imaging, such as fluorescence imaging, bioimaging, and molecular imaging. By incorporating lanthanide-doped nanocrystals into contrast agents, researchers can improve the sensitivity and resolution of imaging techniques such as magnetic resonance imaging (MRI) and optical imaging . Lanthanide-doped nanocrystals can also be used for therapeutic purposes.…”

Tracking tumor heterogeneity and progression with near‐infrared II fluorophores

“…visualize the progression of tumors. [227] Multimodal imaging, including CT, US, MRI, and NIR-II, improved the accuracy of tumor staging by integrating different imaging modes into a hybrid system. [132,[228][229][230][231][232][233] NIR-II PA tomography imaging showed that BTII-DUPA can target actively the prostate-specific membrane antigen-positive prostate tumors in vivo.…”