Multifunctional Nanoplatform Based on Black Phosphorus Quantum Dots for Bioimaging and Photodynamic/Photothermal Synergistic Cancer Therapy

Li, Yang; Liu, Zhiming; Hou, Yuqing; Yang, Guangcun; Fei, Xixi; Zhao, Henan; Guo, Yanxian; Su, Chengkang; Wang, Zhen; Zhong, Huiqing; Zhuang, Zhengfei; Guo, Zhouyi

doi:10.1021/acsami.7b05824

Cited by 193 publications

(128 citation statements)

References 46 publications

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“…BP is an ideal theranostic agent due to its inherent PA characteristics for imaging and the ability to load various fluorescent substances for both in vitro and in vivo imaging, as well as PTT and PDT characteristics for therapy. Li et al established a PEGylated BPQDs based multifunctional nanoplatform for cancer bioimaging and combined PTT with PDT. Fluorescent molecules were loaded onto BPQD, and fluorescence imaging of cancer cells was accomplished.…”

Section: Biomedical Applications Of Bpmentioning

confidence: 99%

2D Black Phosphorus–Based Biomedical Applications

Luo

Fan

Zhou

et al. 2019

Adv Funct Materials

462

306

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Black phosphorus (BP) has increasingly attracted scientific attention since its first applications in biomedicine due to its unique properties and excellent biocompatibility. In particular, its layer-dependent bandgap, moderate carrier mobility, large surface-area-to-volume ratio, biodegradability, intrinsic photoacoustic properties, and biocompatibility make it an ideal candidate for use in photothermal therapy, photodynamic therapy, drug delivery, 3D printing, bioimaging, biosensing, and theranostics, which are reviewed here. In addition, the article discusses strategies to overcome challenges related to surface instability due to chemical degradation, a major obstacle for its application. This review not only provides a comprehensive summary on BP preparation and biomedical applications but also summarizes recent research and future possibilities.

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Section: Biomedical Applications Of Bpmentioning

confidence: 99%

2D Black Phosphorus–Based Biomedical Applications

Luo

Fan

Zhou

et al. 2019

Adv Funct Materials

462

306

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“…PEGylated BPQDs acted as nanocarriers for loading organic fluorescent dyes, RhB. The formed fluorescence probes, RhB/PEG‐BPQDs, were distinctly located in the cytoplasm for FL imaging of Hep G2 cells and 4T1 cells . Fluorescence cyanine7‐loading BP nanoparticles achieved the desirable in vivo NIR FL imaging toward 4T1 tumor‐bearing mice …”

Section: Biomedical Application Of Nano‐bpmentioning

confidence: 99%

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

Xia

Guo

2019

Adv Funct Materials

182

115

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Black phosphorus nanostructures (nano-BPs) include BP nanosheets, BP quantum dots, and BP nanoparticles. Since first being discovered in 2014, nano-BP has become one of the most popular nanomaterials. Nano-BP has many unique properties, such as excellent surface activity, tunable bandgap, high carrier mobility, moderate on/off ratio, excellent biocompatibility, good biodegradation, etc., all of which make nano-BP particularly attractive in biomedicine and biosensing. This review article comprehensively summarizes recent advances in synthesis, functionalization, biomedicine, and biosensing applications of nano-BP. Different methods are first introduced, such as mechanical cleavage, liquid-phase ultrasonic exfoliation, electrochemical exfoliation, solvothermal treatment, and acoustic-microfluidic stripping, for making the nano-BP. Then two strategies are emphasized to enhance ambient stability of nano-BP, namely physical encapsulation and chemical modification. Next, how to develop nano-BP as advanced imaging agents, nanocarriers, and nanomedicine for bioimaging (fluorescence imaging, thermal imaging, and photoacoustic imaging) and disease treatment (phototherapy and photo/chemical/immune synergistic therapy) is demonstrated. The biosensing applications on nano-BP is introduced, including electrochemical biosensor, fluorescence biosensor, chemiluminescence biosensor, electrogenerated chemiluminescence biosensor, and colorimetric biosensor. Finally, the current challenges and future perspectives on nano-BP in bioapplications are discussed. Nano-BP SynthesisLayered nanomaterials are usually exfoliated from bulk crystals. [35] Compared with bulk materials, monolayer or fewlayer nanomaterials possess the enhanced surface area, excellent physiochemical activity and optoelectronic property. The exfoliation from bulk crystal to monolayer or few-layer nanosheets has been widely applied for preparing almost all the 2D nanomaterials, graphene, MoS 2 , MXene nanosheets, etc. [36] Bulk BP, similar to graphite, is the stacking of layered BP nanosheets via the weak van der Waals force. The destruction of the external driving forces to the weak van der Waals interaction between the stack layers greatly contributes to the exfoliation of nano-BP from the bulk counterparts. Mechanical exfoliation and liquid phase ultrasonic exfoliation are the two most popular approaches, and some other methods were also involved, electrochemical exfoliation and solvothermal treatment, for instance. Table 1 summarizes the advantages and limitations of different exfoliation methods. Mechanical ExfoliationMechanical exfoliation, also called scotch-tape delamination, mainly utilizes the larger binding energy between the substrate and layered materials than van der Waals forces in Figure 2. a) Schematic illustration of meta-assisted mechanical exfoliation for FLBP. b) The left is FLBPs exfoliated using the normal scotch-tape microcleavage, and the right is FLBP exfoliated using Au-assisted method, and c) the total area of FLBP on 10 different samples. ...

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“…Among various nanoparticles, gold nanoparticles are the most widely used in the biomedical field because of their advantageous properties such as biocompatibility and facile modification [96][97][98][99][100][101][102]. According to their size, shape, and structure, they also have controllable surface plasmon resonance (SPR).…”

Section: Optical Imaging In Drug Delivery (Theranostics)mentioning

confidence: 99%

Recent Advances in Bioimaging for Cancer Research

Lim¹,

Son²,

Lim³

2018

State of the Art in Nano-Bioimaging

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Molecular imaging techniques as well as nanoparticle applicable to molecular imaging are being explored to improve the cancer detection accuracy, which help to manage efficiently at the early stage. Among the various imaging technologies, optical imaging is a highly sensitive detection technique that allows direct observation of specific molecular events, biological pathways, and disease processes in real time through imaging probes that emit light in a range of wavelengths. Recently, nanoparticles have provided significant progresses that can be simultaneously used for cancer diagnosis and therapy (cancer theranostics). Theranostics aims to provide "image-guided cancer therapy," by integrating therapeutic and imaging agents in a single platform. In addition, molecular imaging techniques facilitate "image-guided surgery" enabling maximization of tumor excision and minimization of side effects. The optical signals generated by fluorescence nanoparticles offer the possibility to distinguish tumor sites and normal tissues during surgery by real-time guidance, thereby increasing the long-term patient survival. These techniques will considerably contribute to reducing cancer recurrence and developing more effective cures. In this chapter, we will introduce diverse research on nanomaterials-based optical imaging for effective cancer therapy.

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Multifunctional Nanoplatform Based on Black Phosphorus Quantum Dots for Bioimaging and Photodynamic/Photothermal Synergistic Cancer Therapy

Cited by 193 publications

References 46 publications

2D Black Phosphorus–Based Biomedical Applications

2D Black Phosphorus–Based Biomedical Applications

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

Recent Advances in Bioimaging for Cancer Research

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