Multifunctional nanoparticles as theranostic agents for therapy and imaging of breast cancer

Fernandes, Donald A.; Fernandes, Dennis D.; Malik, Aqsa; Gomes, Gregory-Neal W.; Appak-Baskoy, Sıla; Berndl, Elizabeth S. L.; Gradinaru, Claudiu C.; Kolios, Michael C.

doi:10.1016/j.jphotobiol.2020.112110

Cited by 22 publications

(9 citation statements)

References 69 publications

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“…Biodegradability and biocompatibility as well as the possibility to obtain SiNPs of various structures make silicon a promising material for use in the various fields of science, technology, and medicine. In medicine, SiNPs and its composites with organic and inorganic components have mostly been studied to deliver drugs to tumors [18,21] or to regenerate bone tissue [22]. Gold nanoparticles (AuNPs) are used in bionanotechnology due to the possibility of surface modification through a variety of functional groups.…”

Section: Introductionmentioning

confidence: 99%

Silicon–Gold Nanoparticles Affect Wharton’s Jelly Phenotype and Secretome during Tri-Lineage Differentiation

Svirshchevskaya

Sharonova

Полтавцева

et al. 2022

IJMS

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Multiple studies have demonstrated that various nanoparticles (NPs) stimulate osteogenic differentiation of mesenchymal stem cells (MSCs) and inhibit adipogenic ones. The mechanisms of these effects are not determined. The aim of this paper was to estimate Wharton’s Jelly MSCs phenotype and humoral factor production during tri-lineage differentiation per se and in the presence of silicon–gold NPs. Silicon (SiNPs), gold (AuNPs), and 10% Au-doped Si nanoparticles (SiAuNPs) were synthesized by laser ablation, characterized, and studied in MSC cultures before and during differentiation. Humoral factor production (n = 41) was analyzed by Luminex technology. NPs were nontoxic, did not induce ROS production, and stimulated G-CSF, GM-CSF, VEGF, CXCL1 (GRO) production in four day MSC cultures. During MSC differentiation, all NPs stimulated CD13 and CD90 expression in osteogenic cultures. MSC differentiation resulted in a decrease in multiple humoral factor production to day 14 of incubation. NPs did not significantly affect the production in chondrogenic cultures and stimulated it in both osteogenic and adipogenic ones. The major difference in the protein production between osteogenic and adipogenic MSC cultures in the presence of NPs was VEGF level, which was unaffected in osteogenic cells and 4–9 times increased in adipogenic ones. The effects of NPs decreased in a row AuNPs > SiAuNPs > SiNPs. Taken collectively, high expression of CD13 and CD90 by MSCs and critical level of VEGF production can, at least, partially explain the stimulatory effect of NPs on MSC osteogenic differentiation.

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Section: Introductionmentioning

confidence: 99%

Silicon–Gold Nanoparticles Affect Wharton’s Jelly Phenotype and Secretome during Tri-Lineage Differentiation

Svirshchevskaya

Sharonova

Полтавцева

et al. 2022

IJMS

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“…Fernades et al developed the cancer therapy platform based on perfluorohexane nanoemulsions coupled to silica-coated gold nanoparticles [162]. In this formulation, the therapeutic effect is reached due to laser-induced optical absorption followed by the evaporation of the emulsion, causing internal damage to cells.…”

Section: Exposure Limits Correction Factor Cmentioning

confidence: 99%

Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials

Voronin

Abalymov

Svenskaya

et al. 2021

IJMS

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The increased research activity aiming at improved delivery of pharmaceutical molecules indicates the expansion of the field. An efficient therapeutic delivery approach is based on the optimal choice of drug-carrying vehicle, successful targeting, and payload release enabling the site-specific accumulation of the therapeutic molecules. However, designing the formulation endowed with the targeting properties in vitro does not guarantee its selective delivery in vivo. The various biological barriers that the carrier encounters upon intravascular administration should be adequately addressed in its overall design to reduce the off-target effects and unwanted toxicity in vivo and thereby enhance the therapeutic efficacy of the payload. Here, we discuss the main parameters of remote-controlled drug delivery systems: (i) key principles of the carrier selection; (ii) the most significant physiological barriers and limitations associated with the drug delivery; (iii) major concepts for its targeting and cargo release stimulation by external stimuli in vivo. The clinical translation for drug delivery systems is also described along with the main challenges, key parameters, and examples of successfully translated drug delivery platforms. The essential steps on the way from drug delivery system design to clinical trials are summarized, arranged, and discussed.

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“…A variety of nanoparticles have been tested as potential delivery and imaging agents. − Gold nanoparticles (GNPs) have been identified as promising imaging candidates , and have potential controlled release properties . GNP systems have additional possibilities for engendering triggered release as they can “explode” in response to high-energy pulsed laser radiation .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Hybrid Lipid Nanoparticles Containing Gold Nanoparticles and a Weak Base Drug

et al. 2022

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Hybrid lipid nanoparticles containing gold nanoparticles (LNP-GNPs) and drugs have potential for imaging applications as well as triggered release of LNP contents in response to pulsed laser or X-ray radiation mediated by the GNPs. However, methods to synthesize LNP-GNP systems that efficiently entrap GNPs (the potential triggered release and imaging agent) and then load and retain the drug cargo in a manner that may have clinical applications have proven elusive. Here, we develop a straightforward “bottom-up” approach to manufacture drug-loaded LNP-GNP systems. We show that negatively charged GNPs of 5 nm diameter can be stably loaded into LNPs containing 10 mol % ionizable cationic lipid using an ethanol dilution, rapid mixing approach and that these systems also exhibit aqueous compartments. Further, we show that such systems can also entrap ammonium sulfate, enabling pH-dependent loading of the weak base anti-cancer drug doxorubicin into the aqueous compartments. Cryo-transmission electron microscopy (Cryo-TEM) imaging clearly demonstrates the presence of GNPs in the interior of the resulting hybrid nanostructures as well as the formation of electron-dense drug precipitates in the aqueous core of the LNP-GNPs. The approach described here is a robust and straightforward method to generate hybrid LNP-GNP-drug and other LNP-metal nanoparticle-drug systems with potential applications for a variety of triggered release protocols.

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Multifunctional nanoparticles as theranostic agents for therapy and imaging of breast cancer

Cited by 22 publications

References 69 publications

Silicon–Gold Nanoparticles Affect Wharton’s Jelly Phenotype and Secretome during Tri-Lineage Differentiation

Silicon–Gold Nanoparticles Affect Wharton’s Jelly Phenotype and Secretome during Tri-Lineage Differentiation

Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials

Synthesis and Characterization of Hybrid Lipid Nanoparticles Containing Gold Nanoparticles and a Weak Base Drug

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