Multifunctional nanoliposomes with curcumin–lipid derivative and brain targeting functionality with potential applications for Alzheimer disease

Mourtas, Spyridon; Lazar, Adina N.; Markoutsa, Eleni; Duyckaerts, Charles; Antimisiaris, Sophia G.

doi:10.1016/j.ejmech.2014.04.050

Cited by 212 publications

(103 citation statements)

References 31 publications

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“…Oxidative damage and inflammatory processes are known to be particularly high in the brains of Alzheimer patients, and as the aqueous extract of turmeric reduces and prevents oxidation, it may be used concurrently in long-term therapy (46)(47)(48)(49).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Biological and therapeutic activities, and anticancer properties of curcumin

Perrone

Ardito

Giannatempo

et al. 2015

Experimental and Therapeutic Medicine

258

186

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Abstract. Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant. Curcumin has been used extensively in Ayurvedic medicine, as it is nontoxic and exhibits a variety of therapeutic properties, including antioxidant, analgesic, anti-inflammatory and antiseptic activities. Recently, certain studies have indicated that curcumin may exert anticancer effects in a variety of biological pathways involved in mutagenesis, apoptosis, tumorigenesis, cell cycle regulation and metastasis. The present study reviewed previous studies in the literature, which support the therapeutic activity of curcumin in cancer. In addition, the present study elucidated a number of the challenges concerning the use of curcumin as an adjuvant chemotherapeutic agent. All the studies reviewed herein suggest that curcumin is able to exert anti-inflammatory, antiplatelet, antioxidative, hepatoprotective and antitumor activities, particularly against cancers of the liver, skin, pancreas, prostate, ovary, lung and head neck, as well as having a positive effect in the treatment of arthritis.

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Section: Antioxidant Activitymentioning

confidence: 99%

Biological and therapeutic activities, and anticancer properties of curcumin

Perrone

Ardito

Giannatempo

et al. 2015

Experimental and Therapeutic Medicine

258

186

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“…139,144 Reducing the size of the curcumin compound to the nanolevel and formulating it with polyesters leads to higher bioavailability in systemic circulation. 122,123,144,155 Many studies have confirmed that nanosizing curcumin enhances bioavailability and therapeutic efficiency for many diseases including PD. 6,13,29,31,67,94,108,122,138,139 Nanocurcumin greatly reduces the oxidative stress and apoptosis in the brain of PD flies.…”

Section: Nanocurcuminmentioning

confidence: 99%

“…122 In vitro studies of multifunctional curcumin nanoliposomes proved their ability to cross the blood-brain barrier and were effective against Alzheimer's disease. 123 Nanoniosomes Nanoniosomes are liposomes made of nonionic surfactant type vesicles at a nanosize ranging from 10 to 1,000 nm. These niosomes can bind both hydrophilic and hydrophobic bioactive compounds for enhanced delivery.…”

Section: 109mentioning

confidence: 99%

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

102

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Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson’s disease (PD), which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived bioactive compounds with important roles in the prevention and treatment of PD. However, in vivo studies suggest that their concentrations are very low to cross blood–brain barrier thereby it limits bioavailability, stability, and dissolution at target sites in the brain. To overcome these problems, nanophytomedicine with the controlled size of 1–100 nm is used to maximize efficiency in the treatment of PD. Nanosizing of phytobioactive compounds enhances the permeability into the brain with maximized efficiency and stability. Several nanodelivery techniques, including solid lipid nanoparticles, nanostructured lipid carriers, nanoliposomes, and nanoniosomes can be used for controlled delivery of nanobioactive compounds to brain. Nanocompounds, such as ginsenosides (19.9 nm) synthesized using a nanoemulsion technique, showed enhanced bioavailability in the rat brain. Here, we discuss the most recent trends and applications in PD, including 1) the role of phytobioactive compounds in reducing oxidative stress and their bioavailability; 2) the role of nanotechnology in reducing oxidative stress during PD; 3) nanodelivery systems; and 4) various nanophytobioactive compounds and their role in PD.

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“…These results prove the potential of such multifunctional liposomes for application in AD treatment and diagnosis. 42 Curcumin-conjugated liposomes were developed and the results showed significant amounts of labeled Aβ deposits in postmortem brain tissue of AD patients. In vivo injection in the hippocampus and in the neocortex of mice showed that curcumin-conjugated nanoliposomes were able to specifically stain the Aβ deposits.…”

mentioning

confidence: 99%

Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease

Fonseca-Santos¹,

Chorilli²,

Gremião³

2015

IJN

248

160

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Alzheimer’s disease is a neurological disorder that results in cognitive and behavioral impairment. Conventional treatment strategies, such as acetylcholinesterase inhibitor drugs, often fail due to their poor solubility, lower bioavailability, and ineffective ability to cross the blood–brain barrier. Nanotechnological treatment methods, which involve the design, characterization, production, and application of nanoscale drug delivery systems, have been employed to optimize therapeutics. These nanotechnologies include polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion, nanoemulsion, and liquid crystals. Each of these are promising tools for the delivery of therapeutic devices to the brain via various routes of administration, particularly the intranasal route. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease.

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Multifunctional nanoliposomes with curcumin–lipid derivative and brain targeting functionality with potential applications for Alzheimer disease

Cited by 212 publications

References 31 publications

Biological and therapeutic activities, and anticancer properties of curcumin

Biological and therapeutic activities, and anticancer properties of curcumin

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease

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Multifunctional nanoliposomes with curcumin–lipid derivative and brain targeting functionality with potential applications for Alzheimer disease

Cited by 212 publications

References 31 publications

Biological and therapeutic activities, and anticancer properties of curcumin

Biological and therapeutic activities, and anticancer properties of curcumin

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

Nanotechnology-based drug delivery systems for the treatment of Alzheimer&rsquo;s disease

Contact Info

Product

Resources

About

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease