Multifunctional Nanofibers for Specific Purification and Release of CTCs

Wang, Zhili; Sun, Na; Liu, Min; Cao, Yi; Wang, Kewei; Wang, Jine; Pei, Renjun

doi:10.1021/acssensors.7b00048

Cited by 43 publications

(39 citation statements)

References 37 publications

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“…Moreover, the spacer-to-transferrin ratio played also an important role on the system efficiency. Three linkers per transferrin gave the highest capturing values for all the polymer lengths that reached a top value of 81% for PEG 8 . Moreover, the use of a bigger thermoresponsive polymer on the construction of the MNG had a negative effect on the capturing ability of the system.…”

Section: Discussionmentioning

confidence: 99%

“…The 1:1 ratio did not guarantee effective CTC capturing, giving values of about 30%. With a ratio of 1:3, about 60% of the CTCs were captured with PEG 4 and PEG 12 and, even more interestingly, an 81% capturing efficiency was achieved with PEG 8 . Above a ratio of 1:3, the increase of linker per Tf decreased the capturing efficiency of the system.…”

Section: Ctc Capture Efficiency In An Artificial Ctc Suspensionmentioning

confidence: 96%

“…Different strategies have emerged in recent decades for using materials that match the requirements for capturing CTCs in blood with efficiencies ranging from 50% to 99% [3][4][5][6]. Among them, methodologies based on Velcro-like devices [7,8], biomimetic nano-platforms [9], microfluidic devices such as CTC-chips [1,10,11], DEPArray systems [12] or CTC enrichment [13,14] have been developed.…”

Section: Introductionmentioning

confidence: 99%

“…Herein we extend our previous study, investigating the key effect of the linker used to couple the Tf ligand to the MNGs and achieve efficient CTC capture using blood samples from cancer patients. To understand and improve the system's capturing efficiency, the interplay between the PEG linker lengths (4,8,and 12 EG units) and the Tf-to-linker ratio (1:1, 1:3, 1:5 and 1:9) was screened.…”

Section: Introductionmentioning

confidence: 99%

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Optimizing Circulating Tumor Cells’ Capture Efficiency of Magnetic Nanogels by Transferrin Decoration

et al. 2018

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Magnetic nanogels (MNGs) are designed to have all the required features for their use as highly efficient trapping materials in the challenging task of selectively capturing circulating tumor cells (CTCs) from the bloodstream. Advantageously, the discrimination of CTCs from hematological cells, which is a key factor in the capturing process, can be optimized by finely tuning the polymers used to link the targeting moiety to the MNG. We describe herein the relationship between the capturing efficiency of CTCs with overexpressed transferrin receptors and the different strategies on the polymer used as linker to decorate these MNGs with transferrin (Tf). Heterobifunctional polyethylene glycol (PEG) linkers with different molecular weights were coupled to Tf in different ratios. Optimal values over 80% CTC capture efficiency were obtained when 3 PEG linkers with a length of 8 ethylene glycol (EG) units were used, which reveals the important role of the linker in the design of a CTC-sorting system.

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Section: Discussionmentioning

confidence: 99%

Section: Ctc Capture Efficiency In An Artificial Ctc Suspensionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Optimizing Circulating Tumor Cells’ Capture Efficiency of Magnetic Nanogels by Transferrin Decoration

et al. 2018

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“…These brushes are designed to enable white blood cells to detach from aptamer‐poly( N ‐isopropylacrylamide)/chitosan nanofiber surfaces during the conformational transition. Meanwhile, these specific captured circulating tumor cells (CTCs) are retained at a high purity …”

Section: Nanofiber For Air Water and Blood Purificationmentioning

confidence: 99%

Nanofibers for Biomedical and Healthcare Applications

Rasouli

Barhoum

Bechelany

et al. 2018

Macromolecular Bioscience

196

112

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Unique features of nanofibers provide enormous potential in the field of biomedical and healthcare applications. Many studies have proven the extreme potential of nanofibers in front of current challenges in the medical and healthcare field. This review highlights the nanofiber technologies, unique properties, fabrication techniques (i.e., physical, chemical, and biological methods), and emerging applications in biomedical and healthcare fields. It summarizes the recent researches on nanofibers for drug delivery systems and controlled drug release, tissue‐engineered scaffolds, dressings for wound healing, biosensors, biomedical devices, medical implants, skin care, as well as air, water, and blood purification systems. Attention is given to different types of fibers (e.g., mesoporous, hollow, core‐shell nanofibers) fabricated from various materials and their potential biomedical applications.

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Nanomaterial‐Based Strategies for Preventing Tumor Metastasis by Interrupting the Metastatic Biological Processes

Cai,

He,

Zhou

et al. 2024

Adv Healthcare Materials

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Tumor metastasis is the primary cause of cancer‐related deaths. The prevention of tumor metastasis has garnered notable interest and interrupting metastatic biological processes is considered a potential strategy for preventing tumor metastasis. The tumor microenvironment (TME), circulating tumor cells (CTCs), and pre‐metastatic niche (PMN) play crucial roles in metastatic biological processes. These processes can be interrupted using nanomaterials due to their excellent physicochemical properties. However, most studies have focused on only one aspect of tumor metastasis. Here, we highlight the hypothesis that nanomaterials can be used to target metastatic biological processes and explore strategies to prevent tumor metastasis. First, we briefly summarized the metastatic biological processes and strategies involving nanomaterials acting on the TME, CTCs, and PMN to prevent tumor metastasis. Further, we discussed the current challenges and prospects of nanomaterials in preventing tumor metastasis by interrupting metastatic biological processes. Nanomaterial‐and multifunctional nanomaterial‐based strategies for preventing tumor metastasis are advantageous for the long‐term fight against tumor metastasis and their continued exploration will facilitate rapid progress in the prevention, diagnosis, and treatment of tumor metastasis. We have outlined novel perspectives for developing more effective strategies to prevent tumor metastasis, thereby improving the outcomes of patients with cancer.This article is protected by copyright. All rights reserved

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Multifunctional Nanofibers for Specific Purification and Release of CTCs

Cited by 43 publications

References 37 publications

Optimizing Circulating Tumor Cells’ Capture Efficiency of Magnetic Nanogels by Transferrin Decoration

Optimizing Circulating Tumor Cells’ Capture Efficiency of Magnetic Nanogels by Transferrin Decoration

Nanofibers for Biomedical and Healthcare Applications

Nanomaterial‐Based Strategies for Preventing Tumor Metastasis by Interrupting the Metastatic Biological Processes

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