Multifunctional nanocomposite clusters enabled by amphiphilic/bioactive natural polysaccharides

Park, Jeong Chan; Park, Tae Yoon; Kim, Do Hyeon; Joon, Hyung; Seo, Jeong Hyun

doi:10.1016/j.cej.2019.122406

Cited by 11 publications

(12 citation statements)

References 68 publications

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“…The r 2 values of Amp-SA-M fabricated with 1 and 3% amphiphilic polysaccharides concentrations were 374.9 and 388.7 mM –1 s –1 , respectively (Figure A). The similar r 2 values of Amp-SA-M (1%) and Amp-SA-M (3%) would be attributed to the dependence of r 2 of self-assembled clusters on their sizes, where they are in static dephasing regime or weak magnetic regime, reaching a plateau or causing reduced r 2 values, respectively, which is predicted by the outer-sphere relaxation theory. , Amp-SA-M exhibited around 2.7–2.8-fold higher values in r 2 relaxivity than those (139.5 mM –1 s –1 ) of MNPs-Cit, which is in accordance with the previous observation that the clusters of magnetic NPs have higher r 2 than that of single magnetic NPs. , In contrast, as depicted in Figure B, Amp-SA-M (1%) and Amp-SA-M (3%) demonstrated lower r 1 relaxivities than MNPs-Cit that have a hydrophilic layer alone, which is attributed to the hydrophobic inner layer of Amp-SA-M, thus restricting water molecule diffusion into the inner layer, thereby significantly enhancing r 2 / r 1 ratios (1288.3 and 661.1) of Amp-SA-M compared with those (74.8) of MNPs-Cit (Figure C). Amp-SA-M (1%) achieved ∼17.2-fold higher values in r 2 / r 1 ratios than MNPs-Cit.…”

Section: Resultssupporting

confidence: 53%

“…They are generally regarded as safe and biologically suitable and have been widely exploited in biomedical applications. Recently, we reported the self-assembly of amphiphilic polysaccharides and hydrophobic NPs that have been demonstrated via a simple ultrasonication method …”

Section: Introductionmentioning

confidence: 99%

“…Recently, we reported the selfassembly of amphiphilic polysaccharides and hydrophobic NPs that have been demonstrated via a simple ultrasonication method. 8 Electrohydrodynamic techniques (i.e., electrospraying and electrospinning) have been widely employed for producing micro-or nanoarchitectures, which are suitable for multifarious applications in the biomedical area and biotechnology. 9,10 When it comes to creating nano/microparticulates with polymeric solutions such as synthetic polymers and biopolymers, including carbohydrates and substances of protein origin, electrospraying has been found to be one of the most efficient methods, in terms of size homogeneity, its facile and expeditious procedures, scale-up productivity, and efficient encapsulation competence.…”

Section: ■ Introductionmentioning

confidence: 99%

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Electrohydrodynamic Sprayable Amphiphilic Polysaccharide-Clasped Nanoscale Self-Assembly for In Vivo Imaging

Park

Kim

Song

et al. 2020

ACS Appl. Mater. Interfaces

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The work presented in this report demonstrates that amphiphilic polysaccharide-clasped self-assembly (Amp-SA) with nanometer size, encapsulating hydrophobic nanoparticles (NPs) can be generated via electrohydrodynamic spraying. It is observed that the formation of hydrophobic NP-encapsulated Amp-SA is dependent on the surface chemistry of NPs. The citrate-coated magnetic NPs (MNPs-Cit) were also prepared and compared. The hydrophobic magnetic NP-encapsulated Amp-SA (Amp-SA-M) exhibited around 2.7–2.8-fold higher values in r 2 relaxivity than that of MNPs-Cit. In addition, the resulting Amp-SA-M achieved ∼17.2-fold higher values in r 2/r 1 ratios than MNPs-Cit. The enhanced performances in magnetic transverse (r 2) relaxivity and r 2/r 1 ratio as well as the in vivo behavior of Amp-SA-M suggest the potential of Amp-SA-M as a promising MRI nanoprobe. This approach based on the nature-originated amphiphilic biopolymers may provide a novel insight into electrohydrodynamic techniques that have the ability to create various nanostructures, encapsulating high-quality hydrophobic nanomaterials for applications in diverse biotechnology.

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Section: Resultssupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

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Electrohydrodynamic Sprayable Amphiphilic Polysaccharide-Clasped Nanoscale Self-Assembly for In Vivo Imaging

Park

Kim

Song

et al. 2020

ACS Appl. Mater. Interfaces

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“…MRI is a tool that is widely applied for multimodal imaging. − A-MPCS HNCs have a dual role in MRI and PAI, originating from the IO cores and Au shells. Thus, the PAI contrast ability of A-MPCS HNCs was examined.…”

Section: Resultsmentioning

confidence: 99%

Polysaccharide–Hydrophobic Nanoparticle Hybrid Nanoclusters for Enhanced Performance in Magnetic Resonance/Photoacoustic Imaging

et al. 2019

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Polysaccharide−nanoparticle (NP) hybrid nanoclusters have great potential to revitalize diverse bioapplications; however, fabricating polysaccharide-based hybrid nanoclusters composed of high-quality NPs generated in the organic phase remains a challenge. Here, using calcium alginate as a polysaccharide/tetramethylammonium hydroxide (TMAOH) combination, we report a novel approach to the design of alginate−hydrophobic magnetic−plasmonic core−shell (MPCS) NP hybrid nanoclusters (A-MPCS HNCs). Furthermore, we observe the dependence of the formation of A-MPCS HNCs on the TMAOH concentration. The enhanced performance in both magnetic resonance r 2 relaxivity and photoacoustic (PA) signals and the biocompatibility/bioactivity as well as the in vivo performance of A-MPCS HNCs shows them to be a promising magnetic resonance/photoacoustic dual-mode imaging agent. Our strategy could open doors to the use of other precious highquality nanomaterials created in the organic phase via well-established synthetic chemistry in the design of alginate− hydrophobic nanomaterial hybrid nanoclusters, giving rise to novel and multifarious bioapplications.

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“…Microbial EPSs are high-molecular-weight (usually from 10 4 to 10 7 Da) carbohydrate polymers composed of homo- or hetero-monosaccharides, and they play essential roles in biological systems including host–pathogen interactions, cell signaling, receptor–ligand interaction, and biofilm formation . In addition, EPSs have potential applications in many fields, such as food, feed, cosmetics, bioremediation, biomedicine, and green manufacturing industries, , as they are cost-effective, biodegradable, safe, accessible, reusable, and environmentally friendly. To date, new types of valuable EPS species with different functions are continuously being explored for different purposes and applications.…”

Section: Introductionmentioning

confidence: 99%

Naturally Occurring Exopolysaccharide Nanoparticles: Formation Process and Their Application in Glutathione Detection

Zhang

Guo

et al. 2021

ACS Appl. Mater. Interfaces

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Naturally occurring nanoscale exopolysaccharide (EPS) has attracted much attention in recent years. In this research, we obtained a new kind of naturally occurring spherical EPS nanoparticles (EPS-R503) from Lactobacillus plantarum R503. The secretion, self-assembly process, morphological structure, and surface characteristics of the as-prepared nanoparticles were comprehensively revealed with transmission electron microscopy (TEM) and atomic force microscope (AFM) for the first time. It was found that the EPS-R503 nanoparticles consist of negatively charged heteropolysaccharide composed of mannose, glucose, galactose, and glucuronide with several functional groups including −OH, −COOH, and −NH 2 . When different solvents were used to treat the EPS-R503 nanoparticles, the morphological structure and surface properties could be changed or manipulated. The forming mechanism of EPS-R503 was elucidated based on the aggregation processes from a fundamental point of view. Furthermore, EPS-R503 can serve as reducing and stabilizing agents for the biosynthesis of manganese dioxide nanosheets (MnO 2 NSs), leading to EPS-MnO 2 nanocomposite. The as-prepared nanocomposites can absorb fluorescein (FL) to form EPS-MnO 2 -FL, which can be used to detect glutathione (GSH) with a low limit of detection (0.16 μM) and a wide detection range from 0.05 to 4 mM. The excellent biocompatibility of EPS-MnO 2 -FL endows the feasibility of in vivo detection of GSH as well. Overall, the findings from this work not only benefit the exploitation of naturally occurring EPS nanomaterials but also provide a novel strategy for the green synthesis of metal-containing nanosheets for GSH detection.

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Multifunctional nanocomposite clusters enabled by amphiphilic/bioactive natural polysaccharides

Cited by 11 publications

References 68 publications

Electrohydrodynamic Sprayable Amphiphilic Polysaccharide-Clasped Nanoscale Self-Assembly for In Vivo Imaging

Electrohydrodynamic Sprayable Amphiphilic Polysaccharide-Clasped Nanoscale Self-Assembly for In Vivo Imaging

Polysaccharide–Hydrophobic Nanoparticle Hybrid Nanoclusters for Enhanced Performance in Magnetic Resonance/Photoacoustic Imaging

Naturally Occurring Exopolysaccharide Nanoparticles: Formation Process and Their Application in Glutathione Detection

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