Multifunctional nanocomplex for surface-enhanced Raman scattering imaging and near-infrared photodynamic antimicrobial therapy of vancomycin-resistant bacteria

Zhou, Zilong; Peng, Shanshan; Sui, Minghao; Chen, Shiguang; Huang, Lishi; Xu, Hui; Jiang, Tingting

doi:10.1016/j.colsurfb.2017.11.005

Cited by 47 publications

(32 citation statements)

References 32 publications

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“…These platform demonstrated ultrasensitive detections for circulating bacterial cells (CBCs), in vivo magnetic enrichment and PT eradication of CBCs (Galanzha et al, 2012 ). Recently, Zhou and collaborators developed a silicon 2,3-naphthalocyanine dihydroxide (Nc) and Vancomycin functionalized silica-encapsulated, silver-coated gold NPs (Au@AgNP@SiO2@Nc-Van) as a novel theranostic system for surface-enhanced Raman scattering (SERS) detection and antimicrobial photodynamic therapy (aPDT) of vancomycin (Van)-resistant enterococci (VRE) strains (Zhou et al, 2018 ). These authors observed a 4–5 logs reduction of bacteria upon in vitro aPDT of VRE treated with a nanomolar concentration of the Au@AgNP@SiO2@Nc-Van and an infection regression and even complete eradication of VRE in vivo using infected mice (Zhou et al, 2018 ).…”

Section: The Potential For Nanotheranosticsmentioning

confidence: 99%

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

McCusker²,

et al. 2018

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Infectious diseases remain one of the leading causes of morbidity and mortality worldwide. The WHO and CDC have expressed serious concern regarding the continued increase in the development of multidrug resistance among bacteria. Therefore, the antibiotic resistance crisis is one of the most pressing issues in global public health. Associated with the rise in antibiotic resistance is the lack of new antimicrobials. This has triggered initiatives worldwide to develop novel and more effective antimicrobial compounds as well as to develop novel delivery and targeting strategies. Bacteria have developed many ways by which they become resistant to antimicrobials. Among those are enzyme inactivation, decreased cell permeability, target protection, target overproduction, altered target site/enzyme, increased efflux due to over-expression of efflux pumps, among others. Other more complex phenotypes, such as biofilm formation and quorum sensing do not appear as a result of the exposure of bacteria to antibiotics although, it is known that biofilm formation can be induced by antibiotics. These phenotypes are related to tolerance to antibiotics in bacteria. Different strategies, such as the use of nanostructured materials, are being developed to overcome these and other types of resistance. Nanostructured materials can be used to convey antimicrobials, to assist in the delivery of novel drugs or ultimately, possess antimicrobial activity by themselves. Additionally, nanoparticles (e.g., metallic, organic, carbon nanotubes, etc.) may circumvent drug resistance mechanisms in bacteria and, associated with their antimicrobial potential, inhibit biofilm formation or other important processes. Other strategies, including the combined use of plant-based antimicrobials and nanoparticles to overcome toxicity issues, are also being investigated. Coupling nanoparticles and natural-based antimicrobials (or other repurposed compounds) to inhibit the activity of bacterial efflux pumps; formation of biofilms; interference of quorum sensing; and possibly plasmid curing, are just some of the strategies to combat multidrug resistant bacteria. However, the use of nanoparticles still presents a challenge to therapy and much more research is needed in order to overcome this. In this review, we will summarize the current research on nanoparticles and other nanomaterials and how these are or can be applied in the future to fight multidrug resistant bacteria.

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Section: The Potential For Nanotheranosticsmentioning

confidence: 99%

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

McCusker²,

et al. 2018

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“…The use of a gold nanoparticle hybrid assembly for surface‐enhanced Raman scattering (SERS) imaging and near‐infrared photodynamic antimicrobial therapy of live vancomycin‐resistant enterococci strains is illustrated in Figure . [ 235 ] Sixty nanometer‐diameter Au nanoparticles are first coated with silver (Au@AgNPs) to generate a plasmonic nanoparticle core for emission of SERS signals. A silica shell is subsequently created over the Au@AgNP for conjugation with silicon 2,3‐napthalocyanine dihydroxide (Nc) for conjugation of vancomycin (Van).…”

Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

473

368

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Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface-colonized microbes pose serious problems to the society from both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or on the surface of materials, or by coatings, to prevent microbial adhesion or kill the microorganisms after their attachment to biofilms, represents an important strategy in an increasingly challenging field. Over the last decade, many studies have been devoted to preparing meta-based nanomaterials that possess antibacterial, antiviral, and antifungal activities to combat pathogen-related diseases. Herein, an overview on the state-of-the-art antimicrobial nanosized metal-based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets. The antimicrobial mechanism of these nanostructures and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry are discussed. Their properties as well as potential caveats such as cytotoxicity, diminishing efficacy, and induction of antimicrobial resistance of materials incorporating these nanostructures are reviewed to provide a backdrop for future research.

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“…Fabrication of PS into suitable drug delivery forms may be critical for a high anti-biofilm efficacy. Various nanoparticles such as chitosan nanoparticles (Darabpour et al, 2016 ), silver nanoparticles (Zhou et al, 2017 ), and graphene oxide (Xie et al, 2017 ) have been shown to be useful, while the particle size and incubation time appear to be crucial for controlling S. mutans and C. albicans biofilm and require further optimization (Chen et al, 2012 ). Moreover, the PS drug concentration also requires to be optimized (Araújo et al, 2014 ; Luke-Marshall et al, 2014 ).…”

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy to Control Clinically Relevant Biofilm Infections

et al. 2018

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Biofilm describes a microbially-derived sessile community in which microbial cells are firmly attached to the substratum and embedded in extracellular polymeric matrix. Microbial biofilms account for up to 80% of all bacterial and fungal infections in humans. Biofilm-associated pathogens are particularly resistant to antibiotic treatment, and thus novel antibiofilm approaches needed to be developed. Antimicrobial Photodynamic therapy (aPDT) had been recently proposed to combat clinically relevant biofilms such as dental biofilms, ventilator associated pneumonia, chronic wound infections, oral candidiasis, and chronic rhinosinusitis. aPDT uses non-toxic dyes called photosensitizers (PS), which can be excited by harmless visible light to produce reactive oxygen species (ROS). aPDT is a multi-stage process including topical PS administration, light irradiation, and interaction of the excited state with ambient oxygen. Numerous in vitro and in vivo aPDT studies have demonstrated biofilm-eradication or substantial reduction. ROS are produced upon photo-activation and attack adjacent targets, including proteins, lipids, and nucleic acids present within the biofilm matrix, on the cell surface and inside the microbial cells. Damage to non-specific targets leads to the destruction of both planktonic cells and biofilms. The review aims to summarize the progress of aPDT in destroying biofilms and the mechanisms mediated by ROS. Finally, a brief section provides suggestions for future research.

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Multifunctional nanocomplex for surface-enhanced Raman scattering imaging and near-infrared photodynamic antimicrobial therapy of vancomycin-resistant bacteria

Cited by 47 publications

References 32 publications

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Antimicrobial Photodynamic Therapy to Control Clinically Relevant Biofilm Infections

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