Multifunctional motion-to-color janus transducers for the rapid detection of sepsis biomarkers in whole blood

Russell, Steven M.; Alba-Patiño, Alejandra; Borges, Marcio; Rica, Roberto de la

doi:10.1016/j.bios.2019.111346

Cited by 32 publications

(45 citation statements)

References 33 publications

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“…Finally, the Fourier-transform technique was employed to covert increased share stress of GNDs as frequency shift to captured biotarget, such as the influenza virus (HA1). [332] Other immunoassays-based microrobot have been applied to detect carcinoembryonic antigen, [333] proteins, [334] bacterial toxins, [335] cortisol, [336] glucose, [337][338][339] sepsis, [340] andgalactosidase. [341]…”

Section: Biosensorsmentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization of these robotic platforms has led to numerous applications that leverages precision medicine. In this review, the current trends of medical micro and nanorobotics for therapy, surgery, diagnosis, and medical imaging are discussed. The use of micro and nanorobots in precision medicine still faces technical, regulatory, and market challenges for their widespread use in clinical settings. Nevertheless, recent translations from proof of concept to in vivo studies demonstrate their potential toward precision medicine.

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Section: Biosensorsmentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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“…1 Schematic representation of the plasmonic mobile biosensors (a) antibody-decorated gold nanoparticles generate colored spots on paper substrates; (b) the color in the spots is quantified with an app that uses a virtual frame to control the angle and distance between the biosensor and the smartphone; (c) the detection screen appears after aligning the frame in the AR guidance system with the biosensor and pressing the Set button, and the app automatically detects the region of interest (ROI) while at the same time sampling background signals from 4 points around the ROI to avoid interference from uneven lighting. 18 (d) When the app has measured 50 valid points, the progress bar stops and the resulting increase in pixel intensity is displayed (see Video S1 in the ESI †). Ab: antibody, IL-6: interleukin 6, AuNP: gold nanoparticle, and AR: augmented reality.…”

Section: Resultsmentioning

confidence: 99%

Nanoparticle-based mobile biosensors for the rapid detection of sepsis biomarkers in whole blood

et al. 2020

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“…Russel et al developed an interesting approach to detect the sepsis biomarker procalcitonin (PCT) [317]. They used self-propelled Janus nanoparticles for the colorimetric determination of particle motion.…”

Section: Organic Nanomaterials Applications For Healthcare Biosensingmentioning

confidence: 99%

“…( a ) Molecular machine with a Janus coating responsible for biorecognition, and iron oxide core providing colorimtric and magnetic properties ( b ) Signal generation mechanism: after spotting the particles on a piece of filter paper H 2 O 2 is added; the catalase enzymes generate bubbles that propel the particles and disperse the color within seconds. The subsequent change in pixel intensity is read in real time with a mobile phone app [317]. …”

Section: Figurementioning

confidence: 99%

Nanomaterials for Healthcare Biosensing Applications

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Altıntaş

2019

Sensors

171

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In recent years, an increasing number of nanomaterials have been explored for their applications in biomedical diagnostics, making their applications in healthcare biosensing a rapidly evolving field. Nanomaterials introduce versatility to the sensing platforms and may even allow mobility between different detection mechanisms. The prospect of a combination of different nanomaterials allows an exploitation of their synergistic additive and novel properties for sensor development. This paper covers more than 290 research works since 2015, elaborating the diverse roles played by various nanomaterials in the biosensing field. Hence, we provide a comprehensive review of the healthcare sensing applications of nanomaterials, covering carbon allotrope-based, inorganic, and organic nanomaterials. These sensing systems are able to detect a wide variety of clinically relevant molecules, like nucleic acids, viruses, bacteria, cancer antigens, pharmaceuticals and narcotic drugs, toxins, contaminants, as well as entire cells in various sensing media, ranging from buffers to more complex environments such as urine, blood or sputum. Thus, the latest advancements reviewed in this paper hold tremendous potential for the application of nanomaterials in the early screening of diseases and point-of-care testing.

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Multifunctional motion-to-color janus transducers for the rapid detection of sepsis biomarkers in whole blood

Cited by 32 publications

References 33 publications

Medical Micro/Nanorobots in Precision Medicine

Medical Micro/Nanorobots in Precision Medicine

Nanoparticle-based mobile biosensors for the rapid detection of sepsis biomarkers in whole blood

Nanomaterials for Healthcare Biosensing Applications

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