Multifunctional metal–organic frameworks for wound healing and skin regeneration

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

“…Specifically, GS5-CL-Ag@CD-MOF embodies a synergistic design where the MOF structure not only facilitates targeted delivery but also contributes intrinsically to the healing process. 211 The inclusion of silver (Ag) within the MOF framework provides antimicrobial properties, a critical factor in preventing infection and promoting wound healing. 209 Furthermore, the cyclodextrin component enhances the solubility and stability of encapsulated drugs, ensuring efficient delivery to the wound site.…”

Nanoparticle-Based Strategies for Managing Biofilm Infections in Wounds: A Comprehensive Review

“…The biocompatibility and toxicity of MOFs remain uncertain, posing challenges due to the significant release of metal ions and organic ligands, the innate characteristics of the material, and the low degradation rate and cellular accumulation of MOFs and their components, which hinders metabolic processes and excretion. 78 2.4. Antibacterial Peptide-Based Nanoparticles.…”

“…Unlike many other nanoparticles, MOFs are still in the early stages of research and demand further investigation. The biocompatibility and toxicity of MOFs remain uncertain, posing challenges due to the significant release of metal ions and organic ligands, the innate characteristics of the material, and the low degradation rate and cellular accumulation of MOFs and their components, which hinders metabolic processes and excretion …”

Lanthanide complexes facilitate wound healing by promoting fibroblast viability, migration and M2 macrophage polarization

“…13 Metal organic frameworks (MOFs) have also drawn a lot of interest due to their potential benefits in treating skin injuries. 14 For example, Chen et al utilized Zn-based MOFs and showed that the porous nature of this materials could rapidly degrade under weakly acidic conditions (pH = 5.5), resulting in the long-term release of zinc ions for wound healing applications. 15 Zhang et al reported the control release of nitric oxide (NO) using Cu-Based MOFs HKUST-1.…”