Multifunctional mesoporous silica nanoparticles for pH-response and photothermy enhanced osteosarcoma therapy

Shi, Qinying; Lu, Ying; Zhang, Guannan; Yang, Xuan; Li, Rong; Zhang, Guoliang; Guo, Xiudong; Song, Jianbo; Ding, Qi

doi:10.1016/j.colsurfb.2022.112615

Cited by 9 publications

(6 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After 7 days, the DAPI/phalloidin-stained microscopic images of the cells treated with 50 μg/mL Meso-SiHAp@MPN demonstrated that hDPSCs survived, proliferated, and maintained cell morphology compared to the untreated control group (Figures B and S8). In addition, the cells in the treated groups showed a more elongated appearance with filamentous legs and lamellae in the microscopic view, indicating that Meso-SiHAp@MPN supported the cell extension . In addition, the cell proliferation and reaching confluency in the treated and control groups are significantly comparable.…”

Section: Resultsmentioning

confidence: 79%

“…In addition, the cells in the treated groups showed a more elongated appearance with filamentous legs and lamellae in the microscopic view, indicating that Meso-SiHAp@MPN supported the cell extension. 13 In addition, the cell proliferation and reaching confluency in the treated and control groups are significantly comparable. Thus, Meso-SiHAp@MPN at a 50 μg/mL concentration is biocompatible, allowing viability for the osteogenesis and mineralization period.…”

Section: ■ Results and Discussionmentioning

confidence: 87%

“…12 Therefore, bioinorganic ions such as calcium, phosphate, and silicate are promising candidates for bone regeneration due to their intrinsic biological activity and chemical similarity to natural bone marrow. 13 Mesoporous silica nanoparticles (MSNs) are inorganic biomaterials with nano-or micropores that provide better osteogenic performance than powder and granular bone fillers. 2 Micropores can enhance cell adhesion and proliferation and accelerate osteogenesis.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Calcium phosphate salts are the major mineral constituents of HA (Ca 10 (PO 4 ) 6 (OH) 2 ) . Therefore, bioinorganic ions such as calcium, phosphate, and silicate are promising candidates for bone regeneration due to their intrinsic biological activity and chemical similarity to natural bone marrow …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Nanocore–Shell Bone Filler Contained Mesoporous Silica Modified with Hydroxyapatite Precursors; Wrapped in a Natural Metal–Phenolic Network

Bahadorani,

Hadadzadeh,

Mirahmadi-Zare

et al. 2023

Langmuir

View full text Add to dashboard Cite

Various therapeutic strategies have been developed to address bone diseases caused by aging society and skeletal defects caused by trauma or accidental events. One such approach is using bone fillers, such as hydroxyapatite (HA) and bioactive glasses. Although they have provided effective osteogenesis, infection and inflammation due to the surgical procedure and uncontrolled ion release can hinder the efficiency of bone regeneration. In response to these challenges, immobilizing a neutral metal−phenolic network on the surface of osteoconductive nanoparticles would be the master key to achieving a gradual, controlled release during the mineralization period and reducing infection and inflammation through biological pathways. In this regard, a mesoporous silica nanocomposite modified by an HA precursor was synthesized to enhance bone regeneration. In addition, to improve the therapeutic effects, its surface was wrapped with a magnesium−phenolic network made from pomegranate extract, which can simultaneously produce anti-inflammatory and antibacterial effects. The obtained core−shell nanocomposite was characterized by its physicochemical properties, biocompatibility, and bioactivity. The in vitro studies revealed that the synthesized nanocomposite exhibits higher osteogenic activity than the control groups, as confirmed by alizarin red staining. Moreover, the nanocomposite maintained low toxicity as measured by the 3-(4,5dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay and increased antibacterial activity against Staphylococcus aureus and Escherichia coli compared with the control groups. Therefore, this research presents a promising strategy for bone regeneration, combining the advantages of mesoporous silica nanocomposite modified by an HA precursor with the beneficial effects of a magnesium−phenolic network.

show abstract

Section: Resultsmentioning

confidence: 79%

Section: ■ Results and Discussionmentioning

confidence: 87%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nanocore–Shell Bone Filler Contained Mesoporous Silica Modified with Hydroxyapatite Precursors; Wrapped in a Natural Metal–Phenolic Network

Bahadorani,

Hadadzadeh,

Mirahmadi-Zare

et al. 2023

Langmuir

View full text Add to dashboard Cite

show abstract

“…Similarly, to precisely regulate the dosage and NO delivery time from polymers, the photoresponsive properties of NO donors have been exploited for various biomedical applications (catheter disinfection, NO inhalation therapy, osteosarcoma therapy, etc. ). ,− Another approach for controlling the location and enabling site-specific NO availability is the use of transnitrosation reactions at thiol moieties ( e.g. , cysteine) that are immobilized on surfaces to provide localized sites for NO at these biointerfaces. − The specific details of these combinational materials are discussed later in this review.…”

Section: Advancements In Nitric Oxide-releasing Multifunctional Biome...mentioning

confidence: 99%

Recent Developments in Multifunctional Antimicrobial Surfaces and Applications toward Advanced Nitric Oxide-Based Biomaterials

Chug

Brisbois

2022

ACS Mater. Au

View full text Add to dashboard Cite

Implant-associated infections arising from biofilm development are known to have detrimental effects with compromised quality of life for the patients, implying a progressing issue in healthcare. It has been a struggle for more than 50 years for the biomaterials field to achieve long-term success of medical implants by discouraging bacterial and protein adhesion without adversely affecting the surrounding tissue and cell functions. However, the rate of infections associated with medical devices is continuously escalating because of the intricate nature of bacterial biofilms, antibiotic resistance, and the lack of ability of monofunctional antibacterial materials to prevent the colonization of bacteria on the device surface. For this reason, many current strategies are focused on the development of novel antibacterial surfaces with dual antimicrobial functionality. These surfaces are based on the combination of two components into one system that can eradicate attached bacteria (antibiotics, peptides, nitric oxide, ammonium salts, light, etc.) and also resist or release adhesion of bacteria (hydrophilic polymers, zwitterionic, antiadhesive, topography, bioinspired surfaces, etc.). This review aims to outline the progress made in the field of biomedical engineering and biomaterials for the development of multifunctional antibacterial biomedical devices. Additionally, principles for material design and fabrication are highlighted using characteristic examples, with a special focus on combinational nitric oxide-releasing biomedical interfaces. A brief perspective on future research directions for engineering of dual-function antibacterial surfaces is also presented.

show abstract

Custom‐Design of Multi‐Stimuli‐Responsive Degradable Silica Nanoparticles for Advanced Cancer‐Specific Chemotherapy

Zhang,

Zhou,

Tang

et al. 2024

Small

View full text Add to dashboard Cite

Chemotherapy is crucial in oncology for combating malignant tumors but often encounters obatacles such as severe adverse effects, drug resistance, and biocompatibility issues. The advantages of degradable silica nanoparticles in tumor diagnosis and treatment lie in their ability to target drug delivery, minimizing toxicity to normal tissues while enhancing therapeutic efficacy. Moreover, their responsiveness to both endogenous and exogenous stimuli opens up new possibilities for integrating multiple treatment modalities. This review scrutinizes the burgeoning utility of degradable silica nanoparticles in combination with chemotherapy and other treatment modalities. Commencing the elucidation of degradable silica synthesis and degradation mechanisms, emphasis is placed on the responsiveness of these materials to endogenous (e.g., pH, redox reactions, hypoxia, and enzymes) and exogenous stimuli (e.g., light and high‐intensity focused ultrasound). Moreover, this exploration delves into strategies harnessing degradable silica nanoparticles in chemotherapy alone, coupled with radiotherapy, photothermal therapy, photodynamic therapy, gas therapy, immunotherapy, starvation therapy, and chemodynamic therapy, elucidating multimodal synergies. Concluding with an assessment of advances, challenges, and constraints in oncology, despite hurdles, future investigations are anticipated to augment the role of degradable silica in cancer therapy. These insights can serve as a compass for devising more efficacious combined tumor treatment strategies.

show abstract

Multifunctional mesoporous silica nanoparticles for pH-response and photothermy enhanced osteosarcoma therapy

Cited by 9 publications

References 44 publications

Nanocore–Shell Bone Filler Contained Mesoporous Silica Modified with Hydroxyapatite Precursors; Wrapped in a Natural Metal–Phenolic Network

Nanocore–Shell Bone Filler Contained Mesoporous Silica Modified with Hydroxyapatite Precursors; Wrapped in a Natural Metal–Phenolic Network

Recent Developments in Multifunctional Antimicrobial Surfaces and Applications toward Advanced Nitric Oxide-Based Biomaterials

Custom‐Design of Multi‐Stimuli‐Responsive Degradable Silica Nanoparticles for Advanced Cancer‐Specific Chemotherapy

Contact Info

Product

Resources

About