Multifunctional mesoporous bioactive glasses for effective delivery of therapeutic ions and drug/growth factors

Wu, Chengtie; Chang, Jiang

doi:10.1016/j.jconrel.2014.04.026

Cited by 328 publications

(231 citation statements)

References 112 publications

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“…Similar compositions were made into porous scaffolds by Miguez-Pacheco et al using foam replica techniques [10,11]. Lithium has also been incorporated into ordered mesoporous sol-gel glass scaffolds (Li-MBG, 80 mol% SiO 2 ; 10 mol% CaO, 5 mol% P 2 O 5 and 5 mol% Li 2 O) [12][13][14]. The release of lithium from Li-MBG had a beneficial effect on the proliferation and cementogenic differentiation of human periodontal ligament-derived cells via the activation of Wnt and SHH signalling pathways.…”

Section: Introductionmentioning

confidence: 99%

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

Maçon

Jacquemin

Page

et al. 2016

J Sol-Gel Sci Technol

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This work reports the synthesis of lithium-silicate glass, containing 10 mol% of Li 2 O by the sol-gel process, intended for the regeneration of cartilage. Lithium citrate and lithium nitrate were selected as lithium precursors. The effects of the lithium precursor on the sol-gel process, and the resulting glass structure, morphology, dissolution behaviour, chondrocyte viability and proliferation, were investigated. When lithium citrate was used, mesoporous glass containing lithium as a network modifier was obtained, whereas the use of lithium nitrate produced relatively dense glass-ceramic with the presence of lithium metasilicate, as shown by X-ray diffraction, 29 Si and 7 Li MAS NMR and nitrogen sorption data. Nitrate has a better affinity for lithium than citrate, leading to heterogeneous crystallisation from the mesopores, where lithium salts precipitated during drying. Citrate decomposed at a lower temperature, where the crystallisation of lithium-silicate crystal is not thermodynamically favourable. Upon decomposition of the citrate, a solid-state salt metathesis reaction between citrate and silanol occurred, followed by the diffusion of lithium within the structure of the glass. Both glass and glass-ceramic released silica and lithium ions in culture media, but release rate was lower for the glass-ceramic. Both samples did not affect chondrocyte viability and proliferation.Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

Maçon

Jacquemin

Page

et al. 2016

J Sol-Gel Sci Technol

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“…On the other hand, because MBGs are glasses they do not exhibit an exact composition and can be substituted with small amounts of extra oxides of cations featuring important biological actions, such as osteogenesis, antibacterial capacity, angiogenesis or cementogenesis [11][12][13]. For this reason, there is a general trend to upgrade properties with some of the well known therapeutical ions because of their biological action [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Glasses in bone regeneration: A multiscale issue

Salinas

Vallet‐Regí

2016

Journal of Non-Crystalline Solids

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Highligths MBGs containing small amounts of Ga, Ce or Zn exhibit high in vitro bioactivity  The bioactive response is preserved after obtaining 3D scaffolds  These scaffolds are optimum candidates for bone tissue engineering applications  MBG scaffold with 4% ZnO exhibit bactericide action against S. Aureus  The effects of the extra ions is sometimes complex and needs to be investigated 2 Abstract 3D scaffolds based in mesoporous bioactive glasses (MBGs) are being widely investigated to use in bone tissue engineering (TE) applications. These scaffolds are often obtained by rapid prototyping (RP) and exhibit an array of interconnected pores in a hierarchy of sizes. The ordered mesopores network (around 4 nm in diameter), is optimal for the adsorption and release of bone inductor biomolecules, and the arrangement of macropores over 100 m facilitates the bone cell ingrowths and angiogenesis. Nevertheless MBGs composition can be varied almost infinitely at the atomic scale by including in the glass network oxides of inorganic elements with a therapeutic action. In this article the synthesis and characterization of MBG scaffolds based on the 80%SiO2-15%CaO-5%P2O5 (in mol-%) glass with substitutions up to 3.5% of Ga2O3 or Ce2O3 or 7.0% of ZnO is revisited. The substituent inclusion and the RP processing slightly decrease the surface area, the pore volume and the mesoporous order as well as their bioactive response in solutions mimicking blood plasma. However, these values still remain useful for bone TE applications. Results exhibiting the bactericide action of MBG scaffolds containing ZnO are also presented. KeywordsMesoporous bioactive glass scaffolds; Ga, Ce and Zn as therapeutical ions; bactericide capability; bone tissue engineering 3

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“…5 A growing number of publications have shown experimental evidence about the biological effects of the ionic dissolution products released from bioceramic materials. [6][7][8][9][10] Within this context, it is important to mention the progress made with bioactive glasses (BGs). 6,[8][9][10] The most widely used BGs are amorphous solids based on a silicate matrix.…”

Section: Introductionmentioning

confidence: 99%

Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass

et al. 2015

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In regenerative medicine of vascularized tissues, there is a great interest in the use of biomaterials that are able to stimulate angiogenesis, a process necessary for rapid revascularization to allow the transport and exchange of oxygen, nutrients, growth factors and cells that take part in tissue repair and/or regeneration. An increasing number of publications have shown that bioactive glasses stimulate angiogenesis. Because it has been established that boron (B) may play a role in angiogenesis, the aim of this study was to assess the in vivo angiogenic effects of the ionic dissolution products that from a bioactive glass (BG) in the 45S5 system doped with 2 wt% B 2 O 3 (45S5.2B). The pro-angiogenic capacity of 45S5.2B BG was assessed on the vasculature of the embryonic quail chorioallantoic membrane (CAM).Ionic dissolution products from 45S5.2B BG increased angiogenesis. This is quantitatively evidenced by the greater expression of integrin a v b 3 and higher vascular density in the embryonic quail CAM. The response observed at 2 and 5 days post-treatment was equivalent to that achieved by applying 10 mg mL À1 of basic fibroblast growth factor. These results show that the ionic dissolution products released from the bioactive glass 45S5.2B stimulate angiogenesis in vivo. The effects observed are attributed to the presence the ionic dissolution products, which contained 160 AE 10 mM borate.

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Multifunctional mesoporous bioactive glasses for effective delivery of therapeutic ions and drug/growth factors

Cited by 328 publications

References 112 publications

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

Glasses in bone regeneration: A multiscale issue

Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass

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