Multifunctional Medicated Lyophilised Wafer Dressing for Effective Chronic Wound Healing

Pawar, Harshavardhan; Boateng, Joshua; Ayensu, Isaac; Tetteh, John

doi:10.1002/jps.23968

Cited by 77 publications

(59 citation statements)

References 31 publications

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“…On the other hand, wafers have been employed as wound healing [16] and buccal [18] drug delivery systems. They can therefore be employed in the delivery of NIC, including composite systems combining two or more polymers [16,17] as demonstrated by Pawar and co-workers [18,19] who reported the use of composite polymeric wafers combining polyox with either carrageenan or sodium alginate in the development of wafers for controlled delivery of drugs to chronic wound sites [18,19].…”

Section: Introductionmentioning

confidence: 99%

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Okeke

Boateng

2016

International Journal of Biological Macromolecules

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Smoking cessation is of current topical interest due to the significant negative health and economic impact in many countries. This study aimed to develop buccal films and wafers comprising HPMC and sodium alginate (SA) for potential use in nicotine replacement therapy via the buccal mucosa, as a cheap but effective alternative to currently used nicotine patch and chewing gum. The formulations were characterised using texture analyser (tensile and hardness, mucoadhesion), scanning electron microscopy, x-ray diffractometry, attenuated total reflection -Fourier transform infrared (ATR-FTIR), differential scanning calorimetry (DSC) and swelling capacity. Drug loaded films and wafers were characterised for content uniformity (HPLC) whilst the drug loaded wafers only were further characterised for in vitro drug dissolution. SA modified and improved the functional properties of HPMC at optimum ratio of HPMC: SA of 1.25 : 0.75. Generally, both films and wafers (blank and drug loaded) were amorphous in nature which impacted on swelling and mucoadhesive performance.HPMC-SA composite wafers showed a porous internal morphology with higher mucoadhesion, swelling index and drug loading capacity compared to the HPMC-SA composite films which were non-porous. The study demonstrates the potential use of composite HPMC-SA wafers in the buccal delivery nicotine.

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Section: Introductionmentioning

confidence: 99%

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Okeke

Boateng

2016

International Journal of Biological Macromolecules

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“…These include polymers containing strong H-bonding groups, strong anionic charges, high molecular weight, sufficient chain flexibility, and surface energy properties which favour spreading of the polymer onto the mucosal surface 11 . For the purpose of wound dressings, adhesive properties of the polymers could be affected by degree of hydration, amount of exudate released from the wound, exudate viscosity, salts and proteins present in exudate, presence of microorganisms as well as the depth and area of the wound 12 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in vitro wound adhesion characteristics of composite film and wafer based dressings using texture analysis and FTIR spectroscopy: a chemometrics factor analysis approach

Boateng

Pawar

2015

RSC Adv.

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The adhesive properties of two dressing types, solvent cast films and freeze-dried wafers have been determined and compared using two analytical techniques, combined with chemometrics data analysis. Films and wafers were prepared from gels containing polyox (POL) combined with carrageenan (CAR) or sodium alginate (SA), glycerol (GLY) as plasticiser (films) with streptomycin and diclofenac as model drugs. The gels were dried in an oven at 40°C or freeze-dried to obtain films and wafers respectively. The adhesive performance of the films and wafers was assessed with 6.67% w/v gel using a texture analyser to measure the stickiness, work of adhesion and cohesiveness. The effect of viscosity of simulated wound fluid[(containing (2% w/w or 5% w/w bovine serum albumin)] and mucin solution (2% w/w) present on the gelatin surface on texture analyser profiles was investigated. Furthermore, the adhesive properties were estimated and evaluated using attenuated total reflectance Fourier transform infrared spectroscopy by monitoring the diffusion of mucin solution [2% w/w in phosphate buffered saline (PBS) pH 7.4] through the formulations. The diffusion data was analysed using target factor analysis (chemometrics approach) to establish proof of concept for predicting adhesion by measuring mucin interaction and its diffusion through films and wafers. There was a significant effect of simulated wound fluid, viscosity, plasticizer (for films) and drug loading on the adhesive performance of both films and wafers. POL-SA films showed higher mucoadhesive performance in the presence of viscous simulated wound fluid containing 5% bovine serum albumin. Wafers and plasticised films demonstrated high detachment force indicating strong interactions between the chains of the polymers (POL, SA and CAR) and the model wound surface (gelatin). ATR-FTIR spectroscopy showed that mucin diffused independently through the solvent and across the films and wafers. POL-CAR films generally showed slower diffusion of mucin when compared with POL-SA films whilst the opposite effect was observed for diffusion through POL-CAR wafers and POL-SA wafers. Generally, diffusion through wafers was faster than the corresponding films.

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“…Due to their highly porous nature, they can absorb high amounts of exudate rapidly which improves wound healing. Wafers can carry both antibacterial and anti-inlammatory drugs at the same time which give dual efects of inhibiting bacteria and reducing inlammation [44]. Wafers have good adhesion and difusion properties [45] while Labovitiadi et al [46] reported that wafers are a compatible delivery system for both insoluble and soluble antimicrobial drugs that exhibit beter antimicrobial activity.…”

Section: Wound Dressingsmentioning

confidence: 99%

Antimicrobial Dressings for Improving Wound Healing

Sarheed¹,

Ahmed²,

Shouqair³

et al. 2016

Wound Healing - New Insights Into Ancient Challenges

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Wound healing occurs by a series of interrelated molecular events which work together to restore tissue integrity and cellular function. These physiological events occur smoothly in normal healthy individual and/or under normal conditions. However, in certain cases, these molecular events are retarded resulting in hard-to-heal or chronic wounds arising from several factors such as poor venous return, underlying physiological or metabolic conditions such as diabetes as well as external factors such as poor nutrition. In most cases, such wounds are infected and infection also presents as another complicating phenomenon which triggers inlammatory reactions, therefore delaying wound healing. There has therefore been recent interests and signiicant eforts in preventing and actively treating wound infections by directly targeting infection causative agents through direct application of antimicrobial agents either alone or loaded into dressings (medicated). These have the advantage of overcoming challenges such as poor circulation in diabetic and leg ulcers when administered systemically and also require lower amounts to be applied compared to that required via oral or iv administration. This chapter will review and evaluate various antimicrobial agents used to target infected wounds, the means of delivery, and current state of the art, including commercially available dressings. Data sources will include mainly peer-reviewed literature, clinical trials and reports, patents as well as government reports where available.

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Multifunctional Medicated Lyophilised Wafer Dressing for Effective Chronic Wound Healing

Cited by 77 publications

References 31 publications

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Evaluation of in vitro wound adhesion characteristics of composite film and wafer based dressings using texture analysis and FTIR spectroscopy: a chemometrics factor analysis approach

Antimicrobial Dressings for Improving Wound Healing

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