Multifunctional manganese-doped Prussian blue nanoparticles for two-photon photothermal therapy and magnetic resonance imaging

The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment

“…In the small metal ion-doped PBNPs, the metal ions should be located at the surface, making these metal ions sites particularly accessible to water and this increases the number of bound water molecules. Ali et al synthesized different sizes of Mn 2+ -doped PBNPs and revealed that the r 1 value was equal to 2.58 and 5.30 mM −1 s −1 for sizes of 73 nm and 61 nm, respectively [37]. (3) Testing temperature: according to SBM, the r 1 value increased as the temperature decreased because of the increase in the rotational correlation time.…”

“…It is reported that PBNPs were demonstrated as an effective T 1 -weighted cellular MRI contrast agent in 2010 [32], but it is approximately an order of magnitude lower than clinical T 1 -weighted MRICAs due to their poor ordinary longitudinal relaxivity. So, promoted their diagnostic capability by achieving a larger r 1 with a smaller amount of injected PBNPs metallic ions has become a topic of intense research interest in recent years [33][34][35][36][37][38]. The PBNPs with a blue appearance can cause transient thermoelastic expansion via strong NIR absorption and provide ultrasonic signals for PAI [39], and modified PBNPs have better photothermal stability and photoacoustic signal-to-noise ratio [40].…”

Enhanced two-photon absorption of ligated silver and gold nanoclusters: theoretical and experimental assessments

“…The absorbed photon energy (light) can be converted into strong localized heat, which may ultimately destroy cancer cells via hyperthermia. This process, called 2-Photon thermal therapy (2PTT) 108 -is somewhat similar to plasmonic photothermal therapy (PPTT), 109 using linear absorption of nanoparticles. It may be interesting to compare the efficiency of both processes to evaluate the added value of using NLO and ligated gold or silver NCs.…”

Synergic effect of doxorubicin release and two-photon irradiation of Mn2+-doped Prussian blue nanoparticles on cancer therapy

“…The Mn 2+ doped PB nanoparticles have been chosen for this study due to their multifunctionality as MRI contrast agents and PTT therapeutic agent, since the presence of Mn 2+ ion in such amount does not impact the PTT efficiency. 24 Mn 6 ] 0.88 @DOX 0.04 1@DOX present typical stretching vibrations of the bridging cyanide group n(Fe II -CN-Fe III ) at 2080 cm À1 in the FTIR spectra, as the pristine nanoparticles 1 with an appearance of small intensity bands ngerprints of DOX in the 800-1500 cm À1 frequency range (Fig. S2, ESI †).…”