Multifunctional magnetic nanoparticles for magnetic resonance image-guided photothermal therapy for cancer

Yue, Xiuli; Ma, Fang; Dai, Zhifei

doi:10.1088/1674-1056/23/4/044301

Cited by 8 publications

(7 citation statements)

References 55 publications

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“…MNPs also enhance proton relaxation of specific tissues, and thereby can be used contrast agents for magnetic resonance imaging (MRI) [32]. Thus, MNPs can serve as a multi-functional platform for cancer therapy, providing simultaneous tumor heating and imaging [1,34]. These unique MNP features further emphasize the potential of our method for enhancing PTT, as targeted MNPs that reach specific tissue can induce cell death independently from that of the non-targeted tissue, via AMF combined with laser.…”

Section: Discussionmentioning

confidence: 99%

“…Photo-thermal therapy (PTT) is a minimally-invasive therapeutic strategy that destroys cancer cells using photon energy converted into heat [1][2][3][4]. One of the main PTT procedures involves dispersion of magnetic particles (MNPs) throughout the target tissue, and subsequent application of an external alternating magnetic field (AMF) of sufficient strength and frequency to induce heating of the particles.…”

Section: Introductionmentioning

confidence: 99%

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Thermal therapy with magnetic nanoparticles for cell destruction

Vegerhof¹,

Motei²,

Rudinzky³

et al. 2016

Biomed. Opt. Express

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Abstract:In this article we suggest a new concept for cell destruction based upon manipulating magnetic nanoparticles (MNPs) by applying external, low frequency alternating magnetic field (AMF) that oscillates the particles, together with focused laser illumination. Assessment of temperature profiles in a head and neck squamous cell carcinoma sample showed that cells with MNPs, treated with AMF (3 Hz, 300 mW) and laser irradiation (30 mW), reached 42°C after 4.5 min, as opposed to cells treated with laser but without AMF. Moreover, a theoretical model was developed to assess the overall theoretical temperature rise, which was shown to be 50% lower than the experimental temperature. Furthermore, we found that the combination of laser irradiation and AMF decreased the number of live cells by ~50%. Thus, the concentrated assembly of laser heating with AMF-induced MNP oscillations leads to more rapid and efficient cell death. These results suggest that the manipulated MNP technique can serve as a superior agent for PTT, with improved cell death capabilities. References and links1. X.-L. Yue, F. Ma, and Z.-F. Dai, "Multifunctional magnetic nanoparticles for magnetic resonance image-guided photothermal therapy for cancer," Chin. Phys. B 23(4), 044301 (2014). 2. X. Huang, I. H. El-Sayed, W. Qian, and M. A. El-Sayed, "Cancer cells assemble and align gold nanorods conjugated to antibodies to produce highly enhanced, sharp, and polarized surface Raman spectra: a potential cancer diagnostic marker," Nano Lett. 7(6), 1591-1597 (2007). Loening, and P. Wust, "Thermotherapy of Prostate Cancer Using Magnetic Nanoparticles: Feasibility, Imaging, and Three-Dimensional Temperature Distribution," Eur. Urol. 52(6), 1653-1662 (2007). 12. T. Roose, "Challenges in imaging and predictive modeling of rhizosphere processes," Plant Soil 407, 9-38 (2016). 13. C. C. Berry, "Progress in functionalization of magnetic nanoparticles for applications in biomedicine," J. Phys. D Appl. Phys. 198, 22 (2009 Motiei, and R. Popovtzer, "A challenge for theranostics: is the optimal particle for therapy also optimal for diagnostics?" Nanoscale 7(37), 15175-15184 (2015). 17. T. Reuveni, M. Motiei, Z. Romman, A. Popovtzer, and R. Popovtzer, "Targeted gold nanoparticles enable molecular CT imaging of cancer: an in vivo study," Int. J. Nanomedicine 6, 2859-2864 (2011). 18. V. Adi, R. Arkady, B. Yevgeny, D. Hamootal, P. Rachel, and Z. Zeev, "manipulated magnetic nano particles for photonic biomedical mapping," Nanosci. Nanotechnol. Lett. 7, 1-9 (2015). stabilized iron oxide magnetic nanoparticles," J. Nanopart. Res. 9(5), 959-964 (2007).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thermal therapy with magnetic nanoparticles for cell destruction

Vegerhof¹,

Motei²,

Rudinzky³

et al. 2016

Biomed. Opt. Express

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“…Imaging guiding is markedly important in PTT since it can offer comprehensive information such as the exact location and size of tumors, the temperature changes of cancerous/normal tissues, as well as the distribution and enrichment of PTAs in the body and tumor sites. [ 29 ] Therefore, multifunctional MNPs with good imaging ability and NIR light‐responsive performance have become a kind of PTAs with high performance, which can achieve MRI‐, MPI‐, and multimodal imaging‐guided PTT. [ 30‐31 ] Before systemically describing their imaging‐guided strategies, we first introduce the common optical windows used in PTT.…”

Section: Multifunctional Mnps For Imaging‐guided Cancer Therapymentioning

confidence: 99%

Imaging‐Guided Cancer Therapy Based on Multifunctional Magnetic Nanoparticles^†

Hou

Wang

2023

Chin. J. Chem.

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Comprehensive SummaryIn recent years, magnetic nanoparticles (MNPs) have received great attention within the field of biomedicine, especially for cancer therapy. This is because MNPs have many excellent physical and chemical properties to provide sufficient imaging information along with satisfactory therapeutic efficacy. Moreover, by virtue of various modification strategies, the obtained multifunctional MNPs can further achieve synergized multimodal cancer theranostic, which is worthy of further study. In this review, we summarize the recent developments in imaging‐guided strategies and synergistic cancer therapy based on multifunctional MNPs. Then, we discuss the challenge and perspective of the next generation of MNPs‐based imaging‐guided cancer therapy, hoping to provide guidance in potential applications.

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“…The last decades have witnessed a continuous growth in the use of single-shot MRI, both for clinical and research applications. [1][2][3][4][5][6][7][8] Owing to the good temporal resolution, these single-shot MRI methods are referred to as "ultrafast" imaging protocols. These "ultrafast" protocols play an essential role in experiments and researches demanding high temporal resolution.…”

Section: Introductionmentioning

confidence: 99%

Flexible reduced field of view magnetic resonance imaging based on single-shot spatiotemporally encoded technique

Cai

Chen

et al. 2015

Chinese Phys. B

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In many ultrafast imaging applications, the reduced field-of-view (rFOV) technique is often used to enhance the spatial resolution and field inhomogeneity immunity of the images. The stationary-phase characteristic of the spatiotemporally-encoded (SPEN) method offers an inherent applicability to rFOV imaging. In this study, a flexible rFOV imaging method is presented and the superiority of the SPEN approach in rFOV imaging is demonstrated. The proposed method is validated with phantom and in vivo rat experiments, including cardiac imaging and contrast-enhanced perfusion imaging. For comparison, the echo planar imaging (EPI) experiments with orthogonal RF excitation are also performed. The results show that the signal-to-noise ratios of the images acquired by the proposed method can be higher than those obtained with the rFOV EPI. Moreover, the proposed method shows better performance in the cardiac imaging and perfusion imaging of rat kidney, and it can scan one or more regions of interest (ROIs) with high spatial resolution in a single shot. It might be a favorable solution to ultrafast imaging applications in cases with severe susceptibility heterogeneities, such as cardiac imaging and perfusion imaging. Furthermore, it might be promising in applications with separate ROIs, such as mammary and limb imaging.

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Multifunctional magnetic nanoparticles for magnetic resonance image-guided photothermal therapy for cancer

Cited by 8 publications

References 55 publications

Thermal therapy with magnetic nanoparticles for cell destruction

Thermal therapy with magnetic nanoparticles for cell destruction

Imaging‐Guided Cancer Therapy Based on Multifunctional Magnetic Nanoparticles^†

Flexible reduced field of view magnetic resonance imaging based on single-shot spatiotemporally encoded technique

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Multifunctional magnetic nanoparticles for magnetic resonance image-guided photothermal therapy for cancer

Cited by 8 publications

References 55 publications

Thermal therapy with magnetic nanoparticles for cell destruction

Thermal therapy with magnetic nanoparticles for cell destruction

Imaging‐Guided Cancer Therapy Based on Multifunctional Magnetic Nanoparticles†

Flexible reduced field of view magnetic resonance imaging based on single-shot spatiotemporally encoded technique

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Product

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Imaging‐Guided Cancer Therapy Based on Multifunctional Magnetic Nanoparticles^†