Multifunctional magnetic-gold nanoparticles for efficient combined targeted drug delivery and interstitial photothermal therapy

Elbialy, Nihal Saad; Fathy, Mohamed; Al-Wafi, Reem; Darwesh, Reem; Abdel-dayem, Umama A.; Aldhahri, Musab; Noorwali, Abdulwahab; Alghamdi, Abdullah

doi:10.1016/j.ijpharm.2018.11.021

Cited by 53 publications

(25 citation statements)

References 28 publications

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“…Other forms of colloidal gold are also useful for cancer therapeutics. Elbialy et al have developed magnetic gold nanoparticles (MGNPs) that can be targeted to the tumor region using an applied magnetic field [49]. In the work, they loaded DOX into the nanostructures for selective delivery of chemotherapy to the targeted region.…”

Section: Nanomaterials As Targeted Drug-delivery Vehiclesmentioning

confidence: 99%

Nanomaterial Applications in Photothermal Therapy for Cancer

et al. 2019

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As a result of their unique compositions and properties, nanomaterials have recently seen a tremendous increase in use for novel cancer therapies. By taking advantage of the optical absorption of near-infrared light, researchers have utilized nanostructures such as carbon nanotubes, gold nanorods, and graphene oxide sheets to enhance photothermal therapies and target the effect on the tumor tissue. However, new uses for nanomaterials in targeted cancer therapy are coming to light, and the efficacy of photothermal therapy has increased dramatically. In this work, we review some of the current applications of nanomaterials to enhance photothermal therapy, specifically as photothermal absorbers, drug delivery vehicles, photoimmunological agents, and theranostic tools.

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Section: Nanomaterials As Targeted Drug-delivery Vehiclesmentioning

confidence: 99%

Nanomaterial Applications in Photothermal Therapy for Cancer

et al. 2019

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“…However, applications of gold clusters for therapeutic hyperthermia under alternative magnetic force exposure have not been developed yet [62]. On the other hand, alloy iron oxide-gold nanoparticles have been investigated as contrast agents for MRI by exploiting the magnetic properties of iron oxide [63][64][65][66][67]. Magnetic alloy AuNMs and their biomedical applications have been comprehensively described in a recent review [68].…”

Section: Laser Lightmentioning

confidence: 99%

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

Movia

Benhaddada

Spadavecchia

et al. 2020

Precision Nanomedicine

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Graphical abstract KeywordsGold nanoparticle 1 ; external stimuli; physical stimuli; physically triggered nanomedicine. Quote this article as: Movia D, Benhaddada M, Jolanda Spadavecchia J, Prina-Mello A, Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies, Precis. Nanomed. 2020 April;3(2):495-524, https://doi. AbstractNanomedicine aims at enhancing treatment efficiency and/or improving diagnostic sensitivity by better controlling several critical parameters, such as tissue targeting and off-target toxicity. More recently, advanced nanomedicine products have been developed to achieve spatially and temporally controlled therapy and diagnosis. This review focuses on gold nanomaterials (AuNMs) and alloy/hybrid AuNMs that can be used in stimuli-responsive strategies for therapeutic and diagnostic applications. Endogenous and/or exogenous stimuli can be used as a trigger for such systems. Herein, we focus on those activated by exogenous stimuli. Our review starts from one specific externally activated product, Aurolase®, which recently underwent clinical studies. Further we continue describing a specific physically triggered category, for which the exogeneous stimulus applied induces a structural transformation or modification that is essential for their therapeutic and/or diagnostic action. Gold nanomaterials are grouped both by the nature of the function they exert (therapeutic or diagnostic) and the stimuli class.

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“…Metal nanoparticles (such as Au, Ag, and Fe) with easy surface functionalization have emerged as a major nanoplatform with important applications, such as biosensing and drug delivery, due to their distinctive biological properties. For example, the excellent properties of biofunctionalized Au nanoparticles have evoked strong interest in drug delivery and bioimaging . Although some metal nanoparticles have distinct characteristics compared to equivalent materials, they do not have suitable surface properties for certain applications.…”

Section: Biomedical Materials Based On Cysteine and Its Derivativesmentioning

confidence: 99%

Cysteine‐Based Biomaterials as Drug Nanocarriers

Meng

Han

et al. 2019

Advanced Therapeutics

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In the past decade, a variety of cysteine-based multifunctional biomaterials has been successfully developed for drug delivery and proven invaluable in campaigns against human disease. Despite several significant achievements, a systematic investigation of the structure-property relationships in the field of drug delivery has not been performed. In this review, a variety of up-to-date literature results are discussed and compiled in which cysteine and its derivatives have been used in the preparation of payload delivery systems for the treatment of human disease. Particular emphasis is placed on the synthesis methods, especially the structure-property relationship for drug delivery and disease therapy. Additionally, this review focuses on recent innovations in redox-responsive nanocarriers based on cysteine and its derivatives for in vivo drug delivery to achieve a better therapeutic effect. In summary, nanocarriers based on cysteine and its derivatives have the potential to enhance the efficiency of human disease therapy without increasing toxicity.

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Multifunctional magnetic-gold nanoparticles for efficient combined targeted drug delivery and interstitial photothermal therapy

Cited by 53 publications

References 28 publications

Nanomaterial Applications in Photothermal Therapy for Cancer

Nanomaterial Applications in Photothermal Therapy for Cancer

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

Cysteine‐Based Biomaterials as Drug Nanocarriers

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