Multifunctional Magnetic Gold Nanocomposites: Human Epithelial Cancer Detection via Magnetic Resonance Imaging and Localized Synchronous Therapy

Abstract

Novel multifunctional magnetic gold nanocomposites (MGNCs) were synthesized for synchronous cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MGNCs consist of magnetic kernels (aggregates of ultra‐sensitive MnFe2O4 magnetic nanocrystals wrapped in polymer) as effective MR contrast agents and silica–gold nanocomposites as hyperthermal therapeutic agents. A therapeutic antibody, Erbitux (ERB), was conjugated for specific tumor cell targeting both to localize the near‐IR laser beam and to image their events through MRI. ERB‐conjugated MGNCs selectively recognize the target cancer cell lines. Fluorescence images and MRI analysis show that the MGNCs are effectively taken up by the cells. ERB‐conjugated MGNCs have an excellent synchronous therapeutic efficacy as a result of the therapeutic antibody and near‐IR laser‐induced surface plasmon resonance. Consequently, MGNCs clearly demonstrate selective imaging and treatment of human epithelial cancer simultaneously.

The characteristic AgcoreAushell nanoparticles as SERS substrates in detecting dopamine molecules at various pH ranges

“…[4][5][6] The plasmonic core-shell NPs can also have a strong absorption in the near-infrared region, which can lead to a photothermal effect, consequently interplaying as a theranostic particle system with diagnostic and therapeutic capability. [7][8][9] Surface-enhanced Raman scattering (SERS) is a promising and highly sensitive and selective optical analysis technique. 10,11 It can markedly enhance the Raman signals of probe molecules by a factor of 10 6 -10 14 , thus enabling the detection even of a single molecule.…”

One-step deposition of Au nanoparticles onto chemically modified ceramic hollow spheres via self-assembly

“…Apart from Au-'Si' composites, the preparation of multifunctional Au-'Si'-Fe composite spheres has also received more attention [30][31][32][33][34][35][36][37]. Au-'Si'-Fe composite spheres are useful as magnetic drug delivery vectors or catalyst supports [32].…”

“…Au-'Si'-Fe composite spheres are useful as magnetic drug delivery vectors or catalyst supports [32]. These type of structures can be built layer-by-layer (LBL) [33][34][35][36], or by covering the 'Si' surface with a single layer made up of Au and iron oxide [30,31]. The LBL approach involves coating the iron oxide-based magnetic NPs with a layer of either 'Si', followed by an over coat of Au NPs [34][35][36], or Au-'Si' core-shell NPs [33].…”

“…These type of structures can be built layer-by-layer (LBL) [33][34][35][36], or by covering the 'Si' surface with a single layer made up of Au and iron oxide [30,31]. The LBL approach involves coating the iron oxide-based magnetic NPs with a layer of either 'Si', followed by an over coat of Au NPs [34][35][36], or Au-'Si' core-shell NPs [33]. The Au layer may adsorb by seeded growth [31,34,35], or direct deposition of Au NPs [30].…”

“…The LBL approach involves coating the iron oxide-based magnetic NPs with a layer of either 'Si', followed by an over coat of Au NPs [34][35][36], or Au-'Si' core-shell NPs [33]. The Au layer may adsorb by seeded growth [31,34,35], or direct deposition of Au NPs [30].…”