Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools

Materia, María Elena; Leal, Manuel Pernía; Scotto, Marco; Balakrishnan, Preethi Bala; Avugadda, Sahitya Kumar; García-Martín, María Luisa; Cohen, Bruce E.; Chan, Emory M.; Pellegrino, Teresa

doi:10.1021/acs.bioconjchem.7b00432

Cited by 15 publications

(11 citation statements)

References 36 publications

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“…The proton relaxation rates of the Si, Di/tri, 3D-Clusters, and 2D-Clusters samples were analyzed using a Minispec spectrometer (Bruker, Germany, mq60, (1.5 T)) [ 28 , 31 ]. The samples were diluted to obtain aqueous nanoparticle suspension series containing an iron concentration ranged from 0.009 mM to 0.6 mM.…”

Section: Methodsmentioning

confidence: 99%

Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters

et al. 2020

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Multifunctional imaging nanoprobes continue to garner strong interest for their great potential in the detection and monitoring of cancer. In this study, we investigate a series of spatially arranged iron oxide nanocube-based clusters (i.e., chain-like dimer/trimer, centrosymmetric clusters, and enzymatically cleavable two-dimensional clusters) as magnetic particle imaging and magnetic resonance imaging probes. Our findings demonstrate that the short nanocube chain assemblies exhibit remarkable magnetic particle imaging signal enhancement with respect to the individually dispersed or the centrosymmetric cluster analogues. This result can be attributed to the beneficial uniaxial magnetic dipolar coupling occurring in the chain-like nanocube assembly. Moreover, we could effectively synthesize enzymatically cleavable two-dimensional nanocube clusters, which upon exposure to a lytic enzyme, exhibit a progressive increase in magnetic particle imaging signal at well-defined incubation time points. The increase in magnetic particle imaging signal can be used to trace the disassembly of the large planar clusters into smaller nanocube chains by enzymatic polymer degradation. These studies demonstrate that chain-like assemblies of iron oxide nanocubes offer the best spatial arrangement to improve magnetic particle imaging signals. In addition, the nanocube clusters synthesized in this study also show remarkable transverse magnetic resonance imaging relaxation signals. These nanoprobes, previously showcased for their outstanding heat performance in magnetic hyperthermia applications, have great potential as dual imaging probes and could be employed to improve the tumor thermo-therapeutic efficacy, while offering a readable magnetic signal for image mapping of material disassemblies at tumor sites.

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Section: Methodsmentioning

confidence: 99%

Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters

et al. 2020

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“…Examples include silica NPs with embedded QDs, Au NCs, , or both QDs and IONPs . Polymer NPs have been doped with UCNPs and a mix of UCNPs and IONPs …”

Section: Catalog Of Materialsmentioning

confidence: 99%

“…543 Polymer NPs have been doped with UCNPs 544 and a mix of UCNPs and IONPs. 545 A related morphology is a super-NP assembly, which is a colloid made up of many copies of an LNP or many copies of an LNP plus many copies of another NP material, often with colloidally stabilizing surface chemistry. Most of the particle volume consists of LNPs and any other functional NPs rather than a carrier matrix.…”

Section: Multi-nanoparticle Assembliesmentioning

confidence: 99%

Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging

et al. 2021

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Research related to the development and application of luminescent nanoparticles (LNPs) for chemical and biological analysis and imaging is flourishing. Novel materials and new applications continue to be reported after two decades of research. This review provides a comprehensive and heuristic overview of this field. It is targeted to both newcomers and experts who are interested in a critical assessment of LNP materials, their properties, strengths and weaknesses, and prospective applications. Numerous LNP materials are cataloged by fundamental descriptions of their chemical identities and physical morphology, quantitative photoluminescence (PL) properties, PL mechanisms, and surface chemistry. These materials include various semiconductor quantum dots, carbon nanotubes, graphene derivatives, carbon dots, nanodiamonds, luminescent metal nanoclusters, lanthanidedoped upconversion nanoparticles and downshifting nanoparticles, triplet−triplet annihilation nanoparticles, persistent-luminescence nanoparticles, conjugated polymer nanoparticles and semiconducting polymer dots, multi-nanoparticle assemblies, and doped and labeled nanoparticles, including but not limited to those based on polymers and silica. As an exercise in the critical assessment of LNP properties, these materials are ranked by several application-related functional criteria. Additional sections highlight recent examples of advances in chemical and biological analysis, point-of-care diagnostics, and cellular, tissue, and in vivo imaging and theranostics. These examples are drawn from the recent literature and organized by both LNP material and the particular properties that are leveraged to an advantage. Finally, a perspective on what comes next for the field is offered.

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“…Since the broad size distribution of agarose bead (45-165 mm) is a limiting factor for ow cytometry, the use of bead with uniform size (1 mm) with magnetic property is a desirable option because of low auto uorescence background, higher sensitivity, and easy separation of bound protein. 28 To investigate such a performance, Ni-NTA magnetic beads combined with ht-GFP was analysed using ow cytometry (Fig. S3 †).…”

Section: Flow Cytometry For Ht-gfp Quanticationmentioning

confidence: 99%