Multifunctional magnesium organic framework-based photothermal and pH dual-responsive mouthguard for caries prevention and tooth self-healing promotion

Li, Qun; Liu, Jinbiao; Liu, Huijie; Sun, Yue; Xu, Yingying; Wang, Kexin; Huang, Weixin; Lan, Lei; Wang, Xiaolei

doi:10.1016/j.bioactmat.2023.06.017

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…There have been tremendous progress in the prevention and treatment of dental caries, such as the development of pHresponsive materials to release photosensitizers 7,8 and the application of biomimetic mineralization mediated by amyloid or collagen fibrils. 9,10 Photothermal therapy (PTT) is a highly promising strategy to control dental infection, and its effectiveness can be enhanced by reactive oxygen species, 11 acoustic power, 12 and antimicrobial ions or drugs.…”

Section: ■ Introductionmentioning

confidence: 99%

“…There have been tremendous progress in the prevention and treatment of dental caries, such as the development of pH-responsive materials to release photosensitizers , and the application of biomimetic mineralization mediated by amyloid or collagen fibrils. , Photothermal therapy (PTT) is a highly promising strategy to control dental infection, and its effectiveness can be enhanced by reactive oxygen species, acoustic power, and antimicrobial ions or drugs. − Among these methods, Ag nanoparticle-assisted PTT attracts our interests. For example, Ma et al and Qi et al separately developed efficient PTT bactericidal platforms utilizing Ag nanoparticle-decorated PB nanocubes and polydopamine nanospheres.…”

Section: Introductionmentioning

confidence: 99%

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Dental Caries Management with Antibacterial Silver-Doped Prussian Blue Hydrogel by the Combined Effects of Photothermal Response and Ion Discharge

Li,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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Caries is a destructive condition caused by bacterial infection that affects the hard tissues of the teeth, significantly reducing the quality of life for individuals. Photothermal therapy (PTT) offers a noninvasive and painless treatment for caries, but the use of unsafe laser irradiance limits its application. To address this challenge, we prepared nanoparticles of silver ion-doped Prussian blue (AgPB), which was encased within cationic guar gum (CG) to form the antibacterial PTT hydrogel CG-AgPB with a photothermal conversion efficiency of 34.4%. When exposed to an 808 nm laser at a power density of 0.4 W/cm2, the hydrogel readily reached a temperature of over 50 °C in just 3 min, synchronized by the discharge of Ag+ ions from the interstitial sites of AgPB crystals, resulting in broad-spectrum and synergistic antibacterial activities (>99%) against individual oral pathogens (Streptococcus sanguinis, Streptococcus mutans, and Streptococcus sobrinus) and pathogen-induced biofilms. In vivo, CG-AgPB-mediated PTT demonstrated a capability to profoundly reduce the terminal number of cariogenic bacteria to below 1% in a rat model of caries. Given the outstanding biocompatibility, injectability, and flushability, this CG-AgPB hydrogel may hold promise as a next-generation oral hygiene adjunct for caries management in a clinical setting.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dental Caries Management with Antibacterial Silver-Doped Prussian Blue Hydrogel by the Combined Effects of Photothermal Response and Ion Discharge

Li,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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“…Studies have shown that metal-organic frameworks formed by the coordination of metal ions with organic ligands can gradually release metal ions in response to acid conditions, making them ideal candidates for metal ions storage and delivery [ 15 , 16 ]. Theoretically, magnesium organic framework (Mg-MOF) can be delivered to bone tissue and gradually release Mg 2+ in response to the acidic microenvironment of osteoporosis, which has the potential to improve the bone microenvironment and promote bone regeneration [ 17 , 18 ]. It is worth noting that when osteoporosis occurs, there is already a severe calcium deficiency in the bone tissue, and the anti-osteoporosis effect of only magnesium supplementation is limited [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy

Weng,

Ye,

Cai

et al. 2024

J Nanobiotechnol

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Osteoporosis is the most common bone metabolic disease that affects the health of middle-aged and elderly people, which is hallmarked by imbalanced bone remodeling and a deteriorating immune microenvironment. Magnesium and calcium are pivotal matrix components that participate in the bone formation process, especially in the immune microenvironment regulation and bone remodeling stages. Nevertheless, how to potently deliver magnesium and calcium to bone tissue remains a challenge. Here, we have constructed a multifunctional nanoplatform composed of calcium-based upconversion nanoparticles and magnesium organic frameworks (CM-NH2-PAA-Ald, denoted as CMPA), which features bone-targeting and pH-responsive properties, effectively regulating the inflammatory microenvironment and promoting the coordination of osteogenic functions for treating osteoporosis. The nanoplatform can efficaciously target bone tissue and gradually degrade in response to the acidic microenvironment of osteoporosis to release magnesium and calcium ions. This study validates that CMPA possessing favorable biocompatibility can suppress inflammation and facilitate osteogenesis to treat osteoporosis. Importantly, high-throughput sequencing results demonstrate that the nanoplatform exerts a good inflammatory regulation effect through inhibition of the nuclear factor kappa-B signaling pathway, thereby normalizing the osteoporotic microenvironment. This collaborative therapeutic strategy that focuses on improving bone microenvironment and promoting osteogenesis provides new insight for the treatment of metabolic diseases such as osteoporosis.

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The combination of arginine and fluoride-containing bioactive glass acted synergistically in inhibiting enamel demineralization in permanent teeth

Qiu,

Liu,

Chen

2024

Journal of Dentistry

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Multifunctional magnesium organic framework-based photothermal and pH dual-responsive mouthguard for caries prevention and tooth self-healing promotion

Cited by 6 publications

References 39 publications

Dental Caries Management with Antibacterial Silver-Doped Prussian Blue Hydrogel by the Combined Effects of Photothermal Response and Ion Discharge

Dental Caries Management with Antibacterial Silver-Doped Prussian Blue Hydrogel by the Combined Effects of Photothermal Response and Ion Discharge

Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy

The combination of arginine and fluoride-containing bioactive glass acted synergistically in inhibiting enamel demineralization in permanent teeth

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