Multifunctional low temperature-cured PVA/PVP/citric acid-based hydrogel forming microarray patches: Physicochemical characteristics and hydrophilic drug interaction

Himawan, Achmad; Anjani, Qonita Kurnia; Detamornrat, Usanee; Vora, Lalitkumar K.; Permana, Andi Dian; Ghanma, Rand; Naser, Yara A.; Rahmawanty, Dina; Scott, Christopher J.; Donnelly, Ryan F.

doi:10.1016/j.eurpolymj.2023.111836

Cited by 12 publications

(6 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These peaks are assigned as the −CO ester group, C–C–O stretching, and O–C–C stretching, confirming the esterification between PVA and tartaric acid . Additionally, an absorption band at 1650 cm –1 in the FTIR spectra of F1 and F3 corresponds to the carbonyl group of PVP, illustrating the incorporation of PVA and PVP …”

Section: Resultsmentioning

confidence: 91%

“…This interaction facilitates the formation of both intermolecular and intramolecular cross-links between PVA and tartaric acid . The addition of PVP aims to provide a structural backbone for the hydrogel, thus improving the mechanical strength via hydrogen bonds with PVA. , A proposed reaction mechanism is available in Figure S1. Subsequently, heat treatment was also induced to the hydrogel to promote physical cross-linking.…”

Section: Resultsmentioning

confidence: 99%

“…HFMN also could exhibit a controlled release profile over a period of time by adjusting the hydrogel cross-linking density . The utilization of HFMN has been reported previously using various active compounds. − …”

Section: Introductionmentioning

confidence: 91%

“…Furthermore, the highest gel fraction values (>90%) were achieved by hydrogels heated at 140 °C for 2 h. Previous studies have confirmed that hydrogel formulations with loose cross-linking exhibit enhanced solute permeation, attributed to the unrestricted mobility of solutes within the hydrogel structure. 18,27 Considering this, hydrogels heated at 140 °C were found to be suboptimal for the HFMN formulation, as they exhibited a gel fraction percentage exceeding 85%.…”

Section: Preparation Of the Hydrogel And Swellingmentioning

confidence: 99%

“…70 Additionally, an absorption band at 1650 cm −1 in the FTIR spectra of F1 and F3 corresponds to the carbonyl group of PVP, illustrating the incorporation of PVA and PVP. 18 By comparing the FTIR spectra of F1 and F3 before and after heat treatment, it was clearly observed that same functional groups are still preserved, indicating that heat treatment did not alter the structure of HFMN. Notably, a decrease in intensity at ∼3350 cm −1 was observed postheat treatment in both F1 and F3, signifying a reduction in the −OH group intensity.…”

Section: Mechanical and Insertion Properties Of Hfmnmentioning

confidence: 99%

See 4 more Smart Citations

Application of Biomaterials in the Development of Hydrogel-Forming Microneedles Integrated with a Cyclodextrin Drug Reservoir for Improved Pharmacokinetic Profiles of Telmisartan

Enggi,

Sulistiawati,

Himawan

et al. 2024

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

However, its oral application is limited by its poor water solubility. This study presents the successful utilization of biomaterial-based hydrogelforming microneedles integrated with a direct compressed tablet reservoir (HFMN-DCT) for the transdermal delivery of telmisartan in the treatment of hypertension. The combination of PVP, PVA, and tartaric acid was used in the HFMN formulation. A range of cross-linking temperatures and times were employed to optimize the characteristics of the HFMN. The HFMN exhibited excellent swelling capacity, mechanical strength, and insertion properties. Additionally, the poorly soluble characteristic of TEL was improved by the inclusion complex formulation with β-cyclodextrin (βCD). Phase solubility analysis showed an A p -type diagram, indicating a higher-order complex between TEL and βCD, with respect to βCD. A ratio of TEL:βCD of 1:4 mM demonstrates the highest solubility enhancement of TEL. The inclusion complex formation was confirmed by FTIR, XRD, DSC, and molecular docking studies. A significantly higher release of TEL (up to 20-fold) from the inclusion complex was observed in the in vitro release study. Subsequently, a DCT reservoir was developed using various concentrations of sodium starch glycolate. Essentially, both the HFMN and DCT reservoir exhibit hemocompatibility and did not induce any skin irritation. The optimized combination of the HFMN-DCT reservoir showed an ex vivo permeation profile of 83.275 ± 2.405%. Notably, the proposed system showed superior pharmacokinetic profiles in the in vivo investigation using male Wistar rats. Overall, this study highlights the potential of HFMN-DCT reservoir systems as a versatile platform for transdermal drug delivery applications.

show abstract

Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Section: Preparation Of the Hydrogel And Swellingmentioning

confidence: 99%

Section: Mechanical and Insertion Properties Of Hfmnmentioning

confidence: 99%

See 3 more Smart Citations

Application of Biomaterials in the Development of Hydrogel-Forming Microneedles Integrated with a Cyclodextrin Drug Reservoir for Improved Pharmacokinetic Profiles of Telmisartan

Enggi,

Sulistiawati,

Himawan

et al. 2024

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

show abstract

Influence of the odd‐even effect of dicarboxylic acids as crosslinker on the physicochemical properties of polyvinyl alcohol

Gautam,

Warkar,

Jain

2024

J of Applied Polymer Sci

View full text Add to dashboard Cite

Polyvinyl alcohol (PVA) was crosslinked with a homologous series of four different dicarboxylic acids, HOOC(CH2) n‐2COOH (n = 2 to 5) viz. oxalic acid (OA; C2), malonic acid (MA; C3), succinic acid (SA; C4) and glutaric acid (GA; C5) containing odd and even number of carbon atoms. The characterization and assessment of synthesized crosslinked films were done using ATR‐FTIR, XRD, SEM, AFM, DSC, rheology, percent swelling and sessile drop contact angle. The odd‐even effect of dicarboxylic acids was observed to significantly influence the physicochemical properties of PVA when employed as a crosslinker. PVA films crosslinked using dicarboxylic acids containing an even number of carbon atoms, displayed translucency, roughness, and an irregular matrix. In contrast, films incorporating an odd number of carbon atoms were transparent, homogenous, and densely packed. Furthermore, films containing even acids exhibited relatively lower crystallinity, lower melting temperature (Tm) and displayed an unexpected irregular trend in swelling as crosslinker concentration increased compared to films containing dicarboxylic acids with an odd number of carbon atoms which exhibits a consistent swelling with increasing crosslinker concentration. These results are attributed to the difference in the solubility and crystal structures of the odd‐even series of dicarboxylic acids.

show abstract

Conductive hydrogel as stress‐strain sensor for human motion monitoring

Mondal,

Sofiuzzaman,

Ahmed

et al. 2024

Nano Select

View full text Add to dashboard Cite

Hydrogel‐based stress‐strain sensors have attracted immense attention recently for developing wearable electronic devices and health‐monitoring systems owing to their intrinsic soft characteristics and flexible nature. Developing hydrogel that has high conductivity, better mechanical performance, and elasticity is necessary for better analysis or getting accurate measurement data. Hence, this study focuses on the development of novel conductive hydrogels with enhanced mechanical, swelling, and sensing properties targeting the advancement of stress‐strain sensitive hydrogel sensors. Polyvinyl alcohol (PVA) and citric acid (CA) have been used to prepare esterified PVA/CA hydrogels while using a simple one‐pot method followed by doping with a conductive polymer (polyaniline, PANI). The resultant PVA/CA/PANI hydrogel displayed a high water uptake capacity of ∼4200%, a high mechanical strain of 700%, high puncture resistance, large durability, and a fast response time when applied as soft human‐motion sensors in real‐time measurement of large‐scale and subtle human physiological stress activities (i.e., joint motions in the forefinger, elbow, wrist, and neck). The high strain sensitivity and ultrahigh stretchability of hydrogel sensors allow them to detect small mechanical changes caused by human movement showing their great potential for hydrogel‐based sensor device fabrication.

show abstract

Multifunctional low temperature-cured PVA/PVP/citric acid-based hydrogel forming microarray patches: Physicochemical characteristics and hydrophilic drug interaction

Cited by 12 publications

References 52 publications

Application of Biomaterials in the Development of Hydrogel-Forming Microneedles Integrated with a Cyclodextrin Drug Reservoir for Improved Pharmacokinetic Profiles of Telmisartan

Application of Biomaterials in the Development of Hydrogel-Forming Microneedles Integrated with a Cyclodextrin Drug Reservoir for Improved Pharmacokinetic Profiles of Telmisartan

Influence of the odd‐even effect of dicarboxylic acids as crosslinker on the physicochemical properties of polyvinyl alcohol

Conductive hydrogel as stress‐strain sensor for human motion monitoring

Contact Info

Product

Resources

About