Multifunctional light-activatable nanocomplex conducting temperate-heat photothermal therapy to avert excessive inflammation and trigger augmented immunotherapy

Li, Lü; Liang, Xiuqi; He, Tong‐Chuan; Li, Xinchao; Huang, Xiaojian; Wang, Ning; Shen, Mei-Lin; Shu, Yaqian; Wu, Rui; Zhang, Miaomiao; Wu, Qinjie; Gong, Changyang

doi:10.1016/j.biomaterials.2022.121815

Cited by 22 publications

(13 citation statements)

References 40 publications

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“…The results indicated that HHPI@GA NPs exhibited the most pronounced cytotoxicity under 808 nm laser irradiation. The difference between the HHHI@GA + L and HHPI@GA + L groups was attributed to the enhanced PDT effect of PFC, whereas the difference between the HHPI + L and HHPI@GA + L groups was attributed to the enhanced PTT effect caused by GA (which inhibited the expression of HSP90) [ 51 ]. The cytotoxicity test showed that enhanced PTT and PDT strategy effectively improved the lethality toward cancer cells.…”

Section: Resultsmentioning

confidence: 99%

A pH-responsive nanoplatform with dual-modality imaging for enhanced cancer phototherapy and diagnosis of lung metastasis

Yuan,

Han,

et al. 2024

J Nanobiotechnol

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To address the limitations of traditional photothermal therapy (PTT)/ photodynamic therapy (PDT) and real-time cancer metastasis detection, a pH-responsive nanoplatform (NP) with dual-modality imaging capability was rationally designed. Herein, 1 H,1 H-undecafluorohexylamine (PFC), served as both an oxygen carrier and a 19F magnetic resonance imaging (MRI) probe, and photosensitizer indocyanine green (ICG) were grafted onto the pH-responsive peptide hexahistidine (H6) to form H6-PFC-ICG (HPI). Subsequently, the heat shock protein 90 inhibitor, gambogic acid (GA), was incorporated into hyaluronic acid (HA) modified HPI (HHPI), yielding the ultimate HHPI@GA NPs. Upon self-assembly, HHPI@GA NPs passively accumulated in tumor tissues, facilitating oxygen release and HA-mediated cell uptake. Once phagocytosed by lysosomes, protonation of H6 was triggered due to the low pH, resulting in the release of GA. With near-infrared laser irradiation, GA-mediated decreased HSP90 expression and PFC-mediated increased ROS generation amplified the PTT/PDT effect of HHPI@GA, leading to excellent in vitro and in vivo anticancer efficacies. Additionally, the fluorescence and 19F MRI dual-imaging capabilities of HHPI@GA NPs enabled effective real-time primary cancer and lung metastasis monitoring. This work offers a novel approach for enhanced cancer phototherapy, as well as precise cancer diagnosis.

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Section: Resultsmentioning

confidence: 99%

A pH-responsive nanoplatform with dual-modality imaging for enhanced cancer phototherapy and diagnosis of lung metastasis

Yuan,

Han,

et al. 2024

J Nanobiotechnol

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“…1062,1063 A common type of triple combination therapy includes chemotherapy, phototherapy, and immunotherapy, in which both phototherapy and chemotherapy promote immune responses activating T cells in the immune microenvironment for suppressing the growth of tumors, including recurrent and metastatic tumors. [1064][1065][1066][1067] Sun et al 1068 developed a novel polypyrrole NP for breast tumor-targeted chemotherapy, immunotherapy, and photothermal. An efficient tumor-targeting multifunctional NP PPy@CPT-HA-IRDye800CW (P@CH) was created by using the NIR dye IRDye800CW conjugated with CPT conjugated HA shells.…”

Section: Nps For Integrative Therapymentioning

confidence: 99%

“…Apart from the integration of two treatment strategies mentioned above, integration of three or more treatment strategies is becoming the norm 1062,1063 . A common type of triple combination therapy includes chemotherapy, phototherapy, and immunotherapy, in which both phototherapy and chemotherapy promote immune responses activating T cells in the immune microenvironment for suppressing the growth of tumors, including recurrent and metastatic tumors 1064–1067 . Sun et al 1068 developed a novel polypyrrole NP for breast tumor‐targeted chemotherapy, immunotherapy, and photothermal.…”

Section: Cancer Therapies Using Npsmentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed to overcome different challenges and to achieve sophisticated delivery routes for enhancement of a series of therapies. Inspiring advances have been achieved in the field of cancer therapy using NPs. In this review, we aim to summarize the up‐to‐date progression of NPs for addressing various challenges, and expect to elicit novel and potential opportunities alternatively. We first introduce different sorts of NP technologies, illustrate their mechanisms, and present their applications. Then, the achievements made by NPs to break obstacles in delivering cargoes to specific sites through particular routes are highlighted, including long‐circulation, tumor targeting, responsive release, and subcellular localization. We subsequently retrospect recent research of NPs in different cancer treatments from single therapy, like chemotherapy, to combination therapy, like chemoradiotherapy, and to integrative therapy. Finally, the challenges and perspectives of NPs in cancer therapy, and their potential impact on the field of oncology are discussed. We believe this review can offer a deeper understanding of the challenges and opportunities of NPs for cancer therapy.

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“…Li et al presented a multifunctional light-activable nanocomplex (MILAN), which was designed for moderate-heat photothermal therapy (PTT) to induce apoptosis without inducing necrosis. 112 This approach helped prevent excessive inflammation in tumors and enhanced cancer immunotherapy against triple-negative breast cancer. This nanocomplex was composed of temperature-sensitive liposomes as carriers, loading indocyanine green (ICG) and glycyrrhetinic acid (GA) in the liposome cavity and phospholipid bilayers, respectively, through lipid film hydration.…”

Section: Nir-responsive Nanomaterialsmentioning

confidence: 99%